bioRxiv

Authors Basak S, Inamdar K, Pollack YG, Albert L, Jans DC, Jakobs S, Enderlein J, Tsukanov R, Opazo F Journal BioRxiv Citation bioRxiv 2025.12.17.694880 Abstract Direct STORM relies on robust fluorophore blinking; observations suggest that AlexaFluor647 underperforms when coupled to nanobodies, thereby undermining the advantages of nanobodies. We show that

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of

Authors Pradhan R, Sakib MS, Kaurani L, Krueger DM, Pena T, Burckhardt S, Schuetz AL, Kronenberg-Verstee D, Delalle I, Sananbenesi F, Fischer A Journal BioRxiv Citation bioRxiv 2025.10.31.685723. Abstract Long non-coding RNAs (lncRNAs) are emerging as key regulators of brain function, but their contribution to microglial aging and neurodegenerative disease

Authors Liu Y, Mueller GF, Kowitz L, Chobola T, Weiss K, Maier P, Luo J, Roessing M, Stenzel M, Grueneboom A, Paetzold J, Erturk A, Navab N, Marr C, Chen J, Huisken J, Peng T Journal BioRxiv Citation bioRxiv 2025.10.26.684661. Abstract Selective plane illumination microscopy (SPIM, also known as light

Authors Hofhuis J, Tiburcy M, Hartmann Y, Bersch K, Wagdi A, Gutiérrez-Gutiérrez O, Solano R, Thiele L, Walper M, Göbel M, Hübner W, Berecic B, Casini M, Tirilomis P, Unger A, Lipstein N, Sossalla S, Huser T, Streckfuss-Bömeke K, Elkenani M, Toischer K, Kohlhaas M, Dudek J, Zimmermann WH, Voigt

Authors Kosmidis E, Fokaeos M, Shuttle CG, Isselstein MC, Cvjetkovic A, Johnson PJ, Pederesen JL, Jahn R, Preobraschenski J, Stamou D Journal BioRxiv Citation bioRxiv 2025.09.28.679038. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases) are rotary proton pumps that establish proton gradients across cellular membranes. Their pharmacological inhibition is currently under active investigation

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2025.09.08.674839. Abstract Wide-field amacrine cells (ACs) play a unique role in retinal processing by integrating visual information across a large spatial area. Their inhibitory influence has been implicated in multiple retinal functions such as differential

Authors Holthusen H, Trinkaus VA, Fernandez Gonzalez C, Saha I, Pachmayr I, Wade OK, Dieser A, Hummel B, Yuste-Checa P, Ehses K, Körner R, Fernández-Busnadiego R, Sawarkar R, Jungmann R, Hipp MS, Hartl FU Journal BioRxiv Citation bioRxiv 2025.09.05.673478. Abstract Protein aggregation in various cellular compartments is a hallmark of

Authors Siems SB, Jung RB, Jahn O, Meschkat M, Michanski S, Lukasik N, Hummert S, Sasmita AO, Mobius W, Benseler F, Brose N, Kramer-Albers EM, Haucke V, Nave KA, Werner HB Journal BioRxiv Citation bioRxiv 2025.09.02.673641. Abstract Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing

Authors Voorn RA, Sternbach M, Bourien J, Komiyama N, Rankovic V, Wolf F, Grant SGN, Vogl C Journal BioRxiv Citation bioRxiv 2025.08.19.671016 Abstract Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that