bioRxiv

Authors Vasili E, Konig A, Al-Azzani M, Bosbach C, Gatzemeier LM, Chegao A, Miranda HV, Erskine D, Outeiro T Journal BioRxiv Citation bioRxiv 2024.06.27.600956. Abstract The risk of developing Parkinson’s disease (PD) is elevated in people with type 2 diabetes, but the precise molecular pathways underlying this connection are still

Authors Schroeder S, Fuchs U, Gisa V, Pena T, Krueger DM, Hempel N, Burkhardt S, Salinas-Riester G, Schuetz AL, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2024.06.27.600964 Abstract Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of

Authors de Bruyn E, Dorn AE, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P Journal BioRxiv Citation bioRxiv 2023.03.10.531864. Abstract Serine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a key player in Parkinson’s disease and other synucleinopathies. Here, molecular

Authors Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C Journal BioRxiv Citation bioRxiv 2024.06.13.598801. Abstract The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here

Authors Capel RA, Akerman E, Rog-Zielinska E, Winbo A, Aston D, Mu-u-min RBA, Read MJ, Bose SJ, Swietach P, Wang J, Corbett AD, Koschinski A, Montgomery JM, Falter F, Calamaio S, Melgari D, Prevostini R, Rivolta I, Ayagama T, Jenkin I, Simon JN, Fakuade FE, Pronto J, Sharma P, Song

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Zimmermann WH, Schmidt CF Journal BioRxiv Citation bioRxiv 2024.05.28.596183. Abstract Cardiac muscle function emerges from the coordinated contraction of sarcomeres in cardiomyocytes. Sarcomere dynamics are usually inferred from whole-cell or myofibril observations, assuming synchronized, uniform behavior. Here, we investigated how different

Authors Herwerth M, Wyss MT, Schmid NB, Condrau J, Ravotto L, Mateos Melero JM, Kaech A, Bredell G, Thomas C, Stadelmann C, Misgeld T, Bennett JL, Saab AS, Jessberger S, Weber B Journal BioRxiv Citation bioRxiv 2024.05.18.594292. Abstract Mature astrocytes become activated upon non-specific tissue damage and contribute to glial

Authors Zung N, Aravindan N, Boshnakovska A, Valenti R, Preminger N, Jonas F, Yaakov G, Willoughby M, Homberg B, Keller J, Kupervaser M, Dezorella N, Dadosh T, Wolf SG, Itkin M, Malitsky S, Brandis A, Barkai N, Fernandez-Busnadiego R, Reddi A, Rehling P, Rapaport D, Schuldiner M Journal BioRxiv Citation

Authors Amedei H, Paul N, Foo B, Neuenroth L, Lehnart SE, Urlaub H, Lenz C Journal BioRxiv Citation bioRxiv 2024.04.22.590599. Abstract Introduction: Co-fractionation mass spectrometry couples native-like separations of protein/protein complexes with mass spectrometric proteome analysis for global characterization of protein networks. The technique allows for both de novo detection

Authors Zapp SJ, Khani MH, Schreyer HM, Sridhar S, Ramakrishna V, Krueppel S, Mietsch M, Protti DA, Karamanlis D, Gollisch T Journal BioRxiv Citation bioRxiv 2024.04.22.590506. Abstract A standard circuit motif in sensory systems is the pooling of sensory information from an upstream neuronal layer. A downstream neuron thereby collects