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18.04.2026

The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP

Authors Rout SR, Kulke M, Droemer M, Wendel M, Cheng TC, Mauck TA, Asgari S, Nemec AA, Shein M, Sato Y, Fukai S, Witte G, Tomko Jr. RJ, Stengel F, Zacharias M, Schuetz AK, Sakata E Journal BioRxiv Citation bioRxiv 2026.04.16.718620 Abstract The multifunctional AAA+ ATPase p97/VCP is a pivotal
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16.04.2026

Distributional Convergence of Empirical Entropic Optimal Transport and Statistical Applications

Authors Arenas-Velilla S, Munk A, Rodríguez LA Journal Arxiv Citation arXiv:2604.12940 Abstract Recently, the statistical properties of empirical Entropic Optimal Transport (EOT) have attracted great interest, as this quantity has been shown to be useful for complex data analysis, among other reasons due to its computational efficiency. In several applications,
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16.04.2026

Self-propelled particles driven by light

Authors Fischer J, Jurado A, Betz T Journal Arxiv Citation arXiv:2604.14918 Abstract Recent advances in the field of active soft matter promise a lot. Both, experimental advances and theoretical understanding point towards new material classes in reach, for example self-healing materials that might switch their properties from elastic to solid
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09.04.2026

Models of the human heart for biomedical research: Opportunities and challenges

Authors Streckfuss-Bömeke K, Zelarayán LC, Schnabel RB, Kränkel N, Maack C, Eschenhagen T, Kappler HE, Klingmüller U, Kramann R, Loewe A, Milting H, Molina CE, Panáková D, Podesser BK, Schnieke A, Schröder K, Seidel T, Sossalla S, Zgierski-Johnston C, Zimmermann WH, Rog-Zielinska EA, Kohl P Journal Physiological Reports Citation Physiol
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09.04.2026

Pathogenic desmin variants impair nuclear integrity and drive atrial cardiomyopathy

Authors Su W, van Wijk SW, Kishore P, Huang M, Sultan D, Wijdeveld LFJM, Huiskes FG, Collinet ACT, Voigt N, Liutkute A, Brands M, Kirby T, van der Palen RL, Kurakula K, Ramos KS, Lenz C, Bajema IM, van Spaendonck-Zwarts KY, Brodehl A, Milting H, van Tintelen JP, Brundel BJJM
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09.04.2026

In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation

Authors Du D, Albert L, Weitzel M, Eijsink LE, Cotroneo ER, Marzin D, Opazo F, Simeth NA Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2026 Apr 9:e6231674. Abstract Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts
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07.04.2026

Modeling spatial contrast sensitivity in responses of primate retinal ganglion cells to natural movies

Authors Sridhar S, Vystrčilová M, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Ecker AS, Gollisch T Journal PLoS Computational Biology Citation PLoS Comput Biol. 2026 Apr 7;22(4):e1014157. Abstract Retinal ganglion cells, the output neurons of the vertebrate retina, often display nonlinear summation of
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02.04.2026

Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients

Authors Liutkute A, Berrandou TE, Kestel S, Schnelle M, Dschun O, Amedei HA, Neuenroth L, Rytkin E, Kyshynska O, Kensah G, El-Essawi A, Jebran AF, Danner BC, Baraki H, Kutschka I, Bremmer F, Urlaub H, Schmidt C, Bouatia-Naji N, Efimov IR, Brundel BJJM, Lenz C, Voigt N Journal Cardiovascular Research
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02.04.2026

Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis

Authors Azmain T, Tran DDH, Saifuddin AB, Xu X, Alnour F, Hasenfuß G, Hulshoff M, Eckhardt PL, Tan X, Zeisberg M, Hille SS, Müller OJ, Zeisberg EM Journal Cardiovascular Research Citation Cardiovasc Res. 2026 Apr 2:cvag050. Abstract Aims: Cardiac fibrosis remains a significant and currently untreatable contributor to mortality in
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31.03.2026

Keratin Cortex Stabilizes Cells and Cell-Cell Contacts at High Strains

Authors Meyer R, Unkelbach U, Jain P, Rölleke U, Schwarz N, Perez-Tirado A, Schepers AV, Geisler C, Janshoff A, Köster S Journal PRX Life Citation PRX Life 4, 013038. Abstract The eukaryotic cytoskeleton consists of three filament types: actin filaments, microtubules, and intermediate filaments (IFs). IF proteins are expressed in
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