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10.06.2025

Dual effect of alpha-synuclein disease variants on condensate formation

Authors Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschlager J Journal BioRxiv Citation bioRxiv 2025.06.06.657340. Abstract Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent
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03.06.2025

NeuID, a novel neuron-specific lncRNA, resolved a key epigenetic mechanisms linking gene silencing to Alzheimer’s disease

Authors Pradhan R, Petrovic Z, Sakib MS, Schroeder S, Krueger DM, Pena T, Diniz E, Burkhardt S, Schuetz AL, Grządzielewska I, Toischer K, Stein TD, Blusztajn JK, Delalle I, Radulovic J, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.06.01.657217. Abstract The increasing evidence that non-coding RNAs can become deregulated
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01.06.2025

The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation

Authors Han M, Frieg B, Matthes D, Leonov A, Ryazanov S, Giller K, Nimerovsky E, Stampolaki M, Xue K, Overkamp K, Dienemann C, Riedel D, Giese A, Becker S, de Groot BL, Schroeder G, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.05.30.655790. Abstract Alzheimer’s disease is a specific neurodegenerative
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30.05.2025

Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

Authors Habeck M, Saleem N, Plota D, Cheruiyot C, Kohl T, Lehnart S, Jakobs S, Ebert A Journal BioRxiv Citation bioRxiv 2025.05.28.655290. Abstract In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess
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30.05.2025

Testing Paradox May Explain Increased Observed Prevalence of Bacterial STIs among MSM on HIV PrEP: A Modeling Study

Authors Müller L, Mallick P, Marín-Carballo AB, Dönges P, Kettlitz RJN, Klett-Tammen CJ, Kretzschmar M, Priesemann V, Contreras S Journal BioRxiv Citation arXiv:2505.24433. Abstract HIV pre-exposure Prophylaxis (PrEP) has become essential for global HIV control, but its implementation coincides with rising bacterial STI rates among men who have sex with
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28.05.2025

Continuous dynamics of cooperation and competition in social foraging

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal BioRxiv Citation bioRxiv 2025.05.28.655569. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games that do not capture
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12.05.2025

Brain-derived synaptic vesicles have an intrinsic ability to sequester tubulin

Authors Mimoso T, Korobeinikov A, Stein A, Milovanovic D, Rizzoli SO, Köster S, Reshetniak S Journal BioRxiv Citation bioRxiv 2025.05.08.652815 Abstract The presence and function of microtubules within the synaptic bouton has long been under investigation. In recent years evidence has accumulated that connects the synaptic vesicle cluster to the
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11.05.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Kibédi CZ, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal BioRxiv Citation bioRxiv 2025.05.10.653085 Abstract Our sense of hearing relies
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04.05.2025

SarcAsM: AI-based multiscale analysis of sarcomere organization and contractility in cardiomyocytes

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Long J, Tiburcy M, Berecic B, Primeßnig A, Bao G, Cyganek L, Schmidt CF, Zimmermann WH Journal BioRxiv Citation bioRxiv 2025.04.29.650605. Abstract Cardiomyocyte function critically depends on sarcomere dynamics and their organization in myofibrils. To uncover how cardiomyocyte function emerges from
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02.05.2025

Structural basis for no retinal binding in flotillin-associated rhodopsins

Authors Kovalev K, Stetsenko A, Trunk F, Marin E, Haro-Moreno JM, Lamm GHU, Alekseev A, Rodriguez-Valera F, Schneider TR, Wachtveitl J, Guskov A Journal BioRxiv Citation bioRxiv 2025.04.29.651185. Abstract Rhodopsins are light-sensitive membrane proteins capturing solar energy via a retinal cofactor covalently attached to a lysine residue. Several groups of
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