2025

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15.04.2025

Synchronization in epithelial tissue morphogenesis

Authors Richa P, Häring M, Wang Q, Choudhury AR, Göpfert MC, Wolf F, Großhans J, Kong D Journal Current Biology Citation Curr Biol. 2025 Apr 11:S0960-9822(25)00382-3. Abstract Coordination of cell behavior is central to morphogenesis, when arrays of cells simultaneously undergo shape changes or dynamic rearrangements. In epithelia, cell shape
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15.04.2025

D-amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection.

Authors Maurer W, Zieseniss A, Priya VP, Chen Y, Bauer L, Hillemann A, Rehling P, Nanadikar MS, de Zélicourt D, Kurtcuoglu V, Katschinski DM Journal British Journal of Pharmacology Citation Br J Pharmacol. 2025 Apr 15. Abstract Background and purpose: D-amino acid oxidase (DAO) has been developed as a chemogenetic
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15.04.2025

Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Authors Vystrčilová M, Sridhar S, Burg MF, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Gollisch T,Ecker AS Journal BioRxiv Citation bioRxiv 2025.04.09.647910. Abstract The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, or motion. However, it
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14.04.2025

Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study

Authors Galbusera R, Weigel M, Bahn E, Schaedelin S, Cagol A, Lu PJ, Barakovic M, Melie-Garcia L, Franz J, Dechent P, Nair G, Kappos L, Brück W, Stadelmann C, Granziera C Journal Brain Pathology Citation Brain Pathol. 2025 Apr 14:e70010. Abstract Remyelination of cortical lesions in people with multiple sclerosis
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13.04.2025

Differentiation of Mature Dopaminergic Neurons from Human Induced Pluripotent Stem Cells

Authors Garg P, Bähr M, Kügler S Journal Methods in Molecular Biology (Clifton, N.J.) Citation Methods Mol Biol. 2025;2910:53-68. Abstract Reprogramming of somatic cells like blood cells and fibroblasts to obtain human induced pluripotent stem cells (hiPSCs) has become a state-of-the-art tool to study human diseases. The self-renewable hiPSCs offer
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11.04.2025

A role for astrocytic miR-129-5p in frontotemporal dementia

Authors Kaurani L, Pradhan R, Schröder S, Burkhardt S, Schuetz AL, Krüger DM, Pena T, Heutink P, Sananbenesi F, Fischer A Journal Translational Psychiatry Citation Transl Psychiatry. 2025 Apr 11;15(1):142. Abstract Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language
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11.04.2025

Distinct transmission sites within a synapse for strengthening and homeostasis

Authors Yang Y, Wong MH, Huang X, Chiu DN, Liu YZ, Prabakaran V, Imran A, Panzeri E, Chen Y, Huguet P, Kunisky A, Ho J, Dong Y, Carter BC, Xu W, Schlüter OM Journal Science Advances Citation Sci Adv. 2025 Apr 11;11(15):eads5750. Abstract At synapses, miniature synaptic transmission forms the
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08.04.2025

Stamped counting for biomedical images

Authors Jeremias J, Pape C Journal Methods in Microscopy Citation Methods in Microscopy, 2025. Abstract Counting objects is an important task in biomedical image analysis, for example to count cells in microscopy or microbial colonies in laboratory applications. Similar to most image analysis tasks, modern approaches to counting rely on
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08.04.2025

Understanding inherited cardiomyopathies: clinical aspects and genetic determinants

Authors Yigit G, Kaulfuß S, Wollnik B Journal Medizinische Genetik Citation Med Genet. 2025 Apr 8;37(2):103-111. Abstract Cardiomyopathies (CMs) are a clinically heterogeneous group of cardiovascular diseases characterized by structural and functional abnormalities of the heart muscle in the absence of coronary artery disease, hypertension, valve disease, or congenital heart
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07.04.2025

Modulation of protein activity by small RNA base pairing internal to coding sequences

Authors Thongdee N, Alaniz MM, Samatova E, Zhong A, Esnault C, Zhang H, Dale RK, Rodnina MV, Storz G Journal Molecular Cell Citation Mol Cell. 2025 Mar 30:S1097-2765(25)00258-8. Abstract Most characterized interactions between bacterial small RNAs (sRNAs) and their target mRNAs occur near ribosome binding sites, resulting in changes in
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