Nature Communications

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21.05.2026

Hierarchical multi-timescale structural dynamics of the disordered N-terminal of p53

Authors Szöllősi D, Pratihar S, Mukhopadhyay D, Rout AK, Han M, Reddy GJ, Ebersberger N, Becker S, Nagy G, Rauscher S, Lee D, Klement R, Griesinger C, Grubmüller H Journal Nature Communications Citation Nat Commun. 2026 May 21 Abstract Most natively folded proteins exhibit a unique spatial structure, which undergoes
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18.05.2026

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM

Authors Yoshida M, Gersteuer F, Berendes O, Fujiwara K, Safdari HA, Paternoga H, Takada H, Obana N, Grubmüller H, Bock LV, Wilson DN, Chiba S Journal Nature Communications Citation Nat Commun. 2026 May 18;17(1):4202. Abstract Ribosome arrest peptides undergo programmed translational stalling in response to changes in the cellular environment
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28.03.2026

Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness

Authors Kahland T, Lindenwald DL, Jeschke M, Kusch K, Tkachenko Eikel O, Uhl M, Rüger N, Drummer C, Wolf B, Benseler F, Brose N, Behr R, Moser T Journal Nature Communications Citation Nat Commun 17, 3033 (2026). Abstract Disabling hearing impairment is a common human sensory deficit. OTOF is a
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12.01.2026

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Authors Haydar S, Bednarz R, Laurette P, Sobitov I, Díaz I Pedrosa N, Videm P, Lueneburg T, Kuß S, Lahm H, Dreßen M, Krane M, Schmidt C, Grüning BA, Voigt N, Streckfuss-Bömeke K, Gilsbach R Journal Nature Communications Citation Nat Commun. 2026 Jan 12;17(1):117. Abstract Cis-regulatory elements (CREs) are noncoding
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28.08.2025

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Authors Heim A, Cheng S, Orth J, Stengel F, Schuh M, Mayer TU Journal Nature Communications Citation Nat Commun. 2025 Aug 28;16(1):8051. Abstract Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
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12.07.2025

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis

Authors Chouaib AA, Chang HF, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U Journal Nature Communications Citation Nat Commun. 2025 Jul 12;16(1):6450. Abstract Activity recognition in live-cell imaging is labor-intensive
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10.07.2025

Super-resolution microscopy of mitochondrial mRNAs

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal Nature Communications Citation Nat Commun. 2025 Jul 10;16(1):6391. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are
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01.06.2025

Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Authors Han M, Frieg B, Matthes D, Leonov A, Ryazanov S, Giller K, Nimerovsky E, Stampolaki M, Xue K, Overkamp K, Dienemann C, Riedel D, Giese A, Becker S, de Groot BL, Schröder GF, Andreas LB, Griesinger C Journal Nature Communication Citation Nat Commun. 2025 Oct 3;16(1):8850. Abstract Alzheimer’s disease
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17.04.2025

Coupling of ribosome biogenesis and translation initiation in human mitochondria

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we
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13.03.2025

A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics

Authors Maupérin M, Sun Y, Glandorf T, Oswald TA, Klatt N, Geil B, Mutero-Maeda A, Méan I, Jond L, Janshoff A, Yan J, Citi S Journal Nature Communications Citation Nat Commun. 2025 Mar 13;16(1):2514. Abstract Cytoplasmic β- and γ-actin isoforms, along with non-muscle myosin 2 isoforms, are tightly regulated in
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