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29.11.2023

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Authors Jaime Tobón LM, Moser T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. Abstract In our hearing organ, sound is encoded at ribbon synapses formed by inner hair cells (IHCs) and spiral
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28.11.2023

Structure and dynamics of human cardiac fibroblast nanotubes

Authors Schmid-Herbstritt SC, Stief G, Greiner J, Felekary A, Madl J, Zeidler V, Heer J, Iaconianni P, Koch M, Kollmar K, Walz C, Nubling S, Kok T, Pronto JR, Kutschka I, Voigt N, Morgan G, Dienert J, Brox T, Briquez P, Peyronnet R, Rohrbach A, Kohl P, Rog-Zielinska EA Journal
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27.11.2023

Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina

Authors Krueppel S, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Zapp SJ, Mietsch M, Karamanlis D, Gollisch T Journal BioRxiv Citation bioRxiv 2023.11.27.568854. Abstract Spatially nonlinear stimulus integration by retinal ganglion cells lies at the heart of various computations performed by the retina. It arises from the nonlinear transmission
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21.11.2023

Unraveling haplotype errors in the DFNA33 locus

Authors Vona B, Regele S, Rad A, Strenzke N, Pater JA, Neumann K, Sturm M, Haack TB, Am Zehnhoff-Dinnesen AG Journal Frontiers in Genetics Citation Front. Genet. 14:1214736. Abstract Genetic heterogeneity makes it difficult to identify the causal genes for hearing loss. Studies from previous decades have mapped numerous genetic
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20.11.2023

Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis

Authors Ricagno S, Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernandez-Busnadiego R, Palladini G Journal Research Square Citation Research Square 2023. 20 Nov
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18.11.2023

Efficient and sustained optogenetic control of nervous and cardiac systems

Authors Zerche M, Hunniford V, Alekseev A, El May F, Vavakou A, Siegenthaler D, Hueser MA, Kiehn SM, Garrido-Charles A, Alvanos T, Witzke I, Trenholm S, Macé E, Kusch K, Bruegmann T, Wolf BJ, Mager T, Moser T Journal BioRxiv Citation bioRxiv 2023.11.17.567544. Abstract Optogenetic control of cells is a
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17.11.2023

Prediction mismatch responses arise as corrections of a predictive spiking code

Authors van Driel K, Rudelt L, Priesemann V, Mikulasch FA Journal Biorxiv Citation bioRxiv 2023.11.16.567335. Abstract Prediction mismatch responses in cortex seem to signal the difference between an internal model of the animal and sensory observations. Often these responses are interpreted as evidence for the existence of error neurons, which
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13.11.2023

Tazarotene and Bexarotene Show Efficacy as In Vitro Therapeutic Agents in Multiple Sulfatase Deficiency

Authors Schlotawa l, Matysiak K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T, Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregola J, Pena T, Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French DL, Gelb MH, Gärtner J Journal Neuropediatrics Citation Neuropediatrics 2023; 54(S 01):
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10.11.2023

Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders

Authors Kaiyrzhanov R, Rad A, Lin SJ, Bertoli-Avella A, Kallemeijn WW, Godwin A, Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Ghayoor Karimiani E, Hempel M, Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi JR, Ganieva M, Fowler B, Aanicai R, Akay Tayfun
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06.11.2023

Structure of the transcribing RNA polymerase II-Elongin complex

Authors Chen Y, Kokic G, Dienemann C, Dybkov O, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2023 Nov 6. Abstract Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM
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