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Februar 2024
Developmental Cell
Diep DTV, Collado J, Hugenroth M, Fausten RM, Percifull L, Wälte M, Schuberth C, Schmidt O, Fernández-Busnadiego R, Bohnert M
Februar 2024
Cell Reports
Prusty AB, Hirmer A, Sierra-Delgado JA, Huber H, Guenther UP, Schlosser A, Dybkov O, Yildirim E, Urlaub H, Meyer KC, Jablonka S, Erhard F, Fischer U
Februar 2024
BioRxiv
Lange F, Ratz M, Dohrke JN, Wenzel D, Ilgen P, Riedel D, Jakobs S
Februar 2024
Nature Communications
Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, Andreas LB, Griesinger C, Schröder GF
Februar 2024
Cardiovascular Research
Gotthardt M, Lehnart SE
Februar 2024
Nature Structural & Molecular Biology
Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S
Februar 2024
Arxiv
Wang X, Scholand N, Tan Z, Mackner D, Telezki V, Blumenthal M, Schaten P, Uecker M
Februar 2024
Nature Chemistry
Shein M, Hitzenberger M, Cheng T, Rout S, Leitl K, Sato Y, Zacharias M, Sakata E, Schuetz A
Januar 2024
Stem Cell Research
Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP

Authors

Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP

Journal

Stem Cell Research

Citation

Stem Cell Res. 2024 Jan 28;75:103317.

Abstract

Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal connectivity with other excitable cells we established an optogenetic induced pluripotent stem cell line. The SynfChrimson line harbors a stably integrated, fast, red light-activatable channel (f-Chrimson), under the control of synapsin promotor in the AAVS1 locus. Multielectrode array analysis showed that SynfChrimson derived neurons are light-activatable. The specificity of the SynfChrimson function in neurons was validated by cardiomyocyte differentiations which do not respond to light stimulations.

DOI

10.1016/j.scr.2024.103317

 

Pubmed Link

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