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15.01.2025

Phenotypes linked to duplication upstream of SOX9: New insights into presentation and diagnosis

Authors Unal E, Tekmenuray-Unal A, Cayir A, Papatya Cakir ED, Beyazit N, Kolbasi B, Gurpinar Tosun B, Yigit G, Zibat A, Wollnik B, Demirbilek H, Guran T Journal The Journal of Clinical Endocrinology and Metabolism Citation J Clin Endocrinol Metab. 2025 Jan 15:dgaf020. Abstract Context: Duplications occurring upstream of the
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14.01.2025

Single neuron diversity supports area functional specialization along the visual cortical pathways

Authors Feyerabend M, Pommer S, Jimenez-Sosa MS, Rachel J, Sunstrum JK, Preuss F, Mestern S, Hinkel R, Mietsch M, Viyajraghavan S, Everling S, Treue S, Arnsten AFT, Lewis DA, Wolf F, Murray J, Muller L, McCarroll S, Krienen F, Datta D, Jing Wang X, Tripathy S, Gonzalez-Burgos G, Inoue W,
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10.01.2025

Super-resolution optical fluctuation imaging

Authors Basak S, Chizhik A, Gallea JI, Gligonov I, Gregor I, Nevskyi O, Radmacher N, Tsukanov R, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2025) Abstract We present a comprehensive review of super-resolution optical fluctuation imaging (SOFI), a robust technique that leverages temporal fluctuations in fluorescence intensity to achieve
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09.01.2025

Cardiovascular MRI-derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis

Authors Lange T, Beuthner BE, Schulz A, Backhaus SJ, Evertz R, Rigorth KR, Toischer K, Kowallick JT, Hasenfuss G, Puls M, Schuster A Journal Radiology: Cardiothoracic Imaging Citation Radiol Cardiothorac Imaging. 2025 Feb;7(1):e230380. Abstract Purpose: To assess the prognostic implications of cardiac MRI-derived imaging markers in individuals with severe aortic
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06.01.2025

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

Authors Hehlert P, Effertz T, Gu RX, Nadrowski B, Geurten BRH, Beutner D, de Groot BL, Göpfert MC Journal Nature Neuroscience Citation Nat Neurosci. 2025 Jan 6. Abstract The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have
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02.01.2025

Molecular basis of human nuclear and mitochondrial tRNA 3′-processing

Authors Bhatta A, Kuhle B, Yu RD, Spanaus L, Ditter K, Bohnsack KE, Hillen H Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2025). Abstract Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3′ end processing of
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02.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Griesinger C, Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot B, Andreas L Journal Nature Communications Citation Nat Commun 2025. accepted manuscript. Abstract Aggregation intermediates play a pivotal role in
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31.12.2024

A microscopy-based screen identifies cellular kinases modulating mitochondrial translation

Authors Yousefi R, Cruz-Zaragoza LD, Valpadashi A, Hansohn C, Dahal D, Richter-Dennerlein R, Rizzoli S, Urlaub H, Rehling P, Pacheu-Grau D Journal Cell Reports Citation Cell Rep, 44, 115143. Abstract Mitochondrial DNA encodes 13 subunits of the oxidative phosphorylation (OXPHOS) system, which are synthesized inside the organelle and essential for
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30.12.2024

Sparse chaos in cortical circuits

Authors Engelken R, Monteforte M, Wolf F   Journal Arxiv   Citation arXiv:2412.21188.   Abstract Nerve impulses, the currency of information flow in the brain, are generated by an instability of the neuronal membrane potential dynamics. Neuronal circuits exhibit collective chaos that appears essential for learning, memory, sensory processing, and
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25.12.2024

Cognitive decline and neuroinflammation in a mouse model of obesity: An accelerating role of ageing

Authors Rajput M, Malik IA, Methi A, Cortés Silva JA, Fey D, Wirths O, Fischer A, Wilting J, von Arnim CAF Journal Brain, Behavior, and Immunity Citation Brain Behav Immun. 2024 Dec 25:S0889-1591(24)00883-3. Abstract Obesity, a pandemic, worldwide afflicts almost one billion people. Obesity and ageing share several pathological pathways
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