2025

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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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16.01.2025

Super-resolution going viral: T4 virus particles as versatile 3D-Bio-NanoRulers

Authors Gallea JI, Nevskyi O, Kaźmierczak Z, Gligonov I, Chen T, Miernikiewicz P, Chizhik AM, Reinkensmeier L, Dąbrowska K, Bates M, Enderlein J Journal Advanced Materials Citation Adv Mater. 2025 Jan 16:e2403365. Abstract In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications
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15.01.2025

Phenotypes linked to duplication upstream of SOX9: New insights into presentation and diagnosis

Authors Unal E, Tekmenuray-Unal A, Cayir A, Papatya Cakir ED, Beyazit N, Kolbasi B, Gurpinar Tosun B, Yigit G, Zibat A, Wollnik B, Demirbilek H, Guran T Journal The Journal of Clinical Endocrinology and Metabolism Citation J Clin Endocrinol Metab. 2025 Jan 15:dgaf020. Abstract Context: Duplications occurring upstream of the
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14.01.2025

Single neuron diversity supports area functional specialization along the visual cortical pathways

Authors Feyerabend M, Pommer S, Jimenez-Sosa MS, Rachel J, Sunstrum JK, Preuss F, Mestern S, Hinkel R, Mietsch M, Viyajraghavan S, Everling S, Treue S, Arnsten AFT, Lewis DA, Wolf F, Murray J, Muller L, McCarroll S, Krienen F, Datta D, Jing Wang X, Tripathy S, Gonzalez-Burgos G, Inoue W,
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10.01.2025

Super-resolution optical fluctuation imaging

Authors Basak S, Chizhik A, Gallea JI, Gligonov I, Gregor I, Nevskyi O, Radmacher N, Tsukanov R, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2025) Abstract We present a comprehensive review of super-resolution optical fluctuation imaging (SOFI), a robust technique that leverages temporal fluctuations in fluorescence intensity to achieve
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09.01.2025

Cardiovascular MRI-derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis

Authors Lange T, Beuthner BE, Schulz A, Backhaus SJ, Evertz R, Rigorth KR, Toischer K, Kowallick JT, Hasenfuss G, Puls M, Schuster A Journal Radiology: Cardiothoracic Imaging Citation Radiol Cardiothorac Imaging. 2025 Feb;7(1):e230380. Abstract Purpose: To assess the prognostic implications of cardiac MRI-derived imaging markers in individuals with severe aortic
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06.01.2025

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

Authors Hehlert P, Effertz T, Gu RX, Nadrowski B, Geurten BRH, Beutner D, de Groot BL, Göpfert MC Journal Nature Neuroscience Citation Nat Neurosci. 2025 Jan 6. Abstract The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have
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03.01.2025

3D multiscale characterization of the human placenta: Bridging anatomy and histology by X-ray phase-contrast tomography

Authors Reichmann J, Schnurpfeil A, Mittelstädt S, Jensen PM, Dahl VA Dahl AB, Weide C, von Campenhausen E, Dejea H, Tafforeau P, Werlein C, Jonigk D, Ackermann M, Engel K, Gallwas J, Dietz A, Hasanov MF, Salditt T Journal PNAS Nexus Citation PNAS Nexus, Volume 4, Issue 1, January 2025,
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02.01.2025

Molecular basis of human nuclear and mitochondrial tRNA 3′-processing

Authors Bhatta A, Kuhle B, Yu RD, Spanaus L, Ditter K, Bohnsack KE, Hillen H Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2025). Abstract Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3′ end processing of
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