Organized Protein Assemblies

Home >> Publications >> Research Alliance >> Organized Protein Assemblies >> Page 4
Feature image not available
24.02.2021

Emerging concepts in synucleinopathies

Authors Outeiro TF Journal Acta Neuropathologica (Editorial) Citation Acta Neuropathol. 2021 Feb 24. Abstract No abstract available DOI 10.1007/s00401-021-02290-7 Pubmed Link  
Learn More
Feature image not available
12.02.2021

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Authors Brás IC, Outeiro TF Journal Cells Citation Cells 2021, 10(2), 375. Abstract The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis. The stereotypical distribution and evolution of the pathology during disease is often attributed to the cell-to-cell
Learn More
Feature image not available
05.02.2021

Two mechanisms drive pronuclear migration in mouse zygotes

Authors Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M Journal Nature Communications Citation Nat Commun 12, 841 (2021). Abstract A new life begins with the unification of the maternal and paternal chromosomes upon fertilization. The parental chromosomes first become enclosed in two separate pronuclei
Learn More
Feature image not available
02.02.2021

Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy

Authors Oliveira da Silva MI , Santejo M, Babcock IW, Magalhães A, Minamide LS, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Bamburg JR, Liz MA Journal BioRxiv Citation bioRxiv 2021.02.02.425931. Abstract Cognitive dysfunction and dementia are presently recognized as major complications in α-synucleinopathies, namely in Dementia with
Learn More
Feature image not available
30.01.2021

Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders

Authors Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I Journal Acta Neuropathologica Citation Acta Neuropathol. 2021 Jan 30. Abstract Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as Parkinson’s disease (PD), Parkinson’s
Learn More
Feature image not available
25.01.2021

Exploring early time points of vimentin assembly in flow by fluorescence fluctuation spectroscopy

Authors Perego E, Köster S Journal Lab on a Chip Citation Lab Chip. 2021 Jan 25. Abstract Despite the importance for cellular processes, the dynamics of molecular assembly, especially on fast time scales, is not yet fully understood. To this end, we present a multi-layer microfluidic device and combine it
Learn More
Feature image not available
15.01.2021

Aneuploidy in human eggs: contributions of the meiotic spindle

Authors Thomas C, Cavazza T, Schuh M Journal Biochemical Society Transactions Citation Biochem Soc Trans. 2021 Jan 15:BST20200043. Abstract Human eggs frequently contain an incorrect number of chromosomes, a condition termed aneuploidy. Aneuploidy affects ∼10–25% of eggs in women in their early 30s, and more than 50% of eggs from
Learn More
Feature image not available
14.01.2021

Phase Separation during Germline Development

Authors So C, Cheng S, Schuh M Journal Trends in Cell Biology Citation Trends in Cell Biology, Jan 2021, online. Abstract Phase separation has emerged as a new key principle of intracellular organization. Phase-separated structures play diverse roles in various biological processes and pathogenesis of protein aggregation diseases. Recent work
Learn More
Feature image not available
08.01.2021

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Authors Dominguez-Meijide A, Parrales V, Vasili E, González-Lizárraga F, König A, Lázaro DF, Lannuzel A, Haik S, Del Bel E, Chehín R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF Journal Neurobiology of Disease Citation Neurobiol Dis. 2021 Jan 8;151:105256. Abstract Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)
Learn More
Feature image not available
07.01.2021

Alpha-Synuclein Antibody Characterization: Why Semantics Matters

Authors Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2021 Jan 7. Abstract In protein aggregation disorders, we assume that, during the process of protein aggregation, different types of aggregated species (oligomers, protofibrils, fibrils, etc.) are formed, some of which can be toxic to cells/tissues/organs. Recent evidence from numerous studies
Learn More
X

Open Positions

EN DE
X
X