2026

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03.07.2026

Für Herz und Hirn

Interview zum Hertha Sponer College im faktor Magazin: Im Hertha-Sponer-College (HSC) in Göttingen wächst eine neue Generation von Spitzenforschern heran – mit einem deutschlandweit einzigartigen Konzept. Das HSC ist Teil des Exzellenzclusters „Multiscale Bioimaging: Von molekularen Maschinen zu Netzwerken erregbarer Zellen“ (kurz MBExC) der Georg-August-Universität Göttingen und der Universitätsmedizin Göttingen
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Das Herzpflaster wird aus induzierten pluripotenten Stammzellen gewonnenen Herzmuskel- und Bindegewebszellen in einem Kollagen-Hydrogel hergestellt. Grafik: umg/eva meyer-besting

03.07.2026

Podcast: Wozu brauchen wir ein Pflaster fürs Herz?

Rabea Hinkel und Wolfram-Hubertus Zimmermann sprechen im Podcast Tonspur Wissen der Leibniz-Gemeinschaft über das Herzpflaster   Über drei Millionen Menschen in Deutschland leiden an einer Herzmuskelschwäche häufig ausgelöst durch verkalkte Herzkranzgefäße und damit einhergehende Herzinfarkte, die das Herzmuskelgewebe nachhaltig schädigen. Die Therapiemaßnahmen sind bisher stark eingeschränkt und im schlimmsten Fall
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03.07.2026

Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes

Authors Fuchs U, Schroeder S, Pena t, Krueger DM, Burkhardt S, Schuetz AL, Hempel N, Gisa V, Taghavi T, Cortes J, Gertig M, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736275. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their
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01.07.2026

Artificial Intelligence for Discovery in Life Sciences

Authors Chanda S, Rizzoli SO, Shaib AH Journal Bioconjugate Chemistry Citation Bioconjug Chem. 2026 Jul 1. Abstract Artificial intelligence is becoming a transformative tool in life sciences, not just by improving the results of existing technologies but also by introducing fundamental new ways of discovery. Initially applied to denoising, segmentation,
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26.06.2026

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease

Authors da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez D, Klein R, Giese A, Griesinger C, Dudanova I Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2026 Jun 26. Abstract Huntington’s disease (HD) is a hereditary movement disorder caused by a CAG repeat expansion in
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24.06.2026

Molecular mechanisms of E-Syt-mediated stress resistance

Authors Benitez-Fuente F, Collado J, Morello-Lopez J, Pagano-Marquez R, Ruiz-Lopez N, Keller J, Botella MA, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2026.06.23.733366. Abstract Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma membrane (PM) enable direct intermembrane exchange of signals and metabolites. The Extended Synaptotagmins (E-Syts) are
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22.06.2026

Distributed representations of chemosensory valence in a naive vertebrate brain

Authors Jenkins B, Frank T Journal BioRxiv Citation bioRxiv 2026.06.17.732810. Abstract Chemical cues guide essential behaviors by signaling food, danger, and social information. A major dimension of chemosensory processing is valence, which biases animals toward approach or avoidance, yet its brain-wide organization in vertebrates remains unclear. Here, we used larval
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17.06.2026

Deep learning for interactive and automated inner retinal layer segmentation in OCT images of patients with retinitis pigmentosa using limited training data

Authors Laurence SD, Schilling M, Grimm NA, Mace E, Bemme S, Pape C Journal MedRxiv Citation medRxiv 2026.06.16.26355668. Abstract Purpose: New therapeutic strategies such as optogenetics have created a need for accurate tracking of inner retina degeneration in Retinitis pigmentosa (RP) patients. We introduce two tailored deep learning models to
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17.06.2026

Targeting intracellular cholesterol imbalance rescues sarcomere-ER contact site signaling and ER remodeling in dilated cardiomyopathy

Authors Ignatyeva N, Cheruiyot C, Saleem HN, Wali R, Plota D, Zhang W, Schön S, Brandenburg S, Yang Z, Steyer A, Urlaub H, Rasmussen T, Mogensen J, Pronto JRD, Döring Y, Radke MH, Shcherbata H, Lehnart SE, Janshoff A, Sossalla S, Ruhwedel T, Moebius W, Toischer K, Brügger B, Haucke
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15.06.2026

LRRK2/LRRK1 interactions modulate Rab7 activity and inhibit lysosomal exocytosis

Authors Merghani M, Gerhardt E, Hesse M, Fahlbusch C, Boecker CA, Outeiro TF Journal BioRxiv Citation bioRxiv 2026.06.12.731951. Abstract Mutations in the LRRK2 gene are the most common genetic cause of both familial and sporadic Parkinson’s disease (PD). LRRK2 belongs to the leucine-rich repeat kinase (LRRK) family. Two members of
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