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01.11.2026

Correlative X-ray imaging and fluorescence microscopy in hydrated environments

Authors Sinha M, Yu B, Mendes Da Silva R, Rölleke U, Luley P, Tiburcy M, Zimmermann WH, Burghammer M, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2026 Nov 1 Abstract Imaging cellular organization in its native state is essential for understanding how the molecular architecture governs
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23.10.2026

Arrhythmic events and genetic variants as drivers for Takotsubo Syndrome: a patient-specific atrial stem-cell model

Authors Brand C, Zinke C, Syed Ali G, Hübscher D, Ajmail K, Seedorf A, Steinker P, Treu F, Jung P, Eberl H, Li Y, Dybkova N, Feld L, Ghadri JR, Templin C, Sossalla S, Maack C, Voigt N, Nikolaev VO, Wollnik B, Streckfuss-Bömeke K Journal Signal Transduction and Targeted Therapy
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23.10.2026

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Diniz AM, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal Molecular Therapy Citation Mol Ther. 2026 Oct 23:S1525-0016(26)00883-X. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy
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22.10.2026

Multichannel optical cochlear implants enable spectrally distinct auditory activity

Authors Albrecht N, Koert E, Vavakou A, Roos L, Jablonski L, Marcoleta JP, Cardona Audi J, Alfken J, Klein E, Ruther P, Mager T, Kusch K, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2026 Oct 22 Abstract When hearing fails, cochlear implants (CIs) restore auditory perception. Yet,
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21.10.2026

In situ radiation damage tracking during scanning small-angle X-ray scattering

Authors Yu B, Mendes Da Silva R, Sinha M, Rölleke U, Burghammer M, Köster S Journal BioRxiv Citation bioRxiv 2026.10.20.760376 Abstract Due to the high penetration power of X-rays, X-ray imaging techniques have been employed to image cellular architecture. Among these techniques, scanning small-angle X-ray scattering (SAXS) is a powerful
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20.10.2026

Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression

Authors Mücher B, Garrido-Charles A, Wietek J, Köhler I, Grömmke M, Frischmuth T, Cyganek L, Rost BR, Bruegmann T, Schmitz D, Dalkara D, Wahle P, Siveke I, Herlitze S Journal Science Signaling Citation Sci Signal. 2026 Oct 20;19(960):eadw4374. Abstract Stimulation of G protein-coupled receptors (GPCRs) that couple to Gi/o leads
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19.10.2026

Structural order emerges without mechanical order inside living cells

Authors Eskandari MA, Ulmer S, Carranza Zuñiga D, Lambert S, Dey S, Marcelli C, Sarparandeh H, Haag R, Marx D, Luber M, Vos BE, Schmitzer B, Köster S, Betz T Journal BioRxiv Citation bioRxiv 2026.10.15.759452 Abstract Intracellular organization is vital for cell function, and disruption of organelle positioning is connected
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14.10.2026

LightSuite: scalable atlas registration and cell detection across the central nervous system

Authors Karamanlis D, Xie Y, Foucher CG, Alappat M, Masood A, Dimitropoulou I,Pivron LAF, Martínez de Paz JM, Macé E, Gaspari S, El-Boustani S Journal BioRxiv Citation bioRxiv 2026.10.13.757638 Abstract Deciphering brain-wide circuits requires large animal cohorts, yet computational bottlenecks in atlas registration and whole-volume cell detection reduce precision, reproducibility,
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24.09.2026

Force generation of cardiomyocytes in engineered environments

Authors Sinha M, Rölleke U, Haag R, Tiburcy M, Blumberg J, Schwarz US, Zimmermann WH, Köster S Journal BioRxiv Citation bioRxiv 2026.09.24.754056 Abstract Cardiomyocyte contraction is essential for the pumping action of the heart and deteriorates after myocardial damage, either as a consequence of irreversible cardiomyocyte injury or stiffening of
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19.09.2026

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

Authors Akerman E, Capel RA, Rog-Zielinska EA, Winbo A, Aston D, Falter F, Bin Abdul Mu-U-Min R, Read MJ, Bose SJ, Swietach P, Wang J, Corbett AD, Koschinski A, Calamaio S, Melgari D, Prevostini R, Rivolta I, Ayagama T, Jenkin I, Simon JN, Fakuade FE, Pronto JR, Sharma P, Melia
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