Organized Protein Assemblies

Authors Komorowski K, Schaeper J, Sztucki M, Sharpnack L, Brehm G, Köster S, Salditt T Journal Soft Matter Citation Soft Matter. 2020 May 6;16(17):4142-4154. Abstract We have used time-resolved small-angle X-ray scattering (SAXS) to study the adhesion of lipid vesicles in the electrostatic strong-coupling regime induced by divalent ions. The

Authors Robisch AL, Eckermann M, Topperwien M, van der Meer F, Stadelmann C, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham) 2020 Jan;7(1). Abstract X-ray cone-beam holotomography of unstained tissue from the human central nervous system reveals details down to subcellular length scales. This visualization of

Authors Töpperwien M, van der Meer F, Stadelmann-Nessler C, Salditt T Journal NeuroImage Citation Neuroimage 2020 Apr 15;210:116523. Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder which is characterized by increasing dementia. It isaccompanied by the development of extracellularβ-amyloid plaques and neurofibrillary tangles in the gray matterof the brain. Histology

Authors Maurer A, Leonov A, Ryazanov S, Herfert K, Kuebler L, Buss S, Schmidt F, Weckbecker D, Linder R, Bender D, Giese A, Pichler BJ, Griesinger C Journal ChemMedChem Citation ChemMedChem. 2020 Mar 5;15(5):411-415. Abstract There is an urgent clinical need for imaging of alpha-synuclein (alphaSyn) fibrils, the hallmark biomarker

Authors Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, Winter R, Khemtemourian L, Griesinger C, Killian JA Journal Scientific Reports Citation Sci Rep. 2019 Dec 13;9(1):19023. Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species.

Authors Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gartner A, Kugler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF Journal Science Advances Citation Sci Adv. 2019 Dec 18;5(12):eaay2670. Abstract The cellular and the molecular mechanisms by which long noncoding RNAs

Authors Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF Journal Nature Protocols Citation Nat Protoc. 2019 Dec;14(12):3333-3365. Abstract Proteins are continually produced and degraded, to avoid the accumulation of old or damaged molecules and to maintain the efficiency of physiological processes. Despite its importance, protein turnover

Authors Brendel M, Deussing M, Blume T, Kaiser L, Probst F, Overhoff F, Peters F, von Ungern-Sternberg B, Ryazanov S, Leonov A, Griesinger C, Zwergal A, Levin J, Bartenstein P, Yakushev I, Cumming, P, Boening G, Ziegler S, Herms J, Giese A, Rominger A Journal Alzheimers’s Research and Therapy Citation

Authors Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N Journal Movement Disorders Citation Mov Disord. 2019 Feb;34(2):255-263. Abstract BACKGROUND: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of alpha-synuclein