2025

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20.01.2025

MedicoSAM: Towards foundation models for medical image segmentation

Authors Archit A, Freckmann L, Pape C Journal Arxiv Citation arXiv:2501.11734. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models or adapting
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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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16.01.2025

Super-resolution going viral: T4 virus particles as versatile 3D-Bio-NanoRulers

Authors Gallea JI, Nevskyi O, Kaźmierczak Z, Gligonov I, Chen T, Miernikiewicz P, Chizhik AM, Reinkensmeier L, Dąbrowska K, Bates M, Enderlein J Journal Advanced Materials Citation Adv Mater. 2025 Jan 16:e2403365. Abstract In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications
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15.01.2025

Phenotypes linked to duplication upstream of SOX9: New insights into presentation and diagnosis

Authors Unal E, Tekmenuray-Unal A, Cayir A, Papatya Cakir ED, Beyazit N, Kolbasi B, Gurpinar Tosun B, Yigit G, Zibat A, Wollnik B, Demirbilek H, Guran T Journal The Journal of Clinical Endocrinology and Metabolism Citation J Clin Endocrinol Metab. 2025 Jan 15:dgaf020. Abstract Context: Duplications occurring upstream of the
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14.01.2025

Single neuron diversity supports area functional specialization along the visual cortical pathways

Authors Feyerabend M, Pommer S, Jimenez-Sosa MS, Rachel J, Sunstrum JK, Preuss F, Mestern S, Hinkel R, Mietsch M, Viyajraghavan S, Everling S, Treue S, Arnsten AFT, Lewis DA, Wolf F, Murray J, Muller L, McCarroll S, Krienen F, Datta D, Jing Wang X, Tripathy S, Gonzalez-Burgos G, Inoue W,
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10.01.2025

Super-resolution optical fluctuation imaging

Authors Basak S, Chizhik A, Gallea JI, Gligonov I, Gregor I, Nevskyi O, Radmacher N, Tsukanov R, Enderlein J Journal Nature Photonics Citation Nat. Photon. (2025) Abstract We present a comprehensive review of super-resolution optical fluctuation imaging (SOFI), a robust technique that leverages temporal fluctuations in fluorescence intensity to achieve
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09.01.2025

LncRNA 3222401L13Rik Is Upregulated in Aging Astrocytes and Regulates Neuronal Support Function Through Interaction with Npas3

Authors Schröder S, Sakib MS, Krüger DM, Pena T, Burkhardt S, Schütz AL, Sananbenesi F, Fischer A Journal Noncoding RNA Citation Noncoding RNA. 2025 Jan 9;11(1):2. Abstract Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute to this
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09.01.2025

Cardiovascular MRI-derived Right Atrial Strain for Improved Risk Stratification in Patients with Severe Aortic Stenosis

Authors Lange T, Beuthner BE, Schulz A, Backhaus SJ, Evertz R, Rigorth KR, Toischer K, Kowallick JT, Hasenfuss G, Puls M, Schuster A Journal Radiology: Cardiothoracic Imaging Citation Radiol Cardiothorac Imaging. 2025 Feb;7(1):e230380. Abstract Purpose: To assess the prognostic implications of cardiac MRI-derived imaging markers in individuals with severe aortic
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06.01.2025

NOMPC ion channel hinge forms a gating spring that initiates mechanosensation

Authors Hehlert P, Effertz T, Gu RX, Nadrowski B, Geurten BRH, Beutner D, de Groot BL, Göpfert MC Journal Nature Neuroscience Citation Nat Neurosci. 2025 Jan 6. Abstract The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have
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06.01.2025

NOMPC ion channel hinge forms a gating-spring that initiates mechanosensation

Authors Hehlert P, Effertz T, Gu RX, Nadrowski B, Geurten BRH, Beutner D, de Groot BL, Göpfert MC Journal Nature Neuroscience Citation Nat Neurosci. 2025 Jan 6. Abstract The sensation of mechanical stimuli is initiated by elastic gating springs that pull open mechanosensory transduction channels. Searches for gating springs have
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