Calcium-Triggered Membrane Fusion

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29.11.2023

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Authors Jaime Tobón LM, Moser T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. Abstract In our hearing organ, sound is encoded at ribbon synapses formed by inner hair cells (IHCs) and spiral
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24.10.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J. Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2305460120. Abstract Pre- and postsynaptic forms of long-term potentiation
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17.10.2023

CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells

Authors Oestreicher D, Chepurwar S, Kusch K, Rankovic V, Jung S, Strenzke N, Pangrsic T Journal BioRxiv Citation bioRxiv 2023.10.16.562475 Abstract To encode continuous sound stimuli, the inner hair cell (IHC) ribbon synapses utilize calcium-binding proteins (CaBPs), which reduce the inactivation of their CaV1.3 calcium channels. Mutations in the CABP2
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14.04.2023

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Authors Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann
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19.01.2023

Graded optogenetic activation of the auditory pathway for hearing restoration

Authors Mittring A, Moser T, Huet AT Journal Brain Stimulation Citation Brain Stimul. 2023 Jan 23:S1935-861X(23)01673-X. Abstract Optogenetic control of neural activity enables innovative approaches to improve functional restoration of diseased sensory and motor systems. For clinical translation to succeed, optogenetic stimulation needs to closely match the coding properties of
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23.12.2022

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

Authors Chakrabarti R, Jaime Tobón LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C Journal elife Citation Elife. 2022 Dec 23;11:e79494. Abstract RRibbon synapses of cochlear inner hair cells (IHCs)
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25.10.2022

Cochlear Hair Cell Innervation is Dependent on a Modulatory Function of Semaphorin-3A

Authors Cantu-Guerra HL, Papazian MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM Journal Developmental Dynamics Citation Dev Dyn. 2022 Oct 25. Abstract Background: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is
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20.10.2022

Bridging the gap between presynaptic hair cell function and neural sound encoding

Authors Jaime Tobón LM, Moser T Journal BioRxiv Citation bioRxiv 2022.10.19.512823. Abstract Neural diversity can expand the encoding capacity of a circuitry. A striking example of diverse structure and function is presented by the afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea. Synapses
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06.09.2022

Tackling the Dynamic Range Problem of Hearing: Diverse Hair Cell Synapses Enable Broad Neural Sound Intensity Coding

Authors Jaime Tobón LM, Moser T Journal Cell Reports Citation Cell Rep, 2022. under review. Abstract Synaptic heterogeneity can expand the encoding capacity of individual neurons or sensory cells. The afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea exhibit marked heterogeneity in structure
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09.08.2022

IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Authors Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. Abstract Regulation
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