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11.08.2024

Mechanism of Co-Transcriptional Cap-Snatching by Influenza Polymerase

Authors Rotsch AH, Li D, Dupont M, Krischuns T, Oberthuer C, Stelfox A, Lukarska M, Fianu I, Lidschreiber M, Naffakh N, Dienemann C, Cusack S, Cramer P Journal BioRxiv Citation bioRxiv 2024.08.11.607481. Abstract Influenza virus mRNA is stable and competent for nuclear export and translation because it receives a 5′
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08.07.2024

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response

Authors Hendrickson T, Giese A, Fiedler M, Perez W, Reyes-Sanchez E, Reyes-Lozano M, Wang S, Venegas-Zamora L, Provasek V, El-Essawi A, Breitenbach I, Fakuade F, Kutschka I, Schiattarella GG, Voigt N, Valderrábano M, Altamirano F Journal BioRxiv Citation bioRxiv 2024.07.08.602618. Abstract Background: The increasing prevalence of atrial fibrillation (AF) and
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10.06.2024

Lysosomal signalling pathways influence heart rhythm, and regulate atrial function

Authors Capel RA, Akerman E, Rog-Zielinska E, Winbo A, Aston D, Mu-u-min RBA, Read MJ, Bose SJ, Swietach P, Wang J, Corbett AD, Koschinski A, Montgomery JM, Falter F, Calamaio S, Melgari D, Prevostini R, Rivolta I, Ayagama T, Jenkin I, Simon JN, Fakuade FE, Pronto J, Sharma P, Song
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19.05.2024

Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain

Authors Herwerth M, Wyss MT, Schmid NB, Condrau J, Ravotto L, Mateos Melero JM, Kaech A, Bredell G, Thomas C, Stadelmann C, Misgeld T, Bennett JL, Saab AS, Jessberger S, Weber B Journal BioRxiv Citation bioRxiv 2024.05.18.594292. Abstract Mature astrocytes become activated upon non-specific tissue damage and contribute to glial
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12.05.2024

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

Authors Zung N, Aravindan N, Boshnakovska A, Valenti R, Preminger N, Jonas F, Yaakov G, Willoughby M, Homberg B, Keller J, Kupervaser M, Dezorella N, Dadosh T, Wolf SG, Itkin M, Malitsky S, Brandis A, Barkai N, Fernandez-Busnadiego R, Reddi A, Rehling P, Rapaport D, Schuldiner M Journal BioRxiv Citation
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18.04.2024

Cerebellar Ex Vivo Magnetic Resonance Imaging at its Feasibility Limit: Up to 77-Microns Isotropic Resolution using Low-Bandwidth Balanced Steady State Free Precession (LoBa-bSSFP) Sequences and 3T Standard Equipment

Authors Weigel M, Dechent P, Galbusera R, Bahn E, Lu PJ, Kappos L, Brueck W, Stadelmann C, Granziera C Journal BioRxiv Citation bioRxiv 2024.04.18.589707. Abstract Background: Ultra-high-resolution magnetic resonance imaging of the ex vivo brain is increasingly becoming an indispensable tool for studying the morphology and potential pathology of the
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04.04.2024

Three-dimensional multi-target super-resolution microscopy of cells using Metal-Induced Energy Transfer and DNA-PAINT

Authors Oleksiievets N, Mougios N, Jans DC, Hauke L, Thiele JC, Basak S, Jakobs S, Opazo F, Enderlein J, Tsukanov R, Sananbenesi F, Fischer A   Journal BioRxiv   Citation bioRxiv 2024.04.02.587536.   Abstract DNA-points accumulation for imaging in nanoscale topography (DNA-PAINT) is a potent variant of single-molecule localization microscopy
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09.03.2024

Convolutional neural network models of the primate retina reveal adaptation to natural stimulus statistics

Authors Vystrčilová M, Sridhar S, Burg MF, Gollisch T, Ecker AS Journal BioRxiv Citation bioRxiv 2024.03.06.583740. Abstract The diverse nature of visual environments demands that the retina, the first stage of the visual system, encodes a vast range of stimuli with various statistics. The retina adapts its computations to some
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16.02.2024

Near-optimal information relay by the neuronal population of layer 4 barrel cortex

Authors Revah O, Wolf F, Gutnick MJ, Neef A Journal BioRxiv Citation bioRxiv 2024.02.15.580451. Abstract Cortical function reflects the coordinated activities of populations of neurons, which, in turn, depend on the speed with which each neuron can respond to input, as revealed by dynamic gain analysis. In Layer 4 of
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02.01.2024

Thermogenetics for cardiac pacing

Authors Balatskiy AV, Nesterenko AM, Lanin AA, Ovechkina VS, Sabinin SS, Fetisova ES, Moshchenko AA, Jappy D, Sokolov RA, Biglova DZ, Solius GM, Solyus EM, Korolev SV, Podgorny OV, Kelmanson IV, Rozov AV, Fedotov AB, Bruegmann T, Zheltikov AM, Mozhaev AA, Belousov VV Journal BioRxiv Citation bioRxiv 2024.01.02.573885. Abstract Cardiac
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