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06.08.2026

“Heart-in-the-dish” models identify mechanisms of diastolic dysfunction

Authors Dittrich GM, Zimmermann WH. Journal Cell Stem Cell Citation Cell Stem Cell. 2026 Aug 6;33(8):1243-1245. Abstract Modeling of cardiac pathologies in tissue-engineered models is coming of age. Two independent studies by Reid et al.1 and Tani et al.2 present in-depth multi-phenomics data from a human cardiac organoid (hCO) model
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03.08.2026

A microfluidics platform for studying ion and solute transport by isolated synaptic vesicles

Authors Upmanyu N, Olsthoorn L, Leon S, Sambandan S, Perego E, Mimoso T, Socrier L, Cretich M, Chiari M, Steinem C, Köster S, Jahn R Journal Colloids and Surfaces B: Biointerfaces Citation Colloids Surf B Biointerfaces. 2026 Aug 3;268(Pt 2):116020. Abstract Loading of synaptic vesicles with neurotransmitters, an essential step
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31.07.2026

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

Authors Plota D, Nosheen Saleem H, Lin KH, Wali R, Cheruiyot C, Münzel L, Hutschenreiter T, Tiburcy M, Meyer T, Habeck M, Wiedmann F, Schmidt C, Zimmermann WH, Ebert A Journal Journal of Translational Medicine Citation J Transl Med (2026). Abstract Background: Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are now widely
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28.07.2026

Desmin Mutations Disrupt Filament Elongation and Drive Polymorphic Aggregation

Authors Schween L, Burchert JP, van der Heyden M, Schultheis D, Mücke N, Köster S, Strelkov SV, Herrmann H, Fabry B Journal BioRxiv Citation bioRxiv 2026.07.22.740046. Abstract In muscle cells, desmin intermediate filaments form a cytoskeletal network that maintains the structural integrity and mechanical coupling of myofibrils. Dominant missense mutations
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23.07.2026

Focal astrocyte loss reveals nuclear translocation during lesion repopulation

Authors Herwerth M, Wyss MT, Schmid NB, Lasne A, Condrau J, Ravotto L, Mateos Melero JM, Kaech A, Bredell G, Thomas C, Kim R, Kukanja P, Korobeynyk VL, Stadelmann C, Misgeld T, Bennett JL, Jessberger S, Saab AS, Liddelow SA, Weber B Journal Nature Neuroscience Citation Nat Neurosci. 2026 Jul
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17.07.2026

Structure and dynamics of the Nipah virus RNA-dependent RNA polymerase

Authors Sala FA, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2026 Jul 17:S0968-0004(26)00203-3. Abstract Nipah virus (NiV) is a highly pathogenic, nonsegmented, negative-sense RNA virus (nsNSV) from the Mononegavirales order that causes frequent outbreaks, with no approved treatment available. Replication and transcription of its genome are
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14.07.2026

RBM20 variants disrupt Ca2+ handling and metabolism in dilated and non-compaction cardiomyopathy stem cell models

Authors Rebs S, Sedaghat-Hamedani F, Kayvanpour E, Eberl H, Berečić B, Dudek J, Wagensohner N, Seedorf A, Unsöld JK, Hübscher D, Reich C, Klein T, Doose S, Nikolaev VO, Buchwald T, Wagdi A, Kohlhaas M, Dybkova N, Morais Costa P, Guan K, Hasenfuss G, Rog-Zielinska EA, Sossalla S, Sauer M,
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09.07.2026

The lncRNA Gm16685/MITA1 modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signaling

Authors Fuchs U, Schroeder S, Pena T, Krueger DM, Burkhardt S, Schuetz AL, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736437. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of cellular identity and disease associated gene expression programs, yet their role in astrocyte reactivity remains poorly understood.
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07.07.2026

Inferring Cooperativity From Pooled Measurements

Authors Requardt R, Li H Journal Arxiv Citation arXiv:2607.03088 Abstract In many modern experiments, latent interactions drive multicomponent stochastic systems, yet the data are available only as pooled measurements that obscure these dependencies. Whether such interactions can be identified and inferred from aggregate signals remains largely unexplored. Motivated by multi-channel
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03.07.2026

Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes

Authors Fuchs U, Schroeder S, Pena t, Krueger DM, Burkhardt S, Schuetz AL, Hempel N, Gisa V, Taghavi T, Cortes J, Gertig M, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736275. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their
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