Nature Communications

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27.01.2022

Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Authors Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C Journal Nature Communications Citation Nat Commun. 2022 Jan 27;13(1):545. Abstract Proton-translocating respiratory complexes assemble into supercomplexes that are proposed to increase the efficiency of energy
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11.01.2022

The RNA methyltransferase METTL8 installs m3C32 modifications in mitochondrial tRNAThr/Ser(UCN) to optimise tRNA structure and translation

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial
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08.12.2021

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Authors Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO Journal Nature Communications Citation Nat Commun. 2021 Dec 8;12(1):7129. Abstract The brain extracellular matrix (ECM) consists of
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11.11.2021

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Authors Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer
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29.09.2021

Mapping protein interactions in the active TOM-TIM23 supercomplex

Authors Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz C, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Urlaub H, Rehling P Journal Nature Communications Citation Nat Commun 12, 5715 (2021) Abstract Nuclear-encoded mitochondrial proteins destined for the matrix have to be transported
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23.07.2021

Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

Authors Cretu C, Gee P, Liu X, Agrawal A, Nguyen TV, Ghosh AK, Cook A, Jurica M, Larsen NA, Pena V Journal Nature Communications Citation Nat Commun. 2021 Jul 23;12(1):4491. Abstract Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection
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22.07.2021

Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

Authors Beckert B, Leroy EC, Sothiselvam S, Bock LV, Svetlov MS, Graf M, Arenz S, Abdelshahid M, Seip B, Grubmüller H, Mankin AS, Innis CA, Vázquez-Laslop N, Wilson DN Journal Nature Communications Citation Nat Commun 12, 4466 (2021). Abstract Macrolides and ketolides comprise a family of clinically important antibiotics that
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13.07.2021

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Authors Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C Journal Nature Communications
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16.06.2021

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

Authors Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2021 Jun 16;12(1):3672. Abstract Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC)
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28.05.2021

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

Authors Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P Journal Nature Communications Citation Nat Commun. 2021 May 28;12(1):3232. Abstract Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like
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