Salditt, Tim

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25.09.2023

Imaging of excised cochleae by micro-CT: staining, liquid embedding, and image modalities

Authors Schaeper JJ, Liberman MC, Salditt T Journal Journal of Medical Imaging Citation J. Med. Imag. 10(5) 053501 (25 September 2023) Abstract Purpose: Assessing the complex three-dimensional (3D) structure of the cochlea is crucial to understanding the fundamental aspects of signal transduction in the inner ear and is a prerequisite
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11.05.2023

Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography

Authors Reichmann J, Verleden SE, Kühnel M, Kamp JC, Werlein C, Neubert L, Müller JH, Bui TQ, Ackermann M, Jonigk D, Salditt T Journal Physics in Medicine and Biology Citation Phys Med Biol. 2023 May 11. Abstract As the central organ of the respiratory system, the human lung is responsible
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02.05.2023

Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography – the next dimension of diagnosis

Authors Pinkert-Leetsch D, Frohn J, Ströbel P, Alves F, Salditt T, Missbach-Guentner J Journal Cancer Imaging Citation Cancer Imaging. 2023 May 2;23(1):43. Abstract Background: The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which still has one of the lowest survival rates, requires novel imaging tools to improve early detection and
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13.04.2023

3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis

Authors Frost J, Schmitzer B, Töpperwien M, Eckermann M, Franz J, Stadelmann C, Salditt T Journal Neuroscience Citation Neuroscience. 2023 Apr 13:S0306-4522(23)00161-6. Abstract We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze
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22.12.2022

On the Fabrication and Characterization of Polymer-Based Waveguide Probes for Use in Future Optical Cochlear Implants

Authors Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D Journal Materials (Basel) Citation Materials (Basel). 2022 Dec 22;16(1):106. Abstract Improved hearing restoration by cochlear implants (CI) is expected
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12.11.2022

Inflammation and vascular remodeling in COVID-19 hearts

Authors Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ,
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25.08.2022

Combined optical fluorescence microscopy and X-ray tomography reveals substructures in cell nuclei in 3D

Authors Wittmeier A, Bernhardt M, Robisch A-L, Cassini C, Osterhoff M, Salditt T, Köster S Journal Biomedical Optics Express Citation Biomed. Opt. Express 13, 4954-4969 (2022) Abstract The function of a biological cell is fundamentally defined by the structural architecture of packaged DNA in the nucleus. Elucidating information about the
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07.08.2022

Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices

Authors Veress B, Peruzzi N, Eckermann M, Frohn J, Salditt T, Bech M, Ohlsson B Journal World Journal of Gastroenterology Citation World J Gastroenterol. Aug 7, 2022; 28(29): 3994-4006. Abstract Background: The enteric nervous system (ENS) is situated along the entire gastrointestinal tract and is divided into myenteric and submucosal
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21.12.2021

3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography

Authors Reichardt M, Moller Jensen P, Andersen Dahl V, Dahl AB, Ackermann M, Shah H, Länger F, Werlein C, Kuehnel MP, Jonigk D, Salditt T Journal Elife Citation eLife 2021;10:e71359. Abstract For the first time, we have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue
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30.11.2021

Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography

Authors Eckermann M, Schmitzer B, van der Meer F, Franz J, Hansen O, Stadelmann C, Salditt T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A . 2021 Nov 30;118(48):e2113835118 Abstract We have studied the three-dimensional (3D) cytoarchitecture of the human hippocampus in
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