Salditt, Tim

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12.06.2024

X-ray phase-contrast tomography of cells manipulated with an optical stretcher

Authors Burchert JP, Frohn J, Rölleke U, Bruns H, Yu B, Gleber SC, Stange R, Busse M, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Radiat. 2024 Jul 1. Abstract X-rays can penetrate deeply into biological cells and thus allow for examination of their
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27.03.2024

3D imaging of protein aggregates in human neurodegeneration by multiscale X-ray phase-contrast tomography

Authors Reichmann J, Franz J, Eckermann M, Stadelmann C, Salditt T   Journal MedRxiv   Citation medRxiv 2024.03.26.24304193.   Abstract This study leverages X-ray Phase-Contrast Tomography (XPCT) for detailed analysis of neurodegenerative diseases like Alzheimer’s and Parkinson’s, focusing on the 3D visualization and quantification of neuropathological features within fixed human
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25.01.2024

Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations

Authors Alfken J, Neuhaus C, Major A, Taskina A, Hoffmann C, Ganzella M, Petrovic A, Zwicker D, Fernández-Busnadiego R, Jahn R, Milovanovic D, Salditt T Journal European Physical Journey. E, Soft Matter Citation Eur Phys J E Soft Matter. 2024 Jan 25;47(1):8. Abstract We study the formation of vesicle condensates
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02.11.2023

Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs

Authors Shi R, Reichardt M, Fiegle DJ, Küpfer LK, Czajka T, Sun Z, Salditt T, Dendorfer A, Seidel T, Bruegmann T Journal Cardiovascular Research Citation Cardiovasc Res. 2023 Nov 2:cvad141. Abstract Aims: Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches
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25.09.2023

Imaging of excised cochleae by micro-CT: staining, liquid embedding, and image modalities

Authors Schaeper JJ, Liberman MC, Salditt T Journal Journal of Medical Imaging Citation J. Med. Imag. 10(5) 053501 (25 September 2023) Abstract Purpose: Assessing the complex three-dimensional (3D) structure of the cochlea is crucial to understanding the fundamental aspects of signal transduction in the inner ear and is a prerequisite
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11.05.2023

Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography

Authors Reichmann J, Verleden SE, Kühnel M, Kamp JC, Werlein C, Neubert L, Müller JH, Bui TQ, Ackermann M, Jonigk D, Salditt T Journal Physics in Medicine and Biology Citation Phys Med Biol. 2023 May 11. Abstract As the central organ of the respiratory system, the human lung is responsible
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02.05.2023

Three-dimensional analysis of human pancreatic cancer specimens by phase-contrast based X-ray tomography – the next dimension of diagnosis

Authors Pinkert-Leetsch D, Frohn J, Ströbel P, Alves F, Salditt T, Missbach-Guentner J Journal Cancer Imaging Citation Cancer Imaging. 2023 May 2;23(1):43. Abstract Background: The worldwide increase of pancreatic ductal adenocarcinoma (PDAC), which still has one of the lowest survival rates, requires novel imaging tools to improve early detection and
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13.04.2023

3d virtual histology reveals pathological alterations of cerebellar granule cells in multiple sclerosis

Authors Frost J, Schmitzer B, Töpperwien M, Eckermann M, Franz J, Stadelmann C, Salditt T Journal Neuroscience Citation Neuroscience. 2023 Apr 13:S0306-4522(23)00161-6. Abstract We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze
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22.12.2022

On the Fabrication and Characterization of Polymer-Based Waveguide Probes for Use in Future Optical Cochlear Implants

Authors Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D Journal Materials (Basel) Citation Materials (Basel). 2022 Dec 22;16(1):106. Abstract Improved hearing restoration by cochlear implants (CI) is expected
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12.11.2022

Inflammation and vascular remodeling in COVID-19 hearts

Authors Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ,
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