2025

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13.02.2025

A novel alpha-synuclein K58N missense variant in a patient with Parkinson’s disease

Authors Al-Azzani M, Weber S, Ramalingam N, Ramón M, Shvachiy L, Mestre G, Zech M, Sicking K, Ibáñez de Opakua A, Jayanthi V, Amaral L, Agarwal A, Chandran A, Chaves SR, Winkelmann J, Trenkwalder C, Schwager M, Pauli S, Dettmer U, Fernández CO, Lautenschläger J, Zweckstetter M, Fernandez Busnadiego R,
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12.02.2025

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Authors Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, Hua Y, Moser T, Bandtlow C Journal eLife Citation eLife14:RP103481. Abstract Sound encoding depends on the precise and reliable neurotransmission at the afferent synapses between the sensory inner
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12.02.2025

Segment Anything for Microscopy

Authors Archit A, Freckmann L, Nair S, Khalid N, Hilt P, Rajashekar V, Freitag M, Teuber C, Buckley G, von Haaren S, Gupta S, Dengel A, Ahmed S, Pape C Journal Nature Methods Citation Nat Methods. 2025 Feb 12. Abstract Accurate segmentation of objects in microscopy images remains a bottleneck
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11.02.2025

Protein misfolding: understanding biology to classify and treat synucleinopathies

Authors Outeiro TF, Höglinger G, Lang AE, Vieira TCRG Journal Journal of Neural Transmission Citation J Neural Transm (Vienna). 2025 Feb 11. Abstract Protein misfolding and aggregation is a major pathological hallmark in a variety of human conditions, including cancer, diabetes, and neurodegeneration. However, we still do not fully understand
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06.02.2025

Guiding G protein signaling by target enhancement of GPCRs

Authors Mücher B, Garrido-Charles A, Cyganek L, Bruegmann T, Dalkara D, Siveke I, Herlitze S Journal BioRxiv Citation bioRxiv 2025.02.06.636923. Abstract Activation of G protein coupled receptors coupling to the Gi/o pathway leads to the activation of G protein-activated inward rectifier potassium channels (GIRK) in a fast membrane-delimited manner in
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01.02.2025

Unbalanced Kantorovich-Rubinstein distance, plan, and barycenter on finite spaces: A statistical perspective

Authors Hundrieser S, Heinemann F, Klatt M, Struleva M, Munk A Journal Journal of Machine Learning Research Citation Journal of Machine Learning Research 26 (2025) 1-70. Abstract We analyze statistical properties of plug-in estimators for unbalanced optimal transport quantities between finitely supported measures in different prototypical sampling models. Specifically, our
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31.01.2025

Cryo-ET suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules

Authors Chakraborty S, Martinez-Sanchez A, Beck F, Toro-Nahuelpan M, Hwang IY, Noh KM, Baumeister W, Mahamid J Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Feb 4;122(5):e2404017121. Abstract The functional architecture of the long-lived neuronal
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31.01.2025

An avoidance segment resolves a lethal nuclear-mitochondrial targeting conflict during ribosome assembly

Authors Oborská-Oplová M, Geiger AG, Michel E, Klingauf-Nerurkar P, Dennerlein S, Bykov YS, Amodeo S, Schneider A, Schuldiner M, Rehling P, Panse VG Journal Nature Cell Biology Citation Nat Cell Biol. 2025 Jan 31. Abstract The correct sorting of nascent ribosomal proteins from the cytoplasm to the nucleus or to
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30.01.2025

Advanced fluorescence lifetime-enhanced multiplexed nanoscopy of cells

Authors Basak S, Tsukanov R Journal Methods in Microscopy Citation Methods in Microscopy, 2025. Abstract In this review paper, we summarize the significant advancements in the field of fluorescence lifetime imaging microscopy (FLIM), particularly wide-field FLIM with single-molecule sensitivity, achieved using the time-correlated single-photon counting-based position-sensitive LINCam system. Fluorescence lifetime
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29.01.2025

Engineered heart muscle allografts for heart repair in primates and humans

Authors Jebran AF, Seidler T, Tiburcy M, Daskalaki M, Kutschka I, Fujita B, Ensminger S, Bremmer F, Moussavi A, Yang H, Qin X, Mißbach S, Drummer C, Baraki H, Boretius S, Hasenauer C, Nette T, Kowallick J, Ritter CO, Lotz J, Didié M, Mietsch M, Meyer T, Kensah G, Krüger
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