Nature Communications

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13.07.2021

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Authors Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C Journal Nature Communications
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16.06.2021

Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling

Authors Hillen HS, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2021 Jun 16;12(1):3672. Abstract Ribosome biogenesis requires auxiliary factors to promote folding and assembly of ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC)
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28.05.2021

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing

Authors Oberbeckmann E, Niebauer V, Watanabe S, Farnung L, Moldt M, Schmid A, Cramer P, Peterson CL, Eustermann S, Hopfner KP, Korber P Journal Nature Communications Citation Nat Commun. 2021 May 28;12(1):3232. Abstract Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like
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21.05.2021

Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology

Authors Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E,
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14.04.2021

In situ architecture of neuronal α-Synuclein inclusions

Authors Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R Journal Nature Communications Citation Nat Commun 12, 2110 (2021). Abstract The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were
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16.02.2021

Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

Authors Zhang Y, Dijkman PM, Zou R, Zandl-Lang M, Sanchez RM, Eckhardt-Strelau L, Köfeler H, Vogel H, Yuan S, Kudryashev M Journal Nature Communications Citation Nat Commun. 2021 Feb 16;12(1):1074. Abstract Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the
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05.02.2021

Two mechanisms drive pronuclear migration in mouse zygotes

Authors Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M Journal Nature Communications Citation Nat Commun 12, 841 (2021). Abstract A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei
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04.02.2021

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

Authors Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S. Journal Nature Communications Citation Nat Commun. 2021 Feb 4;12(1):782. Abstract The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins,
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12.01.2021

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

Authors Kokic G, Hillen HS, Tegunov D, Dienemann C, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P Journal Nature Communications Citation Nat Commun. 2021 Jan 12;12(1):279. Abstract Remdesivir is the only FDA-approved drug for the treatment of COVID-19 patients. The active form of remdesivir acts as
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30.10.2020

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity.

Authors Ruhlandt D, Andresen M, Jensen N, Gregor I, Jakobs S, Enderlein J, Chizhik AI Journal Communications Biology Citation Commun Biol. 2020 Oct 30;3(1):627. Abstract One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore
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