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September 2023
Neuropathology and Applied Neurobiology
Fibroblast growth factor 9 (FGF9) mediated neurodegeneration: implications for progressive multiple sclerosis?
Thümmler K, Wrzos C, Franz J, McElroy D, Cole JJ, Hayden L, Arseni D, Schwarz F, Junker A, Edgar JM, Kügler S, Neef A, Wolf F, Stadelmann C, Linington C.
September 2023
Translational Psychiatry
Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression
Kaurani L, Besse M, Methfessel I, Methi A, Zhou J, Pradhan R, Burkhardt S, Kranaster L, Sartorius A, Habel U, Grözinger M, Fischer A, Wiltfang J, Zilles-Wegner D
September 2023
Cardiovascular Research
Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development
Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A, Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Díaz I Pedrosa N, Rapedius M, Döring Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Brügmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann WH, Voigt N.
September 2023
Frontiers in Molecular Neuroscience - Molecular Signalling and Pathways
Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses
Karagulyan N, Moser T
August 2023
iscience
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein A, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M
August 2023
International Journal of Molecular Sciences
Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease
Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A
August 2023
BioRxiv
Unravelling ATP processing by the AAA+ protein p97 at the atomic level
Shein M, Hitzenberger M, Cheng T, Rout S, Leitl K, Sato Y, Zacharias M, Sakata E, Schuetz A
August 2023
iScience
En route to sound coding strategy for optical cochlear implants
Khurana L, Harczos T, Moser T, Jablonski L
August 2023
BioRxiv
Doubling the resolution of single-molecule localization microscopy with image scanning microscopy
Radmacher N, Nevskyi O, Gallea JI, Thiele JC, Gregor I, Rizzoli SO, Enderlein J
August 2023
BioRxiv
Segment Anything for Microscopy
Archit A, Nair S, Khalid N, Hilt P, Rajashekar V, Freitag M, Gupta S, Dengel A, Ahmed S, Pape C

Authors

Archit A, Nair S, Khalid N, Hilt P, Rajashekar V, Freitag M, Gupta S, Dengel A, Ahmed S, Pape C

Journal

BioRxiv

Citation

bioRxiv 2023.08.21.554208.

Abstract

We present Segment Anything for Microscopy, a tool for interactive and automatic segmentation and tracking of objects in multi-dimensional microscopy data. Our method is based on Segment Anything, a vision foundation model for image segmentation. We extend it by training specialized models for microscopy data that significantly improve segmentation quality for a wide range of imaging conditions. We also implement annotation tools for interactive (volumetric) segmentation and tracking, that speed up data annotation significantly compared to established tools. Our work constitutes the first application of vision foundation models to microscopy, laying the groundwork for solving image analysis problems in these domains with a small set of powerful deep learning architectures.

DOI

10.1101/2023.08.21.554208
 

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