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June 2022
Computational and Structural Biotechnology Journal
Khurana L, Keppeler D, Jablonski L, Moser T
June 2022
Science Reports
Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE
June 2022
Neurobiology of Disease
Domingues R, Sant'Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF
June 2022
Science Advances
Thiele JC, Jungblut M, Helmerich DA, Tsukanov R, Chizhik A, Chizhik AI, Schnermann MJ, Sauer M, Nevskyi O, Enderlein J
June 2022
Science Advances
Grabner CP, Jansen I, Neef J, Weihs T, Schmidt R, Riedel D, Wurm CA, Moser T
May 2022
PNAS
Elizarova S, Chouaib A, Shaib A, Hill B, Mann F, Brose N, Kruss S, Daniel JA
May 2022
Science
Zimmermann WH
May 2022
Biophysical Journal
Yudovich S, Marzouqe A, Kantorovitsch J, Teblum E, Chen T, Enderlein J, Miller EW, Weiss S
May 2022
Journal of the American Chemical Society
Garrido-Charles A, Huet AT, Matera C, Thirumalai A, Hernando J, Llebaria A, Moser T, Gorostiza P

Authors

Garrido-Charles A, Huet AT, Matera C, Thirumalai A, Hernando J, Llebaria A, Moser T, Gorostiza P

Journal

Journal of the American Chemical Society

Citation

J Am Chem Soc. 2022 May 18.

Abstract

Artificial control of neuronal activity enables studies of neural circuits and restoration of neural function. Direct, rapid, and sustained photocontrol of intact neurons could overcome the limitations of established electrical stimulation such as poor selectivity. We have developed fast photoswitchable ligands of glutamate receptors to enable neuronal control in the auditory system. The new photoswitchable ligands induced photocurrents in untransfected neurons upon covalently tethering to endogenous glutamate receptors and activating them reversibly with visible light pulses of few milliseconds. As a proof of concept of these molecular prostheses, we apply them to the ultrafast synapses of auditory neurons of the cochlea that encode sound and provide auditory input to the brain. This drug-based method affords stimulation of auditory neurons of adult gerbils at hundreds of hertz without genetic manipulation that would be required for their optogenetic control. This indicates that the new photoswitchable ligands are also applicable to the spatiotemporally control of fast spiking interneurons in the brain.

DOI

10.1021/jacs.1c12314
 
Pubmed Link

 

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