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Latest Publications


April 2024
BioRxiv
Guan C, Nishi K, Kreis CT, Baeumchen O, Goepfert MC, Schmidt CF
April 2024
BioRxiv
Kaurani L, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Krüger DM, Pena T, Heutink P, Sananbenesi F, Fischer A
April 2024
Cardiovascular Research
Liutkute A, Prosser BL, Voigt N
April 2024
BioRxiv
Fenech EJ, Kupervaser M, Boshnakovska A, Ravid S, Gomes Castro I, Asraf Y, Callegari S, Lenz C, Rehling P, Schuldiner M
April 2024
Cell Death & Disease
Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA
April 2024
BioRxiv
Meissner-Bernard C, Jenkins B, Rupprecht P, Arn Bouldoires E, Zenke F, Friedrich RW, Frank T
April 2024
Nature Communications
Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K
April 2024
Annual Review of Biochemistry
Höbartner C, Bohnsack KE, Bohnsack MT

Authors

Höbartner C, Bohnsack KE, Bohnsack MT

Journal

Annual Review of Biochemistry

Citation

Annu Rev Biochem. 2024 Apr 10.

Abstract

Methylation of RNA nucleotides represents an important layer of gene expression regulation, and perturbation of the RNA methylome is associated with pathophysiology. In cells, RNA methylations are installed by RNA methyltransferases (RNMTs) that are specialized to catalyze particular types of methylation (ribose or different base positions). Furthermore, RNMTs must specifically recognize their appropriate target RNAs within the RNA-dense cellular environment. Some RNMTs are catalytically active alone and achieve target specificity via recognition of sequence motifs and/or RNA structures. Others function together with protein cofactors that can influence stability, S-adenosyl-L-methionine binding, and RNA affinity as well as aiding specific recruitment and catalytic activity. Association of RNMTs with guide RNAs represents an alternative mechanism to direct site-specific methylation by an RNMT that lacks intrinsic specificity. Recently, ribozyme-catalyzed methylation of RNA has been achieved in vitro, and here, we compare these different strategies for RNA methylation from structural and mechanistic perspectives.

DOI

10.1146/annurev-biochem-030222-112310
 
Pubmed Link

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