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Impact Factor


April 2024
Cardiovascular Research
Liutkute A, Prosser BL, Voigt N
April 2024
BioRxiv
Fenech EJ, Kupervaser M, Boshnakovska A, Ravid S, Gomes Castro I, Asraf Y, Callegari S, Lenz C, Rehling P, Schuldiner M
April 2024
Cell Death & Disease
Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA
April 2024
BioRxiv
Meissner-Bernard C, Jenkins B, Rupprecht P, Arn Bouldoires E, Zenke F, Friedrich RW, Frank T
April 2024
Nature Communications
Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K
April 2024
Annual Review of Biochemistry
Höbartner C, Bohnsack KE, Bohnsack MT
April 2024
Annual Review of Neurosciences
Huet A, Mager T, Goßler C, Moser T

Authors

Huet A, Mager T, Goßler C, Moser T

Journal

Annual Review of Neurosciences

Citation

Annu Rev Neurosci. 2024 Apr 9.

Abstract

The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical stimulation of the auditory nerve, the broad spread of current from each electrode acts as a bottleneck that limits the transfer of sound frequency information. Hence, there remains a major unmet medical need for improving the quality of hearing with CIs. Recently, optogenetic stimulation of the cochlea has been suggested as an alternative approach for hearing restoration. Cochlear optogenetics promises to transfer more sound frequency information, hence improving hearing, as light can conveniently be confined in space to activate the auditory nerve within smaller tonotopic ranges. In this review, we discuss the latest experimental and technological developments of optogenetic hearing restoration and outline remaining challenges en route to clinical translation.

DOI

10.1146/annurev-neuro-070623-103247
 
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