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02.07.2024

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Authors Vasili E, Konig A, Al-Azzani M, Bosbach C, Gatzemeier LM, Chegao A, Miranda HV, Erskine D, Outeiro T Journal BioRxiv Citation bioRxiv 2024.06.27.600956. Abstract The risk of developing Parkinson’s disease (PD) is elevated in people with type 2 diabetes, but the precise molecular pathways underlying this connection are still
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02.07.2024

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Authors Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D Journal Melanoma Research Citation Melanoma Res. 2024 Jul 2. Abstract Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically
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27.06.2024

PRDM16-DT is a Brain and Astrocyte-Specific lncRNA Implicated in Alzheimers Disease

Authors Schroeder S, Fuchs U, Gisa V, Pena T, Krueger DM, Hempel N, Burkhardt S, Salinas-Riester G, Schuetz AL, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2024.06.27.600964 Abstract Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of
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25.06.2024

Structural insights into the regulation of RyR1 by S100A1

Authors Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024
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25.06.2024

Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution

Authors de Bruyn E, Dorn AE, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P Journal BioRxiv Citation bioRxiv 2023.03.10.531864. Abstract Serine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a key player in Parkinson’s disease and other synucleinopathies. Here, molecular
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24.06.2024

Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

Authors Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack
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22.06.2024

Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

Authors Outeiro TF, Brocardo PS, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2024 Jun 22. Abstract Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network.
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20.06.2024

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Authors Harasimov K, Gorry RL, Welp LM, Penir SM, Horokhovskyi Y, Cheng S, Takaoka K, Stützer A, Frombach AS, Taylor Tavares AL, Raabe M, Haag S, Saha D, Grewe K, Schipper V, Rizzoli SO, Urlaub H, Liepe J, Schuh M Journal Nature Cell Biology Citation Nat Cell Biol. 2024 Jun
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18.06.2024

Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS

Authors Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt
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13.06.2024

Autonomous bioluminescence emission from transgenic mice

Authors Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C Journal BioRxiv Citation bioRxiv 2024.06.13.598801. Abstract The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here
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