Salditt, Tim

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09.11.2020

X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts

Authors Nicolas JD, Khan A, Markus A, Mohamed BA, Toischer K, Alves F, Salditt T Journal Scientific Reports Citation Sci Rep. 2020 Nov 9;10(1):19317. Abstract We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular
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06.10.2020

3d phase-contrast nanotomography of unstained human skin biopsies may identify morphological differences in the dermis and epidermis between subjects

Authors Eckermann M, Peruzzi N, Frohn J, Bech M, Englund E, Veress B, Salditt T, Dahlin LB, Ohlsson B Journal Skin Research and Technology Citation Skin Res Technol. 2020 Oct 6. Abstract BACKGROUND: Enteric neuropathy is described in most patients with gastrointestinal dysmotility and may be found together with reduced
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06.10.2020

X-ray structural analysis of single adult cardiomyocytes: tomographic imaging and micro-diffraction

Authors Reichardt M, Neuhaus C, Nicolas JD, Bernhardt M, Toischer K, Salditt T Journal Biophysical Journal Citation Biophys J. 2020 Oct 6;119(7):1309-1323. Abstract We present a multi-scale imaging approach to characterize the structure of isolated adult murine cardiomyocytes based on a combination of full-field three-dimensional (3d) coherent x-ray imaging and
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09.09.2020

3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method?

Authors Peruzzi N, Veress B, Dahlin LB, Salditt T, Andersson M, Eckermann M, Frohn J, Robisch AL, Bech M, Ohlsson B Journal Scandinavian Journal of Gastroenterology Citation Scand J Gastroenterol. 2020 Oct;55(10):1261-1267. Abstract Objectives: Light microscopical analysis in two dimensions, combined with immunohistochemistry, is presently the gold standard to describe
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20.08.2020

3d Virtual Pathohistology of Lung Tissue from Covid-19 Patients based on Phase Contrast X-ray Tomography

Authors Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, Tzankov A, Werlein C, Kuehnel M, Jonigk D, Salditt T Journal Elife Citation eLife 2020;9:e60408. Abstract We present a three-dimensional (3D) approach for virtual histology and histopathology based on multi-scale phase contrast x-ray tomography, and use this
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18.08.2020

3D virtual histology of human pancreatic tissue by multiscale phase-contrast X-ray tomography

Authors Frohn J, Pinkert-Leetsch D, Missbach-Güntner J, Reichardt M, Osterhoff M, Alves F, Salditt T Journal Journal of Synchrotron Radiation Citation J. Synchrotron Rad. (2020). 27, 1707-1719. Abstract A multiscale three-dimensional (3D) virtual histology approach is presented, based on two configurations of propagation phase-contrast X-ray tomography, which have been implemented
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06.05.2020

Vesicle adhesion in the electrostatic strong- coupling regime studied by time-resolved small-angle X-ray scattering

Authors Komorowski K, Schaeper J, Sztucki M, Sharpnack L, Brehm G, Köster S, Salditt T Journal Soft Matter Citation Soft Matter. 2020 May 6;16(17):4142-4154. Abstract We have used time-resolved small-angle X-ray scattering (SAXS) to study the adhesion of lipid vesicles in the electrostatic strong-coupling regime induced by divalent ions. The
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23.03.2020

Elemental quantification and analysis of structural abnormalities in neurons from Parkinson’s-diseased brains by X-ray fluorescence microscopy and diffraction

Authors Joppe K, Nicolas JD, Grünewald TA, Eckermann M, Salditt T, Lingor P Journal Biomedical Optics Express Citation Biomed. Opt. Express. 2020 11(4). Abstract In this work we use scanning X-ray microscopy to study the structure and elemental composition of neuromelanin-positive neurons in substantia nigra tissue of Parkinson patients (PD) and controls.
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18.03.2020

Multi-Scale X-Ray Phase-Contrast Tomography Of Murine Heart Tissue

Authors Reichardt M, Frohn J, Khan A, Alves F, Salditt T Journal Biomedical Optics Express Citation Biomed Opt Express. 2020 May 1; 11(5): 2633–2651. Abstract The spatial organization of cardiac muscle tissue exhibits a complex structure on multiple length scales, from the sarcomeric unit to the whole organ. Here we
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04.03.2020

Fiber orientation in a whole mouse heart reconstructed by laboratory phase-contrast micro-CT

Authors Reichardt M, Topperwien M, Khan A, Alves F, Salditt T Journal Journal of Medical Imaging Citation J Med Imaging (Bellingham). 2020 Mar;7(2):023501. Abstract Purpose: We present a phase-contrast x-ray tomography study of wild type C57BL/6 mouse hearts as a nondestructive approach to the microanatomy on the scale of the
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