bioRxiv

Authors Siems SB, Jung RB, Jahn O, Meschkat M, Michanski S, Lukasik N, Hummert S, Sasmita AO, Mobius W, Benseler F, Brose N, Kramer-Albers EM, Haucke V, Nave KA, Werner HB Journal BioRxiv Citation bioRxiv 2025.09.02.673641. Abstract Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing

Authors Voorn RA, Sternbach M, Bourien J, Komiyama N, Rankovic V, Wolf F, Grant SGN, Vogl C Journal BioRxiv Citation bioRxiv 2025.08.19.671016 Abstract Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that

Authors Kumar NH, Kluever V, Kaufmann SV, Bergmann C, Mousaei K, Tomas M, Marrero MC, Chopra A, Hirose M, Pallas M, Sanfeliu C, Ibrahim SM, Fischer A, Outeiro TF, Urlaub H, Tchumatchenko T, Lopez Otin C, Fornasiero EF Journal BioRxiv Citation bioRxiv 2025.08.14.669896 Abstract Brain aging is a major risk

Authors Szöllősi D, Pratihar S, Mukhopadhyay D, Rout AK, Reddy GJ, Ebersberger N, Becker S, Nagy G, Rauscher S, Lee D, Klement R, Griesinger C, Grubmüller H Journal BioRxiv Citation bioRxiv 2025.08.01.668138 Abstract Intrinsically disordered proteins (IDPs) exhibit pronounced structural dynamics, which is crucial for their functional versatility. Yet their

Authors Amin F, Stone JT, König C, Mancini N, Murakami K, Bidaye SS, Heim MM, Owald D, Majumder U, Grunwald Kadow IC, Pierzchlińska A, Litwin-Kumar A, Barnstedt O, Gerber B Journal BioRxiv Citation bioRxiv 2025.07.07.663268. Abstract It was classically suggested that behaviour can cause emotions (Darwin 1872). For example, smiling

Authors Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschlager J Journal BioRxiv Citation bioRxiv 2025.06.06.657340. Abstract Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Long J, Tiburcy M, Berecic B, Primeßnig A, Bao G, Cyganek L, Schmidt CF, Zimmermann WH Journal BioRxiv Citation bioRxiv 2025.04.29.650605. Abstract Cardiomyocyte function critically depends on sarcomere dynamics and their organization in myofibrils. To uncover how cardiomyocyte function emerges from

Authors Gönenc II, Wolff A, Busley AV, Wieland A, Tijhuis A, Müller C, Wardenaar R, Argyriou L, Kaulfuß S, Räschle M, Spierings DCJ, Foijer F, Bastians H, Yigit G, Zibat A, Cyganek L, Wollnik B Journal BioRxiv Citation bioRxiv 2025.04.17.649287. Abstract Biallelic loss-of-function (LoF) variants in the BTRR complex members

Authors Kim M, Matthes D, Frieg B, Leonov A, Ryazanov S, Bleher D,Grotegerd AK, Dienemann C, Giese A, Schröder GF, Becker S, Herfert K, de Groot BL, Andreas LB, Griesinger C Journal BioRxiv Citation bioRxiv 2025.04.21.649837. Abstract Accumulation of α-synuclein (αSyn) aggregates in the human brain is the major hallmark

Authors da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez S, Klein R, Giese A, Griesinger C, Dudanova I Journal BioRxiv Citation bioRxiv 2025.03.11.642540. Abstract Huntington′s disease (HD) is a debilitating hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is