Latest Publications

November 2023

Proceedings of the National Academy of Sciences of the United States of America

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Jaime Tobón LM, Moser T

November 2023

BioRxiv

Structure and dynamics of human cardiac fibroblast nanotubes

Schmid-Herbstritt SC, Stief G, Greiner J, Felekary A, Madl J, Zeidler V, Heer J, Iaconianni P, Koch M, Kollmar K, Walz C, Nubling S, Kok T, Pronto JR, Kutschka I, Voigt N, Morgan G, Dienert J, Brox T, Briquez P, Peyronnet R, Rohrbach A, Kohl P, Rog-Zielinska EA

November 2023

BioRxiv

Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina

Krueppel S, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Zapp SJ, Mietsch M, Karamanlis D, Gollisch T

November 2023

Frontiers in Genetics

Unraveling haplotype errors in the DFNA33 locus

Vona B, Regele S, Rad A, Strenzke N, Pater JA, Neumann K, Sturm M, Haack TB, Am Zehnhoff-Dinnesen AG

November 2023

Research Square

Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis

Ricagno S, Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernandez-Busnadiego R, Palladini G

November 2023

BioRxiv

Efficient and sustained optogenetic control of nervous and cardiac systems

Zerche M, Hunniford V, Alekseev A, El May F, Vavakou A, Siegenthaler D, Hueser MA, Kiehn SM, Garrido-Charles A, Alvanos T, Witzke I, Trenholm S, Macé E, Kusch K, Bruegmann T, Wolf BJ, Mager T, Moser T

November 2023

Biorxiv

Prediction mismatch responses arise as corrections of a predictive spiking code

van Driel K, Rudelt L, Priesemann V, Mikulasch FA

November 2023

Neuropediatrics

Tazarotene and Bexarotene Show Efficacy as In Vitro Therapeutic Agents in Multiple Sulfatase Deficiency

Schlotawa l, Matysiak K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T, Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregola J, Pena T, Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French DL, Gelb MH, Gärtner J

November 2023

Brain

Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders

Kaiyrzhanov R, Rad A, Lin SJ, Bertoli-Avella A, Kallemeijn WW, Godwin A, Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Ghayoor Karimiani E, Hempel M, Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi JR, Ganieva M, Fowler B, Aanicai R, Akay Tayfun G, Al Saman A, Alswaid A, Amiri N, Asilova N, Shotelersuk V, Yeetong P, Azam M, Babaei M, Bahrami Monajemi G, Mohammadi P, Samie S, Banu SH, Basto JP, Kortüm F, Bauer M, Bauer P, Beetz C, Garshasbi M, Hameed Issa A, Eyaid W, Ahmed H, Hashemi N, Hassanpour K, Herman I, Ibrohimov S, Abdul-Majeed BA, Imdad M, Isrofilov M, Kaiyal Q, Khan S, Kirmse B, Koster J, Lourenço CM, Mitani T, Moldovan O, Murphy D, Najafi M, Pehlivan D, Rocha ME, Salpietro V, Schmidts M, Shalata A, Mahroum M, Talbeya JK, Taylor RW, Vazquez D, Vetro A, Waterham HR, Zaman M, Schrader TA, Chung WK, Guerrini R, Lupski JR, Gleeson J, Suri M, Jamshidi Y, Bhatia KP, Vona B, Schrader M, Severino M, Guille M, Tate EW, Varshney GK, Houlden H, Maroofian R

November 2023

Nature Structural & Molecular Biology

Structure of the transcribing RNA polymerase II-Elongin complex

Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P

Authors

Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P

Journal

Nature Structural & Molecular Biology

Citation

Nat Struct Mol Biol. 2023 Nov 6.

Abstract

Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM structures of human Elongin bound to transcribing Pol II. The structures show that Elongin subunit ELOA binds the RPB2 side of Pol II and anchors the ELOB-ELOC subunit heterodimer. ELOA contains a ‘latch’ that binds between the end of the Pol II bridge helix and funnel helices, thereby inducing a conformational change near the polymerase active center. The latch is required for the elongation-stimulatory activity of Elongin, but not for Pol II binding, indicating that Elongin functions by allosterically regulating the conformational mobility of the polymerase active center. Elongin binding to Pol II is incompatible with association of the super elongation complex, PAF1 complex and RTF1, which also contain an elongation-stimulatory latch element.

DOI

10.1038/s41594-023-01138-w

Pubmed Link