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16.01.2026

DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue

Authors Häring M, Zhang Y, Zhang N, Allgeyer ES, Richens JH, Sirinakis G, Lv Z, St Johnston D, Wolf F, Großhans J, Kong D Journal Biophysical Journal Citation Biophys J. 2026 Jan 16:S0006-3495(26)00041-X. Abstract Cell junction remodeling is central to epithelial morphogenesis and tissue rheology, and depends on the interplay
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13.01.2026

Establishing synthetic ribbon-type active zones in a heterologous expression system

Authors Kapoor R, Do TT, Schwenzer N, Petrovic A, Dresbach T, Lehnart SE, Fernández-Busnadiego R, Moser T Journal eLife Citation Elife. 2026 Jan 13;13:RP98254. Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ)
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12.01.2026

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Authors Haydar S, Bednarz R, Laurette P, Sobitov I, Díaz I Pedrosa N, Videm P, Lueneburg T, Kuß S, Lahm H, Dreßen M, Krane M, Schmidt C, Grüning BA, Voigt N, Streckfuss-Bömeke K, Gilsbach R Journal Nature Communications Citation Nat Commun. 2026 Jan 12;17(1):117. Abstract Cis-regulatory elements (CREs) are noncoding
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12.01.2026

Molecular genotype-phenotype correlation in ACTB- and ACTG1-related non-muscle actinopathies

Authors Di Donato N; NMA Consortium; Thom A, Rump A, Greve JN, Cadiñanos J, Calabro S, Cathey S, Chung B, Cope H, Costales M, Cuvertino S, Dinkel P, Erripi K, Fry AE, Garavelli L, Hoffjan S, Janzarik WG, Kreimer I, Mancini G, Marin-Reina P, Meinhardt A, Niehaus I, Pilz D,
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09.01.2026

Restoring Shugoshin 1 reduces chromosome errors in human eggs

Authors Schuh M, Saha D, Manshaei S, Cavazza T, Holubcova S, Maierova B, Zielinska AP, Wartosch L, Blaney M, Elder K Journal BioRxiv Citation bioRxiv 2026.01.08.698387. Abstract Aneuploidy in human eggs, which rises sharply with age, is a leading cause of infertility, IVF failure, and miscarriage. This age-related aneuploidy is
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05.01.2026

Quick Adaptive Ternary Segmentation: An Efficient Decoding Procedure For Hidden Markov Models

Authors Mösching A, Li H, Munk A Journal Journal of Computational and Graphical Statistics Citation Journal of Computational and Graphical Statistics, 1–15. Abstract Hidden Markov models (HMMs) are characterized by an unobservable Markov chain and an observable process—a noisy version of the hidden chain. Decoding the original signal from the
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01.01.2026

Versatile Microfluidics Platform for Enhanced Multitarget Super-Resolution Microscopy

Authors Basak S, Vu KC, Mougios N, Oleksiievets N, Pollack YG, Brandenburg S, Opazo F, Lehnart SE, Enderlein J, Tsukanov R Journal ACS Nano Citation ACS Nano. 2026 Jan 1. Abstract DNA-based Point Accumulation for Imaging in Nanoscale Topography (DNA-PAINT) is a powerful variant of single-molecule localization microscopy (SMLM) that
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29.12.2025

Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

Authors Habeck M, Saleem HN, Plota D, Cheruiyot C, Kohl T, Lehnart SE, Jakobs S, Ebert A Journal Biological Chemistry Citation Biol Chem. 2025 Dec 29. Abstract In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new
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27.12.2025

Unlocking microglia pyroptosis in a model of type I interferon-driven neuroinflammation: lessons from Rnaset2-/- mice.

Authors Wendland K, Irsfeld M, Schreiber K, Ternka K, Stadelmann C, Nessler S, Gärtner J, Kettwig M Journal Cell Death & Disease Citation Cell Death Dis. 2025 Dec 27. Abstract RNaseT2-deficient cystic leukoencephalopathy (CLE) presents with severe psychomotor retardation, cystic brain lesions, white matter alterations, and cerebral atrophy. The Rnaset2−/−
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26.12.2025

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Authors Flores-León M, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2025 Dec 26. Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies
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