Publications

Home >> Research >> Publications
Impact Factor

October 2021
Nature Physics
Intracellular softening and increased viscoelastic fluidity during division
Hurst S, Vos BE, Brandt M, Betz T
October 2021
Cell
An in vitro system to silence mitochondrial gene expression
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
October 2021
EMBO Molecular Medicine
A microRNA signature that correlates with cognition and is a target against cognitive decline
Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Metzger CD, Munk MH, Perneczky R, Peters O, Priller J, Rauchmann BS, Roy N, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Wagner M, Wiltfang J, Düzel E, Jessen F; Delcode Study Group, Rizzoli SO, Zimmermann WH, Schulze TG, Falkai P, Sananbenesi F, Fischer A
October 2021
arXiv
Optimal transfer functions for bandwidth-limited imaging
Stallinga S, Delon A, Enderlein J
October 2021
Translational Psychiatry
Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501
Goldberg M, Islam MR, Kerimoglu C, Lancelin C, Gisa V, Burkhardt S, Krüger DM, Marquardt T, Malchow B, Schmitt A, Falkai P, Sananbenesi F, Fischer A
October 2021
Trends in Cell Biology
Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis
Lavdovskaia E, Hillen HS, Richter-Dennerlein R
September 2021
Nature Communications
Mapping protein interactions in the active TOM-TIM23 supercomplex
Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz Ch, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Henning Urlaub H, Rehling P
September 2021
Studies in Health Technology and Informatics
Management of Metadata Types in Basic Cardiological Research
Kusch H, Kossen R, Suhr M, Freckmann L, Weber L, Henke C, Lehmann C, Rheinländer S, Aschenbrandt G, Kühlborn LK, Marzec B, Menzel J, Schwappach B, Zelarayán LC, Cyganek L, Antonios G, Kohl T, Lehnart SE, Zoremba M, Sax U, Nussbeck SY
September 2021
Science Advances
H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion
Kerimoglu C, Pham L, Tonchev AB, Sakib MS, Xie Y, Sokpor G, Ulmke PA, Kaurani L, Abbas E, Nguyen H, Rosenbusch J, Michurina A, Capece V, Angelova M, Maricic N, Brand-Saberi B, Esgleas M, Albert M, Minkov R, Kovachev E, Teichmann U, Seong RH, Huttner WB, Nguyen HP, Stoykova A, Staiger JF, Fischer A, Tuoc T
September 2021
Nucleic Acids Research
Structure of an inactive RNA polymerase II dimer
Aibara S, Dienemann Ch, Cramer P

Authors

Aibara S, Dienemann Ch, Cramer P

Journal

Nucleic Acids Research

Citation

Nucleic Acids Research, 2021; Sep 16, gkab783

Abstract

Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it is unclear whether and how the two other RNA polymerases dimerize. Here we present the cryo-electron microscopy (cryo-EM) structure of a mammalian Pol II dimer at 3.5 Å resolution. The structure differs from the Pol I dimer and reveals that one Pol II copy uses its RPB4-RPB7 stalk to penetrate the active centre cleft of the other copy, and vice versa, giving rise to a molecular handshake. The polymerase clamp domain is displaced and mobile, and the RPB7 oligonucleotide-binding fold mimics the DNA–RNA hybrid that occupies the cleft during active transcription. The Pol II dimer is incompatible with nucleic acid binding as required for transcription and may represent an inactive storage form of the polymerase.

DOI

10.1093/nar/gkab783

Pubmed Link

  • Recent Tweets

    • X
    X