2025

Authors Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschlager J Journal BioRxiv Citation bioRxiv 2025.06.06.657340. Abstract Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent

Authors Pradhan R, Petrovic Z, Sakib MS, Schroeder S, Krueger DM, Pena T, Diniz E, Burkhardt S, Schuetz AL, Grządzielewska I, Toischer K, Stein TD, Blusztajn JK, Delalle I, Radulovic J, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.06.01.657217. Abstract The increasing evidence that non-coding RNAs can become deregulated

Authors Nellen NS, Turishcheva P, Vystrčilová M, Sridhar S, Gollisch T, Tolias AS, Ecker AS Journal Arxiv Citation arXiv:2506.03293. Abstract Deep neural networks trained to predict neural activity from visual input and behaviour have shown great potential to serve as digital twins of the visual cortex. Per-neuron embeddings derived from

Authors Han M, Frieg B, Matthes D, Leonov A, Ryazanov S, Giller K, Nimerovsky E, Stampolaki M, Xue K, Overkamp K, Dienemann C, Riedel D, Giese A, Becker S, de Groot BL, Schroeder G, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.05.30.655790. Abstract Alzheimer’s disease is a specific neurodegenerative

Authors Habeck M, Saleem N, Plota D, Cheruiyot C, Kohl T, Lehnart S, Jakobs S, Ebert A Journal BioRxiv Citation bioRxiv 2025.05.28.655290. Abstract In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess

Authors Müller L, Mallick P, Marín-Carballo AB, Dönges P, Kettlitz RJN, Klett-Tammen CJ, Kretzschmar M, Priesemann V, Contreras S Journal BioRxiv Citation arXiv:2505.24433. Abstract HIV pre-exposure Prophylaxis (PrEP) has become essential for global HIV control, but its implementation coincides with rising bacterial STI rates among men who have sex with

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal BioRxiv Citation bioRxiv 2025.05.28.655569. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games that do not capture

Authors Kloskowski P, Neumann P, Kumar P, Berndt A, Dobbelstein M, Ficner R Journal Acta Crystallographica Section D-Structural Biology Citation Acta Crystallogr D Struct Biol. 2025 Jun 1. Abstract The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target

Authors Cretu C, Chernev A, Szabo CZK, Pena V, Urlaub H, Moser T, Preobraschenski J Journal EMBO Journal Citation EMBO J. 2025 May 28. Abstract Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion. Despite their links to

Authors Aron M, Luther S, Parlitz U Journal Frontiers in Network Physiology Citation Front Netw Physiol. 2025 May 27;5:1572834. Abstract Ventricular fibrillation is a lethal condition where the heartbeat becomes too disorganised to maintain proper circulation. It is treated with defibrillation, which applies an electric shock in an attempt to