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10.09.2026

Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase-nuclease coupling

Authors do Prado PFV, Sharma S, Bhatta A, Vuckovic A, Parvizian Marani M, Llarena David AP, Kuhle B, Hillen HS Journal BioRxiv Citation bioRxiv 2026.09.06.749684. Abstract RNA degradation shapes cellular and organellar gene expression. In human mitochondria, this process is mediated by a dedicated degradosome comprising the helicase SUV3 and
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09.09.2026

Guanosine 10 methylation by TRMT11-TRMT112 optimizes human mitochondrial tRNAs for efficient translation

Authors Petrosyan J, Yilmaz M, Scheitl CPM, Lemus-Diaz N, Boshnakovska A, Tay LLE, Hu W, Beine-Golovchuk O, Touboul D, Richter-Dennerlein R, Höbartner C, Graille M, Rehling P, Bohnsack KE Journal Nucleic Acids Research Citation Nucleic Acids Res. 2026 Aug 24;54(16):gkag859. Abstract Modified nucleotides are essential determinants of RNA function, and
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03.09.2026

Nanobodies Equipped with HaloTag Enable Scalable Fluorescence-Lifetime Multiplexing

Authors Albert L, Basak S, Körner H, Oleksiievets N, Mougios N, Cotroneo ER, Frei MS, Enderlein J, Broichhagen J, Simeth NA, Tsukanov R, Opazo F Journal ACS Nano Citation ACS Nano 2026 Abstract Fluorescence lifetime (FL) is a robust strategy for multiplexed imaging; however, variability in fluorophores’ local microenvironment when
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03.09.2026

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Authors Quinn CJ, Lahiri SK, Quick AP, Brandenburg S, Uhlenkamp D, Jain A, Moreira LM, Jung SY, Reilly S, Sayeed R, Krasopoulos G, Lehnart SE, Wehrens XHT Journal IJC Heart & Vasculature Citation IJC Heart & Vasculature 66 (2026) 102005. Abstract Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric
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02.09.2026

Innervated human cardiac muscle model reveals sympathetic drivers of KCNH2-associated arrhythmias

Authors Schneider LV, Setya MG, Bao G, Härtter D, Methi A, Krüger D, Schreiber MK, Jensen O, Kanari E, Schmoll KA, Telugu NS, Sakib S, Kim ES, Fahud AL, Novin M, Seedorf A, Diecke S, Fischer A, Liaw NY, Zimmermann WH, Zafeiriou MP Journal Nature Communications Citation Nat Commun. 2026
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29.08.2026

Multimodal quantitative MRI finds early brain changes in asymptomatic X-linked adrenoleukodystrophy

Authors Meier K, Sahoo P, Marten LM, Gkalimani I, Helms G, Dechent P, Rosewich H, Dreha-Kulaczewski S, Gärtner J Journal Brain Communications Citation Brain Commun. 2026 Aug 29;8(5):fcag311. Abstract Adrenoleukodystrophy (ALD) is an X-linked recessive disease caused by defects in the ABCD1 gene, leading to the accumulation of very long-chain
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27.08.2026

Signatures of Hebbian plasticity in the nanoscale morphodynamics of cortical spines

Authors Soltanipour M, Nagel A, Willig KI, Wolf F Journal BioRxiv Citation bioRxiv 2026.08.27.747454. Abstract The size, shape, and nanoscale organization of synaptic spines are predictive of physiological synaptic strength and thus key to connectome-based neural circuit models. In the intact brain, spine size and shape undergo continuous morphological remodeling.
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26.08.2026

Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy

Authors Habenstein F, Jensen N, Stumpf D, Chizhik AI, Leutenegger M, Chang J, Fognini A, Qin-Dregely J, Zadeh IE, Kirck LL, Enderlein J, Inamdar K, Hell SW, Jakobs S Journal Proceedings of the National Academy of Sciences of the USA Citation Proc Natl Acad Sci U S A. 2026 Sep;123(35):e2533451123.
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26.08.2026

Molecular basis for a Ca2+ binding hierarchy in the EF-hand motifs of CaBP2

Authors Motosugi R, Walinda E, Kim T, Mateias AL, Pallinger T, Prajapati S, Morimoto D, Kim M, Rankovic V, Griesinger C, Tittmann K, Pangrsic T, Sakata E Journal Journal of Biological Chemistry Citation J Biol Chem. 2026 Aug 26:113492. Abstract Calcium binding protein 2 (CaBP2), a member of the calmodulin
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26.08.2026

Systematic Review and Transcriptomic Meta-analysis of Environmental Enrichment Reveal Core Molecular Programs of Brain Plasticity

Authors Kurowska M, Miozzo F, Schroeder R, Machnicka MA, Pérez-González R, Merienne K, Fischer A, Barco A, Boutillier AL, Wilczyński B Journal Molecular Neurobiology Citation Mol Neurobiol. 2026 Aug 26;63(1):857. Abstract Environmental enrichment (EE) paradigms in rodents have long demonstrated that enhanced sensory, cognitive, social, and motor stimulation positively impacts
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