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26.02.2025

Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family

Authors Laurent C, Poncet G, Herskovits T, Alves de Sousa R, Le Corre L, Al-Azzani M, Koenig A, Birman S, Outeiro TF, Mansuy D, Dairou J   Journal ACS Chemical Neuroscience   Citation ACS Chem Neurosci. 2025 Feb 26.   Abstract The protein DJ-1 appears to play a protective role
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25.02.2025

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

Authors Schwenzer N, Tsukanov R, Kohl T, Basak S, Sobitov I, Seibertz F, Kapoor R, Voigt N, Enderlein J, Lehnart SE   Journal BioRxiv   Citation bioRxiv 2024.02.26.582084.   Abstract The clustering of L-type calcium channels for functional regulation of intracellular calcium signaling remains poorly understood. Here we applied super-resolution
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25.02.2025

The plastid-encoded RNA polymerase of plant chloroplasts

Authors Ahrens FM, do Prado PFV, Hillen HS, Pfannschmidt T   Journal Trends in Plant Science   Citation Trends Plant Sci. 2025 Feb 25:S1360-1385(25)00031-7.   Abstract Plant chloroplasts possess a dedicated genome (plastome) and a prokaryotic-type plastid-encoded RNA polymerase (PEP) that mediates its expression. PEP is composed of five bacteria-like
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25.02.2025

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

Authors Flores-León M, Outeiro TF   Journal FEBS Journal   Citation FEBS J. 2025 Feb 25.   Abstract A possible consequence of the process of protein aggregation in neurodegenerative diseases is the depletion of soluble protein species (proteinopenia), which may, at least in some cases, reduce protein function/activity. This concept,
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23.02.2025

Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination

Authors Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A, Landt C, Rhee HJ, Rhee J, Gómez-Varela D, Schmidt M, Möbius W, Ruhwedel T, Pardo LA, Remling L, Kramann N, Wrzos C, Bahn E, Stadelmann C, Barrantes-Freer A Journal Journal of Neuroinflammation Citation J Neuroinflammation.
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23.02.2025

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

Authors Zhao XT, Diep DTV, Percifull L, Fausten RM, Hugenroth M, Höhne P, Esch BM, Collado J, Keller J, Wilmes S, Wälte M, Kümmel D, Schuberth C, Fernández-Busnadiego R, Fröhlich F, Wedlich-Söldner R, Bohnert M Journal BioRxiv Citation bioRxiv 2025.02.21.639583. Abstract Organelle motility enables strategic cellular reorganizations. In yeast, this
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21.02.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Mueller GF, Li J, Weiss KR, Roos L, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal BioRxiv Citation bioRxiv 2025.02.21.639411. Abstract Light sheet microscopy is the ideal technique for multiscale imaging of large and cleared tissues, and it is desirable to achieve the highest
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20.02.2025

Direct mechanical communication of cellular to nuclear shape in oocytes

Authors Vos BE, Vadapalli Y, Muenker TM, Jentoft IMA, Todisco E, Eskandari MA, Schuh M, Lenart P, Betz T Journal BioRxiv Citation bioRxiv 2025.02.17.638579. Abstract The mechanical properties of the cytoplasm and nucleoplasm are crucial for the correct and robust functioning of a cell and play a key role in
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18.02.2025

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

Authors Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT Journal Theranostics Citation Theranostics 2025. accepted manuscript. Abstract Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and proof-of-concept
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16.02.2025

Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture

Authors Kowald M, Bachollet SPJT, Benseler F, Steinecker M, Boll M, Kaushik S, Soykan T, Sun S, Birke R, Ilic D, Brose N, Hörnberg H, Lehmann M, Rizzoli SO, Broichhagen J, Lipstein N Journal BioRxiv Citation bioRxiv 2024.10.08.617143. Abstract Synaptic function is governed by highly regulated protein machineries, whose abundance
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