Calcium-Triggered Membrane Fusion

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Graded optogenetic activation of the auditory pathway for hearing restoration

Authors Mittring A, Moser T, Huet AT Journal Brain Stimulation Citation Brain Stimul. 2023 Jan 23:S1935-861X(23)01673-X. Abstract Optogenetic control of neural activity enables innovative approaches to improve functional restoration of diseased sensory and motor systems. For clinical translation to succeed, optogenetic stimulation needs to closely match the coding properties of
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Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

Authors Chakrabarti R, Jaime Tobón LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C Journal elife Citation Elife. 2022 Dec 23;11:e79494. Abstract RRibbon synapses of cochlear inner hair cells (IHCs)
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Cochlear Hair Cell Innervation is Dependent on a Modulatory Function of Semaphorin-3A

Authors Cantu-Guerra HL, Papazian MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM Journal Developmental Dynamics Citation Dev Dyn. 2022 Oct 25. Abstract Background: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is
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Bridging the gap between presynaptic hair cell function and neural sound encoding

Authors Jaime Tobón LM, Moser T Journal BioRxiv Citation bioRxiv 2022.10.19.512823. Abstract Neural diversity can expand the encoding capacity of a circuitry. A striking example of diverse structure and function is presented by the afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea. Synapses
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Tackling the Dynamic Range Problem of Hearing: Diverse Hair Cell Synapses Enable Broad Neural Sound Intensity Coding

Authors Jaime Tobón LM, Moser T Journal Cell Reports Citation Cell Rep, 2022. under review. Abstract Synaptic heterogeneity can expand the encoding capacity of individual neurons or sensory cells. The afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea exhibit marked heterogeneity in structure
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IGF-1 receptor regulates upward firing rate homeostasis via the mitochondrial calcium uniporter

Authors Katsenelson M, Shapira I, Abbas E, Jevdokimenko K, Styr B, Ruggiero A, Aïd S, Fornasiero EF, Holzenberger M, Rizzoli SO, Slutsky I Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2121040119. Abstract Regulation
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Is there an unmet medical need for improved hearing restoration?

Authors Wolf BJ, Kusch K, Hunniford V, Vona B, Kühler R, Keppeler D, Strenzke N, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2022 Jul 14:e15798. Abstract Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for
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A Sequential Two-Step Priming Scheme Reproduces Diversity in Synaptic Strength and Short-Term Plasticity

Authors Lin KH, Taschenberger H, Neher E Journal Proceedings of the National Academy of Sciences Citation Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2207987119. Abstract Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional
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Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants

Authors Khurana L, Keppeler D, Jablonski L, Moser T Journal Computational and Structural Biotechnology Journal Citation Comput Struct Biotechn J, 2022. Abstract When hearing fails, electrical cochlear implants (eCIs) partially restore hearing by direct stimulation of spiral ganglion neurons (SGNs). As light can be better confined in space than electrical
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Retinal Encoding of Natural Scenes

Authors Karamanlis D, Schreyer HM, Gollisch T Journal Annual Review of Vision Science Citation Annu Rev Vis Sci. 2022 Jun 8. Abstract An ultimate goal in retina science is to understand how the neural circuit of the retina processes natural visual scenes. Yet most studies in laboratories have long been
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