2026

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Prof. Dr. Rubèn Fernández-Busnadiego, leader of the working group “Structural Cell Biology” at the Department of Neuropathology at the University Medical Center Göttingen (UMG), and Dr. Kenneth Ehses, postdoc at the Institute for Neuropathologyat UMG and member of the Hertha Sponer College (from left to right). Photos: mbexc/swen pförtner

16.03.2026

High-resolution electron microscopy sheds light into the cellular responses to stress

An international team led by researchers from the University Medical Center Göttingen (UMG) has used advanced electron microscopy technologies to capture key cellular mechanisms of stress resistance with near-atomic precision. They were able to show that the protein mHsp60, which helps other proteins to adopt their functional form, remodels its
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There is a glimmer of hope for heart patients. A team in Göttingen conducted experiments on a rabbit heart suspended in a nutrient solution. This research sheds light on what happens in the heart muscle during cardiac arrhythmias. Based on these findings, the researchers are developing gentler treatments. © Efimov, Nikolski & Salama, Circ. Res. (2004) / Christoph, Schröder-Schetelig, S.L. (2017)

16.03.2026

Clock generator for the heart

Cardiac arrhythmias are one of the main causes of death in industrialised countries. These are often treated with defibrillators, which deliver painful electric shocks. However, physicist and MBExC member Stefan Luther has found a gentler way to stop these arrhythmias. He is now working with industry partners to bring the
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14.03.2026

Neuid: A Novel Neuron-Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer’s Disease

Authors Pradhan R, Petrovic Z, Sadman Sakib M, Schröder S, Manfred Krüger D, Pena T, Diniz E, Burkhardt S, Schütz AL, Gisa V, Grzadzielewska I, Toischer K, Stein TD, Krzysztof Blusztajn J, Delalle I, Radulovic J, Sananbenesi F, Fischer A Journal Advanced Science (Weinheim) Citation Adv Sci (Weinh). 2026 Mar
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12.03.2026

Neuroinflammatory profiles and cellular localization of TNF-α associated with chronic vanadium neurotoxicity

Authors Folarin RO, Olopade FE, Gilbert TT, Ladagu AD, Dos Santos PIP, Mustapha OA, Kpasham LZ, Outeiro TF, Olopade JO Journal Metabolic Brain Disease Citation Metab Brain Dis. 2026 Mar 12;41(1):52. Abstract Vanadium, an environmental pollutant, is closely associated with neurodegeneration, primarily through oxidative damage and chronic neuroinflammation. While chronic
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10.03.2026

Mitotic BLM functions are required to maintain genomic stability

Authors Hamann TE, Wieland A, Mohseni F, Vukušić K, Tirincsi A, Wardenaar R, Losito M, Harmsen I, Gönenc II, Wollnik B, Foijer F, Tolić IM, Storchová Z, Räschle M Journal Nucleid Acid Research Citation Nucleic Acids Res. 2026 Feb 24;54(5):gkag199. Abstract The BLM helicase is a critical genome maintenance protein
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10.03.2026

Visualizing the multidimensional landscape of biological variation in modern microscopy

Authors Müller GF, Göpel T, Scherf N, Huisken J. Journal Frontiers in Bioinformatics Citation Front Bioinform. 2026 Mar 10;6:1757489. Abstract Variation is a foundational biological principle that has historically been marginalized-both due to limited experimental accessibility and because of idealized, stereotypic blueprints rooted in essentialist thinking. With the advent of
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09.03.2026

Arousal elicits a brain-wide hemodynamic wave independent of locus coeruleus noradrenergic tone

Authors Martinez de Paz JM, Mayer JL, Wanken P, Rodrigues Apgaua B, Ablitip A, Behera L, Macé E Journal BioRxiv Citation bioRxiv 2026.03.06.710089. Abstract Arousal fluctuations during wakefulness have a major impact on physiology and behavior, including perception and task performance. Arousal is also known to be a strong modulator
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09.03.2026

Image modifications reduce differences in natural-image encoding by retinal ganglion cells between natural and optogenetic stimulation

Authors Ramakrishna V, Gollisch T Journal BioRxiv Citation bioRxiv 2026.03.06.710066. Abstract Photoreceptor degeneration is among the leading causes of blindness and optogenetics as a potential therapeutic measure has garnered much attention over recent years. In this approach, light-sensitive molecules like Channelrhodopsin-2 (ChR2) are inserted into neurons in the retina to
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06.03.2026

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

Authors Ehses K, López-Alonso JP, Antico O, Azem A, Muqit MMK, Ubarretxena-Belandia I, Fernández-Busnadiego R Journal Science Advances Citation Sci Adv. 2026. Sci Adv. 2026 Mar 6;12(10):eaed3579. Abstract Cells have evolved organelle-specific responses to maintain protein homeostasis (proteostasis). During proteostatic stress, mitochondria down-regulate translation and enhance protein folding, yet the
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