2026

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30.04.2026

Neue Perspektive bei Noonan-Syndrom

Ein Göttinger Forschungsteam unter der Leitung von MBExC Mitglied Dr. Lukas Cyganek, Leiter der Stem Cell Unit in der Klinik für Kardiologie und Pneumologie der Universitätsmedizin Göttingen (UMG), konnte zeigen, dass insbesondere Bindegewebszellen des Herzens, sogenannte kardiale Fibroblasten, eine zentrale krankheitsverursachende Rolle spielen. Bei erkrankten Menschen produzieren diese Zellen vermehrt
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28.04.2026

Universal approach to wave-optical calculations of point spread functions in microscopy (and beyond)

Authors Gligonov I, Loetgering L, Tenopala-Carmona F, Hsieh CL, Gregor I, Enderlein J Journal BioRxiv Citation bioRxiv 2026.04.28.721333 Abstract Optical microscopy is fundamental to modern life-science research, yet interpreting its results requires precise modelling of point spread functions (PSFs) within complex environments. This manuscript introduces a versatile and efficient approach
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24.04.2026

Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: Findings from the Rhineland Study

Authors Melas K, Talevi V, Imtiaz MA, Krüger DM, Pena-Centeno T, Fischer A, Aziz NA, Breteler MMB Journal Molecular Psychiatry Citation Mol Psychiatry. 2026 Apr 24. Abstract MicroRNAs (miRNAs) have been linked to brain disorders, but their relations with hippocampal structure and atrophy remain unexplored. As the hippocampus is pivotal
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20.04.2026

Labeling and imaging of neurons with a genetically encoded autonomous bioluminescence system

Authors Brinker T, Günther A, Kiszka KA, Rhee JS, Gregor C Journal Scientific Reports Citation Sci Rep. 2026 Apr 20;16(1):12892. Abstract The bacterial bioluminescence system, consisting of a luciferase and enzymes for intracellular luciferin synthesis, enables autonomous bioluminescence imaging of mammalian cells. Its continuous light emission without the need for
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18.04.2026

The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP

Authors Rout SR, Kulke M, Droemer M, Wendel M, Cheng TC, Mauck TA, Asgari S, Nemec AA, Shein M, Sato Y, Fukai S, Witte G, Tomko Jr. RJ, Stengel F, Zacharias M, Schuetz AK, Sakata E Journal BioRxiv Citation bioRxiv 2026.04.16.718620 Abstract The multifunctional AAA+ ATPase p97/VCP is a pivotal
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16.04.2026

Distributional Convergence of Empirical Entropic Optimal Transport and Statistical Applications

Authors Arenas-Velilla S, Munk A, Rodríguez LA Journal Arxiv Citation arXiv:2604.12940 Abstract Recently, the statistical properties of empirical Entropic Optimal Transport (EOT) have attracted great interest, as this quantity has been shown to be useful for complex data analysis, among other reasons due to its computational efficiency. In several applications,
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16.04.2026

Self-propelled particles driven by light

Authors Fischer J, Jurado A, Betz T Journal Arxiv Citation arXiv:2604.14918 Abstract Recent advances in the field of active soft matter promise a lot. Both, experimental advances and theoretical understanding point towards new material classes in reach, for example self-healing materials that might switch their properties from elastic to solid
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16.04.2026

Targeting Interleukin-8-Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

Authors Fell J, Pavez-Giani M, Koitka F, Kensah G, Santos GL, van der Vorst EPC, Lenz C, Salinas G, Busley AV, Fedorenko A, Hindmarsh R, Wolf CM, Lutz S, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal Circulation Citation Circulation. 2026 Apr 16. Abstract Background: Genetic variants in components
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09.04.2026

Models of the human heart for biomedical research: Opportunities and challenges

Authors Streckfuss-Bömeke K, Zelarayán LC, Schnabel RB, Kränkel N, Maack C, Eschenhagen T, Kappler HE, Klingmüller U, Kramann R, Loewe A, Milting H, Molina CE, Panáková D, Podesser BK, Schnieke A, Schröder K, Seidel T, Sossalla S, Zgierski-Johnston C, Zimmermann WH, Rog-Zielinska EA, Kohl P Journal Physiological Reports Citation Physiol
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09.04.2026

Pathogenic desmin variants impair nuclear integrity and drive atrial cardiomyopathy

Authors Su W, van Wijk SW, Kishore P, Huang M, Sultan D, Wijdeveld LFJM, Huiskes FG, Collinet ACT, Voigt N, Liutkute A, Brands M, Kirby T, van der Palen RL, Kurakula K, Ramos KS, Lenz C, Bajema IM, van Spaendonck-Zwarts KY, Brodehl A, Milting H, van Tintelen JP, Brundel BJJM
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