Research Alliance

Authors Fuchs U, Schroeder S, Pena T, Krueger DM, Burkhardt S, Schuetz AL, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736437. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of cellular identity and disease associated gene expression programs, yet their role in astrocyte reactivity remains poorly understood.

Authors Requardt R, Li H Journal Arxiv Citation arXiv:2607.03088 Abstract In many modern experiments, latent interactions drive multicomponent stochastic systems, yet the data are available only as pooled measurements that obscure these dependencies. Whether such interactions can be identified and inferred from aggregate signals remains largely unexplored. Motivated by multi-channel

Authors Fuchs U, Schroeder S, Pena t, Krueger DM, Burkhardt S, Schuetz AL, Hempel N, Gisa V, Taghavi T, Cortes J, Gertig M, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736275. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their

Authors Chanda S, Rizzoli SO, Shaib AH Journal Bioconjugate Chemistry Citation Bioconjug Chem. 2026 Jul 1. Abstract Artificial intelligence is becoming a transformative tool in life sciences, not just by improving the results of existing technologies but also by introducing fundamental new ways of discovery. Initially applied to denoising, segmentation,

Authors da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez D, Klein R, Giese A, Griesinger C, Dudanova I Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2026 Jun 26. Abstract Huntington’s disease (HD) is a hereditary movement disorder caused by a CAG repeat expansion in

Authors Benitez-Fuente F, Collado J, Morello-Lopez J, Pagano-Marquez R, Ruiz-Lopez N, Keller J, Botella MA, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2026.06.23.733366. Abstract Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma membrane (PM) enable direct intermembrane exchange of signals and metabolites. The Extended Synaptotagmins (E-Syts) are

Authors Jenkins B, Frank T Journal BioRxiv Citation bioRxiv 2026.06.17.732810. Abstract Chemical cues guide essential behaviors by signaling food, danger, and social information. A major dimension of chemosensory processing is valence, which biases animals toward approach or avoidance, yet its brain-wide organization in vertebrates remains unclear. Here, we used larval

Authors Laurence SD, Schilling M, Grimm NA, Mace E, Bemme S, Pape C Journal MedRxiv Citation medRxiv 2026.06.16.26355668. Abstract Purpose: New therapeutic strategies such as optogenetics have created a need for accurate tracking of inner retina degeneration in Retinitis pigmentosa (RP) patients. We introduce two tailored deep learning models to

Authors Ignatyeva N, Cheruiyot C, Saleem HN, Wali R, Plota D, Zhang W, Schön S, Brandenburg S, Yang Z, Steyer A, Urlaub H, Rasmussen T, Mogensen J, Pronto JRD, Döring Y, Radke MH, Shcherbata H, Lehnart SE, Janshoff A, Sossalla S, Ruhwedel T, Moebius W, Toischer K, Brügger B, Haucke

Authors Merghani M, Gerhardt E, Hesse M, Fahlbusch C, Boecker CA, Outeiro TF Journal BioRxiv Citation bioRxiv 2026.06.12.731951. Abstract Mutations in the LRRK2 gene are the most common genetic cause of both familial and sporadic Parkinson’s disease (PD). LRRK2 belongs to the leucine-rich repeat kinase (LRRK) family. Two members of