Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Posted on 12. November 2020

Authors

Dankovich TM, Kaushik R, Cassinelli Petersen G, Giro PE, Abdul Hadi H, Bao G, Beuermann S, Cooper BH, Dityatev A, Rizzoli SO

Journal

bioRxiv

Citation

bioRxiv 2020.11.11.377515.

Abstract

The brain extracellular matrix (ECM) assembles around neurons and synapses, and is thought to change only rarely, through proteolysis and renewed protein synthesis. We report here an alternative ECM remodeling mechanism, based on the recycling of ECM molecules. We found that a key ECM protein, Tenascin-R, is frequently endocytosed, and later resurfaces, preferentially near synapses. The TNR molecules complete this cycle within ∼3 days, in an activity-dependent fashion.