Organized Protein Assemblies

Authors Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y Journal Neurotoxicology Citation Neurotoxicology. 2021 Jan;82:89-98. Abstract We have previously shown that JM-20, a new chemical entity consisting of 1,5-benzodiazepine fused to a

Authors Filippou PS, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2020 Dec 21. Abstract Cancer and neurodegeneration are two major leading causes of morbidity and death worldwide. At first sight, the two fields do not seem to share much in common and, if anything, might be placed on opposite

Authors Wittmeier A, Cassini C, Töpperwien M, Denz M, Hagemann J, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Rad (2021) 28. Abstract X-rays are emerging as a complementary probe to visible-light photons and electrons for imaging biological cells. By exploiting their small wavelength

Authors Kraxner J, Lorenz C, Menzel J, Parfentev I, Silbern I, Denz M, Urlaub H, Schwappach B, Köster S Journal Nanoscale Citation Nanoscale. 2020 Dec 22. Abstract The mechanical properties of biological cells are determined by the cytoskeleton, a composite biopolymer network consisting of microtubules, actin filaments and intermediate filaments

Authors Outeiro TF Journal Journal of Neurochemistry Citation J Neurochem. 2020 Dec 9. Abstract Many different types of protein aggregates have attracted the minds and curiosity of countless armies of scientists, i.e., laboratories, in the world for more than 100 years. For example, it was in 1912 that F. Lewy

Authors Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanovic D, Rizzoli S, Köster S Journal Scientific Reports Citation Sci Rep 10, 21086 (2020). Abstract Protein dynamics in the synaptic bouton are still not well understood, despite many quantitative studies of synaptic structure and function. The complexity of the synaptic

Authors Meinhardt J, Radke J, Dittmayer C, Mothes R, Franz J, Laue M, Schneider J, Brünink S, Hassan O, Stenzel W, Windgassen M, Rößler L, Goebel HH, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Heppner BI, Stadelmann

Authors Denz M, Marschall M, Herrmann H, Köster S Journal Soft Matter Citation Soft Matter. 2020 Nov 25. Abstract Vimentin intermediate filaments, together with actin filaments and microtubules, constitute the cytoskeleton in cells of mesenchymal origin. The mechanical properties of the filaments themselves are encoded in their molecular architecture and

Authors Outeiro TF, Heutink P, Bezard E, Cenci AM Journal Movement Disorders Citation Mov Disord. 2020 Nov 16. Abstract Parkinson’s disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely

Authors Dominguez-Meijide A, Vasili E, Outeiro TF Journal Brain Science Citation Brain Sci. 2020 Nov 13;10(11):E858. Abstract Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain.