bioRxiv

Authors Gallea JI, Karedla N, Wang D, Zhao B, Chen L, Enderlein J, Chen T Journal BioRxiv Citation bioRxiv 2024.09.27.614973. Abstract The dynamic behavior of cellular membranes underpins essential biological processes, including signal transduction, intracellular trafficking, and mechanotransduction. However, simultaneously quantifying lateral molecular diffusion and vertical membrane fluctuations in live

Authors Haertter D, Hauke L, Driehorst T, Nish Ki, Zimmermann W, Schmidt CF Journal BioRxiv Citation bioRxiv 2024.05.28.596183. Abstract Cardiac contraction is driven by the collective action of cardiomyocytes, that contain parallel bundles of myofibrils consisting of linear chains of sarcomeres, the basic force-generating units. The dynamics of individual sarcomeres

Authors Schuh M, Saha D, Manshaei S, Cavazza T, Holubcova S, Maierova B, Zielinska AP, Wartosch L, Blaney M, Elder K Journal BioRxiv Citation bioRxiv 2026.01.08.698387. Abstract Aneuploidy in human eggs, which rises sharply with age, is a leading cause of infertility, IVF failure, and miscarriage. This age-related aneuploidy is

Authors Basak S, Inamdar K, Pollack YG, Albert L, Jans DC, Jakobs S, Enderlein J, Tsukanov R, Opazo F Journal BioRxiv Citation bioRxiv 2025.12.17.694880 Abstract Direct STORM relies on robust fluorophore blinking; observations suggest that AlexaFluor647 underperforms when coupled to nanobodies, thereby undermining the advantages of nanobodies. We show that

Authors Yu B, Sinha M, Mendes Da Silva R, Roelleke U, Burghammer M, Koester S Journal BioRxiv Citation bioRxiv 2025.12.05.692524. Abstract Due to their high penetration depth, X-rays enable us to obtain information from the interior of whole, unsliced cells. Scanning small angle X-ray scattering (SAXS), in particular, reveals real-space

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of

Authors Pradhan R, Sakib MS, Kaurani L, Krueger DM, Pena T, Burckhardt S, Schuetz AL, Kronenberg-Verstee D, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.10.31.685723. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to microglial aging and neurodegenerative disease

Authors Liu Y, Mueller GF, Kowitz L, Chobola T, Weiss K, Maier P, Luo J, Roessing M, Stenzel M, Grueneboom A, Paetzold J, Erturk A, Navab N, Marr C, Chen J, Huisken J, Peng T Journal BioRxiv Citation bioRxiv 2025.10.26.684661. Abstract Selective plane illumination microscopy (SPIM, also known as light

Authors Mukhopadhyay M, Modgekar R, Yang-Hood A, Ohlemiller KK, Militchin V, Xiao M, Shen Z, Rensing NR, Wong M, Lee SJ, Seal RP, Warchol ME, Maloney SE, Yuede CM, Rutherford MA, Pangrsic T Journal BioRxiv Citation bioRxiv 2025.10.15.682551. Abstract Quantal synaptic transmission in vestibular end-organs is glutamatergic. Although genetic deletion

Authors Hofhuis J, Tiburcy M, Hartmann Y, Bersch K, Wagdi A, Gutiérrez-Gutiérrez O, Solano R, Thiele L, Walper M, Göbel M, Hübner W, Berecic B, Casini M, Tirilomis P, Unger A, Lipstein N, Sossalla S, Huser T, Streckfuss-Bömeke K, Elkenani M, Toischer K, Kohlhaas M, Dudek J, Zimmermann WH, Voigt