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Latest Publications


December 2020
Cell Reports
Jablonski L, Harczos T, Wolf B, Hoch G, Dieter A, Hessler R, Ayub S, Ruther P, Moser T
November 2020
Nature Protocols
Qin S, Isbaner S, Gregor I, Enderlein J
November 2020
bioRxiv
Medina L, Gonzalez Lizarraga F, Dominguez Meijide A, Ploper D, Parrales V, Sequeira S, Sol Cima Omorri M, Zweckstetter M, del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehin RN, Socias SB
November 2020
Science Reports
Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanovic D, Rizzoli S, Köster S
November 2020
Brain Science
Dominguez-Meijide A, Vasili E, Outeiro TF
November 2020
Algorithms
del Alamo M, Li H, Munk A, Werner F
November 2020
Magnetic Resonance in Medicine
Maier O, Baete SH, Fyrdahl A, Hammernik K, Harrevelt S, Kasper L, Karakuzu A, Loecher M, Patzig F, Tian Y, Wang K, Gallichan D, Uecker M, Knoll F
November 2020
bioRxiv
Dankovich TM, Kaushik R, Cassinelli Petersen G, Giro PE, Abdul Hadi H, Bao G, Beuermann S, Cooper BH, Dityatev A, Rizzoli SO
November 2020
bioRxiv
Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF

Authors

Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF

Journal

BioRxiv

Citation

bioRxiv 2020.11.06.371229.

Abstract

Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially proposed to be due to its anti-inflammatory properties. More recently, an additional mechanism by which doxycycline may exert its neuroprotective effects has been proposed as it has been shown that it inhibits amyloid aggregation. Here, we studied the effects of doxycycline on aSyn aggregation in vivo, in vitro and in a cell free system using real-time quaking induced conversion (RT-QuiC). Our results show that doxycycline decreases the number and size of aSyn aggregates in cells. In addition, doxycycline inhibits the aggregation and seeding of recombinant aSyn, and attenuates the production of mitochondrial-derived reactive oxygen species. Finally, we found doxycycline induces a cellular redistribution of the aggregates in an animal model of PD that is associated with a recovery of dopaminergic function. In summary, we provide strong evidence that doxycycline treatment may be an effective strategy against synucleinopathies.

DOI

10.1101/2020.11.06.371229

 
Pubmed Link

 

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