“Heart-in-the-dish” models identify mechanisms of diastolic dysfunction

Authors

Dittrich GM, Zimmermann WH.

Journal

Cell Stem Cell

Citation

Cell Stem Cell. 2026 Aug 6;33(8):1243-1245.

Abstract

Modeling of cardiac pathologies in tissue-engineered models is coming of age. Two independent studies by Reid et al.1 and Tani et al.2 present in-depth multi-phenomics data from a human cardiac organoid (hCO) model and explore hCOs and engineered heart tissues (EHTs) for modeling of diastolic dysfunction.

DOI

10.1016/j.stem.2026.07.007
 
Pubmed Link