Events

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Epigenetic Regulation of Gene Transcritpion”

07 Sept: “Epigenetic processes in heart & brain diseases”, Prof. Dr. André Fischer, Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)

21 Sept: “Towards therapies against SARS-CoV2 infections”, Prof. Dr. Matthias Dobbelstein, Institute of Molecular Oncology, UMG

05 Oct: “tba”, Prof. Dr. Elisabeth Zeisberg, Department of Cardioloy and Pneumology, UMG

02 Nov: “tba”, Prof. Dr. Silvio Rizzoli, Institute of Neuro- and Sensory Physiology, UMG

16 Nov: “tba”, Prof. Dr. Ralf Ficner, Department of Molecular Structural Biology, Institute for Microbiology & Genetics, UG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

Professor Tom Kirchhausen from the Department of Cell Biology, Harvard Medical School, Boston will talk about “Mitotic formation of nuclear pore complexes”.

Abstract

Frontier optical-imaging modalities exemplified by the lattice light-sheet microscope invented by Eric Betzig sets new visualization standards for analyzing and understanding sub-cellular processes in the complex and dynamic three-dimensional environment of living-cells in isolation and within tissues of an organism. By using ultra-thin sheets of light to rapidly illuminate biological samples with extremely low photon doses, 3D experiments previously limited to seconds or minutes by photo-bleaching or by photo-toxicity, can now be done at diffraction limited resolution and high-temporal precision with unprecedented duration of minutes or hours. We believe this ability to image with minimal perturbations is ideally suited to support hypothesis-generating research geared towards new discoveries. The talk will illustrate how use of lattice light-sheet microscopy allowed us to uncover a templating process mediating the formation of nuclear pores during mitosis. We ‘saw’ incomplete mitotic dissociation of all NPCs in dividing cells yielding reusable building blocks consisting of octameric inner and outer ring nuclear subassemblies; the building blocks remained associated with fenestrated mitotic ER sheets and through telophase templated post-mitotic NPCs assembly during the attachment of the fenestrated ER sheets to decondensed chromatin. Because these building blocks are ‘immortal’ and survive many cycles of cell division, they were able to template assembly of many post-mitotic NPC during subsequent cell cycles.

Host: Tiago F. Outeiro

Poster of the talk

Chairs: Tobias Moser and Thomas Mager

Professor Simon Wiegert from the Center for Molecular Neurobiology Hamburg (ZMNH), Germany will talk about “Illuminating hippocampal circuits: tools, synapses and networks”

Abstract

How do the networks of the brain encode and store information? Nodes in brain networks can change their connectivity upon learning. Such changes in connectivity are believed to alter the flow of information within and between brain regions. However, in order to understand such macroscopic changes, we still need to better understand the underlying mechanisms at the microscopic scale. This is challenging, since the brain operates at different levels of complexity, which are spanning orders of magnitude in space and time. Therefore, we need to expand our experimental toolsets to facilitate the investigation of brain networks at multiple scales. In my presentation I will argue that optical methods enable us to get closer to this goal. In the first part of my presentation, I will briefly talk about a potential synaptic mechanism underlying changes in connectivity in the hippocampus. I will then present a study that investigates how different anesthetics uniquely alter synaptic stability, hippocampal network dynamics and memory formation in mice. In the last part of my talk, I will present new optogenetic tools from my lab that enable addressing hitherto inaccessible questions in the field of neuroscience.

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Epigenetic Regulation of Gene Transcritpion”

07 Sept: “Epigenetic processes in heart & brain diseases”, Prof. Dr. André Fischer, Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)

21 Sept: “Towards therapies against SARS-CoV2 infections”, Prof. Dr. Matthias Dobbelstein, Institute of Molecular Oncology, UMG

05 Oct: “Epigentic processes as therapeutic targets in organ fibrosis”, Prof. Dr. Elisabeth Zeisberg, Department of Cardioloy and Pneumology, UMG

02 Nov: “tba”, Prof. Dr. Silvio Rizzoli, Institute of Neuro- and Sensory Physiology, UMG

16 Nov: “tba”, Prof. Dr. Ralf Ficner, Department of Molecular Structural Biology, Institute for Microbiology & Genetics, UG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Organized Protein Assemblies”

30 Nov 2021: “tba”, Prof. Dr. Tiago Outeiro, Department of Experimental Neurodegeneration, UMG

11 Jan 2022: “tba”, Prof. Dr. Mathias Bähr, Department of Neurology, UMG

25 Jan 2022: “tba”, Prof. Dr. Christine Stadelmann-Nessler, Institute of Neuropathology, UMG

08 Febr 2022: “tba”, Dr. Melina Schuh, Department of Meiosis, MPI for Biophysical Chemistry

22 Febr 2022: “tba”, Prof. Dr. Timo Betz, Third Institute of Physics – Biophysics, UG

08 March 2022: “tba”, Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology, UMG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Organized Protein Assemblies”

30 Nov 2021: “tba”, Prof. Dr. Tiago Outeiro, Department of Experimental Neurodegeneration, UMG

11 Jan 2022: “tba”, Prof. Dr. Mathias Bähr, Department of Neurology, UMG

25 Jan 2022: “tba”, Prof. Dr. Christine Stadelmann-Nessler, Institute of Neuropathology, UMG

08 Febr 2022: “tba”, Dr. Melina Schuh, Department of Meiosis, MPI for Biophysical Chemistry

22 Febr 2022: “tba”, Prof. Dr. Timo Betz, Third Institute of Physics – Biophysics, UG

08 March 2022: “tba”, Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology, UMG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Organized Protein Assemblies”

30 Nov 2021: “tba”, Prof. Dr. Tiago Outeiro, Department of Experimental Neurodegeneration, UMG

11 Jan 2022: “tba”, Prof. Dr. Mathias Bähr, Department of Neurology, UMG

25 Jan 2022: “tba”, Prof. Dr. Christine Stadelmann-Nessler, Institute of Neuropathology, UMG

08 Febr 2022: “tba”, Dr. Melina Schuh, Department of Meiosis, MPI for Biophysical Chemistry

22 Febr 2022: “tba”, Prof. Dr. Timo Betz, Third Institute of Physics – Biophysics, UG

08 March 2022: “tba”, Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology, UMG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Organized Protein Assemblies”

30 Nov 2021: “tba”, Prof. Dr. Tiago Outeiro, Department of Experimental Neurodegeneration, UMG

11 Jan 2022: “tba”, Prof. Dr. Mathias Bähr, Department of Neurology, UMG

25 Jan 2022: “tba”, Prof. Dr. Christine Stadelmann-Nessler, Institute of Neuropathology, UMG

08 Febr 2022: “tba”, Dr. Melina Schuh, Department of Meiosis, MPI for Biophysical Chemistry

22 Febr 2022: “tba”, Prof. Dr. Timo Betz, Third Institute of Physics – Biophysics, UG

08 March 2022: “tba”, Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology, UMG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Organized Protein Assemblies”

30 Nov 2021: “tba”, Prof. Dr. Tiago Outeiro, Department of Experimental Neurodegeneration, UMG

11 Jan 2022: “tba”, Prof. Dr. Mathias Bähr, Department of Neurology, UMG

25 Jan 2022: “tba”, Prof. Dr. Christine Stadelmann-Nessler, Institute of Neuropathology, UMG

08 Febr 2022: “tba”, Dr. Melina Schuh, Department of Meiosis, MPI for Biophysical Chemistry

22 Febr 2022: “tba”, Prof. Dr. Timo Betz, Third Institute of Physics – Biophysics, UG

08 March 2022: “tba”, Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology, UMG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh

The Hertha Sponer College Lecture Series is addressed to interested students, PhD candidates, postdocs, and PIs. The overall idea is to fundamentally explain research by providing an overview about the general aims of the six MBExC Research Alliances with special focus on the specific techniques that are developed and applied. The lectures take place on Tuesdays at 5 pm within the semester term, and are offered by MBExC PIs. Subsequent to lecture and discussion, Hertha Sponer College members have the opportunity to “Meet-the-PI” and each other for asking more specific or general questions, networking and socializing.

Session:  “Organized Protein Assemblies”

30 Nov 2021: “tba”, Prof. Dr. Tiago Outeiro, Department of Experimental Neurodegeneration, UMG

11 Jan 2022: “tba”, Prof. Dr. Mathias Bähr, Department of Neurology, UMG

25 Jan 2022: “tba”, Prof. Dr. Christine Stadelmann-Nessler, Institute of Neuropathology, UMG

08 Febr 2022: “tba”, Dr. Melina Schuh, Department of Meiosis, MPI for Biophysical Chemistry

22 Febr 2022: “tba”, Prof. Dr. Timo Betz, Third Institute of Physics – Biophysics, UG

08 March 2022: “tba”, Prof. Dr. Niels Voigt, Institute of Pharmacology and Toxicology, UMG

For log-in information please contact: ed.negnitteog-inu.dem@darnoc.ekieh