Calcium-Triggered Membrane Fusion

Authors Wegner W, Steffens H, Gregor C, Wolf F, Willig KI Journal Elife Citation eLife 2022;11:e73603. Abstract Synaptic plasticity underlies long-lasting structural and functional changes to brain circuitry and its experience-dependent remodeling can be fundamentally enhanced by environmental enrichment. It is however unknown, whether and how the environmental enrichment alters

Authors Grabner CP, Moser T Journal Elife Citation Elife. 2021 Oct 7;10:e63844. Abstract Rod photoreceptors (PRs) use ribbon synapses to transmit visual information. To signal ‘no light detected’ they release glutamate continually to activate post-synaptic receptors. When light is detected glutamate release pauses. How a rod’s individual ribbon enables this

Authors Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK Journal Physiological Reports Citation Physiol Rep. 2021 Sep;9(18):e15030. Abstract Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is an inherited arrhythmogenic disorder caused by missense mutations in the cardiac ryanodine receptors (RyR2), that result in increased β-adrenoceptor stimulation-induced

Authors Teiwes NK, Mey I, Baumann PC, Strieker L, Unkelbach U, Steinem C Journal ACS Applied Materials & Interfaces Citation ACS Appl Mater Interfaces. 2021 Jun 9;13(22):25805-25812. Abstract Giant plasma membrane vesicles (GPMVs) are a highly promising model system for the eukaryotic plasma membrane. The unresolved challenge, however, is a

Authors Antonschmidt L, Dervişoğlu R, Sant V, Movellan KT, Mey I, Riedel D, Steinem C, Becker S, Andreas LB, Griesinger C Journal Science Advances Citation Sci Adv. 2021 May 14;7(20):eabg2174. Abstract Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structures, yet little is

Authors Neher E, Taschenberger H Journal Neuroscience Citation Neuroscience. 2021 Mar 15;458:182-202. Abstract Synaptic vesicles (SVs) undergo multiple steps of functional maturation (priming) before being fusion competent. We present an analysis technique, which decomposes the time course of quantal release during repetitive stimulation as a sum of contributions of SVs,

Authors Pofantis E, Neher E, Dresbach T Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2022551118. Abstract Neurotransmitter release occurs by regulated exocytosis from synaptic vesicles (SVs). Evolutionarily conserved proteins mediate the essential aspects of this process, including the membrane

Authors Cheret C, Ganzella M, Preobraschenski J, Jahn R, Ahnert-Hilger G Journal Cell Reports Citation Cell Rep. 2021 Jan 12;34(2):108623. Abstract Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate. VGLUTs were originally identified as sodium-dependent transporters of inorganic phosphate (Pi), but the physiological relevance of this activity remains unclear.

Authors Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK Journal Elife Citation Elife. 2020 Nov 9;9:e62506. Abstract Insulin

Authors Dieter A, Keppeler D, Moser T Journal Cell Reports Citation EMBO Mol Med 2020 Apr 7;12(4):e11618. Abstract Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss. By electrically stimulating the