2026

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06.03.2026

A transition-prone brain state precedes spontaneous behavioral switching

Authors Wanken P, Edelman BJ, Behera L, Martinez de Paz JM, McCarthy PT, Macé E Journal BioRxiv Citation bioRxiv 2026.03.06.709845. Abstract Animals exhibit behavior in the absence of external stimuli or explicit tasks. Is the initiation of such spontaneous behavior shaped by internal brain states in a predictable manner? If
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Heart muscle cells cultivated in the laboratory from iPS cells: The image shows the structure of the muscle fibres. The project at Göttingen University Medical Centre (UMG), funded by the zukunft.niedersachsen programme, works with such patient-specific models. Image: umg/lukas cyganek

03.03.2026

Precision medicine for rare heart diseases

Göttingen research receives millions in funding   The University Medical Center Göttingen (UMG) is receiving over one million euros from the zukunft.niedersachsen funding programme for a gene therapy project to treat Noonan syndrome. The focus is on developing individually tailored therapies for children with heart disease.   Rare diseases often
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Super-resolution image of cytoskeleton and focal adhesion proteins taken using the new versatile and cost-effective microfluidics system. The “overlay” of all the different target molecules reveals exquisite and complex detail up to 100 times sharper than conventional microscopy. Photo: adapted from the original publication in ACS Nano (2026). DoI: 10.1021/acsnano.5c18697

03.03.2026

Tiny flows, big insights: microfluidics system boosts super-resolution microscopy

International research team led by Göttingen University design versatile imaging system   Understanding how cells are organized and how their molecular components interact in a coordinated and cooperative manner is a central goal of modern life sciences. To answer these questions, researchers need to observe many structures inside the same
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03.03.2026

Mechanism of human tRNA 3′CCA maturation

Authors Kuhle B, Krebs L, Bhatta A, Dennerlein S, Rehling P, Hillen H Journal BioRxiv Citation bioRxiv 2026.03.02.709036. Abstract The non-templated addition of the 3′CCA end is the final universal step of tRNA maturation. In humans, 3′CCA addition on nuclear- (nu-tRNA) and mitochondria-encoded tRNAs (mt-tRNA) is catalyzed by a single
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02.03.2026

Nanobodies equipped with HaloTag variants enable rapid and straightforward one-step immunofluorescence lifetime multiplexing

Authors Albert L, Basak S, Koerner H, Oleksiievets N, Mougios N, Cotroneo ER, Frei MS, Enderlein J, Broichhagen J, Simeth NA, Tsukanov R, Opazo F Journal BioRxiv Citation bioRxiv 2026.03.02.709025. Abstract Multiplexed fluorescence imaging is limited by spectral overlap, whereas fluorescence lifetime provides an orthogonal encoding dimension. We replace genetically
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The team behind Ovo Labs (from left)- Dr. Agata Zielinska, Prof. Dr. Melina Schuh, and Dr. Oleksandr Yagensky. © Irene Böttcher-Gajewski _ Max Planck Institute for Multidisciplinary Sciences

23.02.2026

Ovo Labs receives Max Planck Startup Award of the Stifterverband 2026

This year’s Max Planck Start-up Award of the Stifterverband honours the work of Ovo Labs. Founded in 2025 as a spin-off from the Max Planck Institute for Multidisciplinary Sciences in Göttingen, the young biotech company develops novel therapeutics designed to improve the quality of human oocytes (egg cells). The prize,
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20.02.2026

Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer

Authors Maestro-López M, Cheng TC, Muntaner J, Menéndez M, Alonso M, Schweitzer A, Ishizaka M, Tomko RJ Jr, Cuéllar J, Valpuesta JM, Sakata E Journal Science Advances Citation Sci Adv. 2026 Feb 20;12(8):eadz3026. Abstract Coupling between the chaperone and degradation systems, particularly under stress, is essential for eliminating unfolded proteins.
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20.02.2026

The Nonadiabatic Nature of the Substituent Effects in Azobenzene

Authors van der Wal JJ, Peshkov RY, Steen JD, Simeth NA, Crespi S Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2026 Feb 20:e23613. Abstract The mechanism of thermal Z → E isomerization in azobenzenes has been debated for nearly a century, with inversion, rotation,
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16.02.2026

Detection and characterization of physiological network interactions in pulsatile motion of cranial blood vessels using real-time MRI

Authors von der Ohe T, Telezki V, Hofer S, Dechent P, Uecker M, Bähr M, Luther S, Parlitz U Journal Frontiers in Network Physiology Citation Front Netw Physiol. 2026 Feb 16;6:1701638. Abstract We present a robust method to assess pulsatile motion of larger cranial blood vessels in the human brain
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13.02.2026

Mechanisms and disease relevance of mitochondrial translation in humans

Authors Richter-Dennerlein R, Dopico XC, Rorbach J Journal Nature Reviews. Molecular Cell Biology Citation Nat Rev Mol Cell Biol. 2026 Feb 13. Abstract Human mitochondrial ribosomes (mitoribosomes) synthesize the 13 mitochondrial-encoded proteins of the oxidative phosphorylation machinery in a coordinated manner, ensuring proper folding of nascent peptides into the inner
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