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29.09.2023

Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase

Authors Egbert JR, Silbern I, Uliasz TF, Lowther KM, Yee SP, Urlaub H, Jaffe LA Journal Biology of Reproduction Citation Biol Reprod. 2023 Sep 29:ioad130. Abstract In response to luteinizing hormone, multiple proteins in rat and mouse granulosa cells are rapidly dephosphorylated, but the responsible phosphatases remain to be identified.
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25.09.2023

Imaging of excised cochleae by micro-CT: staining, liquid embedding, and image modalities

Authors Schaeper JJ, Liberman MC, Salditt T Journal Journal of Medical Imaging Citation J. Med. Imag. 10(5) 053501 (25 September 2023) Abstract Purpose: Assessing the complex three-dimensional (3D) structure of the cochlea is crucial to understanding the fundamental aspects of signal transduction in the inner ear and is a prerequisite
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22.09.2023

Devising a framework of optogenetic coding in the auditory pathway: insights from auditory midbrain recordings

Authors Micheal M, Wolf BJ, Klinge-Strahl A, Jeschke M, Moser T, Dieter A Journal Brain Stimulation Citation Brain Stimul. 2023 Sep 29:S1935-861X(23)01920-4. Abstract Cochlear implants (CIs) restore activity in the deafened auditory system via electrical stimulation of the auditory nerve. As the spread of electric current in biological tissues is
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13.09.2023

Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis?

Authors Thümmler K, Wrzos C, Franz J, McElroy D, Cole JJ, Hayden L, Arseni D, Schwarz F, Junker A, Edgar JM, Kügler S, Neef A, Wolf F, Stadelmann C, Linington C. Journal Neuropathology and Applied Neurobiology Citation Neuropathol Appl Neurobiol. 2023 Sep 13:e12935. Abstract Aims: Fibroblast growth factor (FGF) signalling
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13.09.2023

Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression

Authors Kaurani L, Besse M, Methfessel I, Methi A, Zhou J, Pradhan R, Burkhardt S, Kranaster L, Sartorius A, Habel U, Grözinger M, Fischer A, Wiltfang J, Zilles-Wegner D Journal Translational Psychiatry Citation Transl Psychiatry. 2023 Sep 13;13(1):294. Abstract There is a strong medical need to develop suitable biomarkers to
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11.09.2023

Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis

Authors Kanwischer L, Xu X, Saifuddin AB, Maamari S, Tan X, Alnour F, Tampe B, Meyer T, Zeisberg M, Hasenfuss G, Puls M, Zeisberg EM Journal Clinical Epigenetics Citation Clin Epigenetics. 2023 Sep 11;15(1):149. Abstract Background: Aortic stenosis (AS) is one of the most common cardiac diseases and major cause
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07.09.2023

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development

Authors Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A, Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Díaz I Pedrosa N, Rapedius M, Döring Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Brügmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann
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06.09.2023

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses

Authors Karagulyan N, Moser T Journal Frontiers in Molecular Neuroscience – Molecular Signalling and Pathways Citation Front Mol Neurosci. 2023 Sep 6;16:1248941. Abstract Neural sound encoding in the mammalian cochlea faces the challenge of representing audible sound pressures that vary over six orders of magnitude. The cochlea meets this demand
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05.09.2023

Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

Authors Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB Journal Nature Communications Citation Nat Commun. 2023 Sep 5;14(1):5395. Abstract The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility and fertilization via HCO3−-stimulated cAMP synthesis. A complex
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30.08.2023

N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody

Authors Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein A, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M Journal iScience Citation iScience. 2023 Aug 30;26(10):107786. Abstract N4-hydroxycytidine (NHC), the active compound of the drug Molnupiravir, is incorporated into SARS-CoV-2 RNA, causing
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