bioRxiv

Authors Fuchs U, Schroeder S, Pena t, Krueger DM, Burkhardt S, Schuetz AL, Hempel N, Gisa V, Taghavi T, Cortes J, Gertig M, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2026.07.03.736275. Abstract Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their

Authors Benitez-Fuente F, Collado J, Morello-Lopez J, Pagano-Marquez R, Ruiz-Lopez N, Keller J, Botella MA, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2026.06.23.733366. Abstract Membrane contact sites (MCS) between the endoplasmic reticulum (ER) and the plasma membrane (PM) enable direct intermembrane exchange of signals and metabolites. The Extended Synaptotagmins (E-Syts) are

Authors Jenkins B, Frank T Journal BioRxiv Citation bioRxiv 2026.06.17.732810. Abstract Chemical cues guide essential behaviors by signaling food, danger, and social information. A major dimension of chemosensory processing is valence, which biases animals toward approach or avoidance, yet its brain-wide organization in vertebrates remains unclear. Here, we used larval

Authors Merghani M, Gerhardt E, Hesse M, Fahlbusch C, Boecker CA, Outeiro TF Journal BioRxiv Citation bioRxiv 2026.06.12.731951. Abstract Mutations in the LRRK2 gene are the most common genetic cause of both familial and sporadic Parkinson’s disease (PD). LRRK2 belongs to the leucine-rich repeat kinase (LRRK) family. Two members of

Authors Sinha M, Yu B, Mendes da Silva R, Roelleke U, Luley P, Tiburcy M, Zimmermann WH, Burghammer M, Koester S Journal BioRxiv Citation bioRxiv 2026.06.04.730059 Abstract Imaging the structural organization inside cells in their native state is essential for understanding how the arrangement and interactions among molecular components give

Authors Koert E, Götz J, Albrecht N, Vavakou A, Wolf BJ, Moser T Journal BioRxiv Citation bioRxiv 2026.05.16.724905 Abstract When hearing fails, stimulation of the auditory nerve by electrical cochlear implants (eCIs) partially restores hearing, with most eCI users achieving open speech understanding. However, the broad current spread from each

Authors Albrecht N, Koert E, Vavakou A, Roos L, Jablonski L, Marcoleta JP, Cardona Audi J, Alfken J, Aakhte M, Klein E, Salditt T, Huisken J, Ruther P, Mager T, Kusch K, Moser T Journal BioRxiv Citation bioRxiv 2026.05.15.725096 Abstract When hearing fails, cochlear implants (CIs) partially restore auditory perception.

Authors Kurowska M, Miozzo F, Schroeder R, Machnicka MA, Pérez-González R, Merienne K, Fischer A, Barco A, Boutillier AL, Wilczyński B Journal BioRxiv Citation bioRxiv 2026.05.10.724097 Abstract RATIONALE: Environmental enrichment (EE) paradigms in rodents have long demonstrated that enhanced sensory, cognitive, social, and motor stimulation positively impacts brain function, improving

Authors Gligonov I, Loetgering L, Tenopala-Carmona F, Hsieh CL, Gregor I, Enderlein J Journal BioRxiv Citation bioRxiv 2026.04.28.721333 Abstract Optical microscopy is fundamental to modern life-science research, yet interpreting its results requires precise modelling of point spread functions (PSFs) within complex environments. This manuscript introduces a versatile and efficient approach

Authors Rout SR, Kulke M, Droemer M, Wendel M, Cheng TC, Mauck TA, Asgari S, Nemec AA, Shein M, Sato Y, Fukai S, Witte G, Tomko Jr. RJ, Stengel F, Zacharias M, Schuetz AK, Sakata E Journal BioRxiv Citation bioRxiv 2026.04.16.718620 Abstract The multifunctional AAA+ ATPase p97/VCP is a pivotal