bioRxiv

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10.01.2023

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez O, Hammer E, Steinegger M, Böhmer L, Schroeder H, Kleinsorge M, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal BioRxiv Citation bioRxiv 2023.01.10.523203. Abstract Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset
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10.01.2023

Natural stimuli drive concerted nonlinear responses in populations of retinal ganglion cells

Authors Karamanlis D, Khani MH, Schreyer HM, Zapp SJ, Mietsch M, Gollisch T Journal BioRxiv Citation bioRxiv 2023.01.10.523412. Abstract The role of the vertebrate retina in early vision is generally described by the efficient coding theory, which predicts that the retina discards spatiotemporal correlations in natural scenes. It is unclear,
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09.01.2023

Age-dependent structural reorganization of utricular ribbon synapses

Authors Wichmann C, Michanski S, Henneck T, Mukhopadhyay M, Steyer AM, Agüi Gonzalez P, Grewe K, Ilgen P, Gültas M, Fornasiero EF, Jakobs S, Möbius W, Vogl C, Pangršič T, Rizzoli SO Journal BioRxiv Citation bioRxiv 2022.12.19.521049. Abstract In mammals, spatial orientation is synaptically-encoded by sensory hair cells of the
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04.01.2023

Flotillin-Associated rhodopsin (FArhodopsin), a widespread paralog of proteorhodopsin in aquatic bacteria with streamlined genomes

Authors Haro-Moreno JM, López-Pérez M, Alekseev A, Podoliak E, Kovalev K, Gordeliy V, Stepanauskas R, Rodriguez-Valera F Journal BioRxiv Citation bioRxiv 2023.01.04.522823. Abstract Microbial rhodopsins are often found more than once in a single genome (paralogs) that often have different functions. We screened a large dataset of open ocean single-amplified
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23.12.2022

Dystrophin is a mechanical tension modulator

Authors Hofemeier AD, Muenker TM, Herkenrath F, Ristau M, Brandt M, Shahriyari M, Tiburcy M, Zimmermann WH, Lenz C, Mamchaoui K, Bigot A, Gilbert PM, Betz T Journal BioRxiv Citation bioRxiv 2022.12.23.521750. Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where increasing muscle weakness leads to
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16.12.2022

Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses

Authors Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra KF, Neef J, Strenzke N, Moser T, Wichmann C Journal BioRxiv Citation bioRxiv 2022.12.15.520589. Abstract Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tireless-ly transmit sound
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01.12.2022

Filter-based models of suppression in retinal ganglion cells: comparison and generalization across species and stimuli

Authors Shahidi N, Rozenblit F, Khani MH, Schreyer HM, Mietsch M, Protti DA, Gollisch T Journal BioRxiv Citation bioRxiv 2022.12.01.518577. Abstract The dichotomy of excitation and suppression is one of the canonical mechanisms explaining the complexity of the neural activity. Computational models of the interplay of excitation and suppression in
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27.11.2022

Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse

Authors Hain PJH, Moser T Journal BioRxiv Citation bioRxiv 2022.11.27.518035. Abstract Recently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic function independent of electrophysiological measurement techniques. Here, we express iGluSnFR,
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15.11.2022

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

Authors Stewart H, Lu Y, O’Keefe S, Valpadashi A, Cruz-Zaragoza LD, Michel HA, Nguyen SK, Carnell GW, Lukhovitskaya N, Milligan R, Jungreis I, Lulla V, Davidson AD, Matthews DA, High S, Rehling P, Emmott E, Heeney JL, Edgar JR, Smith GL, Firth AE Journal BioRxiv Citation bioRxiv 2022.11.15.516323 Abstract The
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12.11.2022

Metal-Induced Energy Transfer (MIET) for Live-Cell Imaging with Fluorescent Proteins

Authors Hauke L, Isbaner S, Ghosh A, Guido I, Turco L, Chizhik AI, Gregor I, Karedla N, Rehfeldt F, Enderlein J Journal BioRxiv Citation bioRxiv 2022.11.12.516247. Abstract Metal-Induced Energy Transfer (MIET) imaging is an easy-to-implement super-resolution modality that achieves nanometer resolution along the optical axis of a microscope. Although its
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