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23.04.2025

Synaptophysin accelerates synaptic vesicle fusion by expanding the membrane upon neurotransmitter loading

Authors Preobraschenski J, Kreutzberger AJB, Ganzella M, MĂĽnster-Wandowski A, Kreutzberger MAB, Oolsthorn LHM, Seibert S, Kiessling V, Riedel D, Witkowska A, Ahnert-Hilger G, Tamm LK, Jahn R Journal Science Advances Citation Sci Adv. 2025 Apr 25;11(17):eads4661. Abstract Synaptic transmission is mediated by the exocytotic release of neurotransmitters stored in synaptic
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23.04.2025

Integrative analysis of miRNA expression profiles reveals distinct and common molecular mechanisms underlying broad diagnostic groups of severe mental disorders

Authors Solomon P, Kaurani L, Budde M, Guiné JB, Krüger DM, Riquin K, Pena T, Burkhardt S, Fourgeux C, Adorjan K, Heilbronner M, Kalman JL, Kohshour MO, Papiol S, Reich-Erkelenz D, Schaupp SK, Schulte EC, Senner F, Vogl T, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter
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22.04.2025

BTRR complex deficiency is a driver for genomic instability in Bloom syndrome

Authors Gönenc II, Wolff A, Busley AV, Wieland A, Tijhuis A, Müller C, Wardenaar R, Argyriou L, Kaulfuß S, Räschle M, Spierings DCJ, Foijer F, Bastians H, Yigit G, Zibat A, Cyganek L, Wollnik B Journal BioRxiv Citation bioRxiv 2025.04.17.649287. Abstract Biallelic loss-of-function (LoF) variants in the BTRR complex members
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22.04.2025

Structural insight into binding of novel PET tracer MODAG-005 to lipidic 𝛼-Synuclein fibrils

Authors Kim M, Matthes D, Frieg B, Leonov A, Ryazanov S, Bleher D,Grotegerd AK, Dienemann C, Giese A, Schröder GF, Becker S, Herfert K, de Groot BL, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.04.21.649837. Abstract Accumulation of α-synuclein (αSyn) aggregates in the human brain is the major hallmark
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18.04.2025

Proteorhodopsin insights into the molecular mechanism of vectorial proton transport

Authors Bukhdruker S, Gushchin I, Shevchenko V, Kovalev K, Polovinkin V, Tsybrov F, Astashkin R, Alekseev A, Mikhaylov A, Bukhalovich S, Bratanov D, Ryzhykau Y, Kuklina D, Caramello N, Rokitskaya T, Antonenko Y, Rulev M, Stoev C, Zabelskii D, Round E, Rogachev A, Borshchevskiy V, Ghai R, Bourenkov G, Zeghouf
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17.04.2025

Coupling of ribosome biogenesis and translation initiation in human mitochondria

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we
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15.04.2025

Synchronization in epithelial tissue morphogenesis

Authors Richa P, Häring M, Wang Q, Choudhury AR, Göpfert MC, Wolf F, Großhans J, Kong D Journal Current Biology Citation Curr Biol. 2025 Apr 11:S0960-9822(25)00382-3. Abstract Coordination of cell behavior is central to morphogenesis, when arrays of cells simultaneously undergo shape changes or dynamic rearrangements. In epithelia, cell shape
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15.04.2025

D-amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection.

Authors Maurer W, Zieseniss A, Priya VP, Chen Y, Bauer L, Hillemann A, Rehling P, Nanadikar MS, de Zélicourt D, Kurtcuoglu V, Katschinski DM Journal British Journal of Pharmacology Citation Br J Pharmacol. 2025 Apr 15. Abstract Background and purpose: D-amino acid oxidase (DAO) has been developed as a chemogenetic
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15.04.2025

Spatial Adaptation of Primate Retinal Ganglion Cells between Artificial and Natural Stimuli

Authors Vystrčilová M, Sridhar S, Burg MF, Khani MH, Karamanlis D, Schreyer HM, Ramakrishna V, Krüppel S, Zapp SJ, Mietsch M, Gollisch T,Ecker AS Journal BioRxiv Citation bioRxiv 2025.04.09.647910. Abstract The retina encodes a broad range of stimuli, adapting its computations to features like brightness, contrast, or motion. However, it
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14.04.2025

Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study

Authors Galbusera R, Weigel M, Bahn E, Schaedelin S, Cagol A, Lu PJ, Barakovic M, Melie-Garcia L, Franz J, Dechent P, Nair G, Kappos L, BrĂĽck W, Stadelmann C, Granziera C Journal Brain Pathology Citation Brain Pathol. 2025 Apr 14:e70010. Abstract Remyelination of cortical lesions in people with multiple sclerosis
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