2026 – Seite 9

07.05.2026

Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

Authors Haertter D, Hauke L, Driehorst T, Nish Ki, Zimmermann W, Schmidt CF Journal eLife Citation eLife13:RP97321. Abstract Cardiac contraction is driven by the collective action of cardiomyocytes, that contain parallel bundles of myofibrils consisting of linear chains of sarcomeres, the basic force-generating units. The dynamics of individual sarcomeres within

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06.05.2026

The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy

Authors Chopra A, Xylaki M, Yin F, Castro-Hernández R, Merghani M, Grande V, Mollenhauer B, Fischer A, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2026 May 6. Abstract N6-methyladenosine (m6A) is the most abundant transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A

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06.05.2026

HFSP-Förderung: Universität Göttingen erforscht Informationsverarbeitung in Zellen

„Rauschen oder Signal? Informationsgenauigkeit am Rande des Jamming-Zustands“ lautet der Titel eines internationalen und interdisziplinären Forschungsprojekts unter der Leitung der Universität Göttingen. Gemeinsam mit der New York University und der Hokkaido-Universität wollen die Wissenschaftlerinnen und Wissenschaftler die biophysikalischen Eigenschaften biologischer und synthetischer Materialien untersuchen und Methoden entwickeln, um die Signalübertragung

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01.05.2026

The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies

Authors Navarro-Flores A, Krüger DM, Kaurani L, Fischer A, Schulze TG, Heilbronner U Journal Molecular Psychiatry Citation Mol Psychiatry. 2026 May 1. Abstract Executive functions (EFs) are meta-cognitive abilities that orchestrate goal-directed behavior (i.e., set-shifting, working memory, and inhibitory control). Despite their strong genetic composition, the development of EFs is

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30.04.2026

Neue Perspektive bei Noonan-Syndrom

Ein Göttinger Forschungsteam unter der Leitung von MBExC Mitglied Dr. Lukas Cyganek, Leiter der Stem Cell Unit in der Klinik für Kardiologie und Pneumologie der Universitätsmedizin Göttingen (UMG), konnte zeigen, dass insbesondere Bindegewebszellen des Herzens, sogenannte kardiale Fibroblasten, eine zentrale krankheitsverursachende Rolle spielen. Bei erkrankten Menschen produzieren diese Zellen vermehrt

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28.04.2026

Universal approach to wave-optical calculations of point spread functions in microscopy (and beyond)

Authors Gligonov I, Loetgering L, Tenopala-Carmona F, Hsieh CL, Gregor I, Enderlein J Journal BioRxiv Citation bioRxiv 2026.04.28.721333 Abstract Optical microscopy is fundamental to modern life-science research, yet interpreting its results requires precise modelling of point spread functions (PSFs) within complex environments. This manuscript introduces a versatile and efficient approach

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24.04.2026

Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: Findings from the Rhineland Study

Authors Melas K, Talevi V, Imtiaz MA, Krüger DM, Pena-Centeno T, Fischer A, Aziz NA, Breteler MMB Journal Molecular Psychiatry Citation Mol Psychiatry. 2026 Apr 24. Abstract MicroRNAs (miRNAs) have been linked to brain disorders, but their relations with hippocampal structure and atrophy remain unexplored. As the hippocampus is pivotal

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20.04.2026

Labeling and imaging of neurons with a genetically encoded autonomous bioluminescence system

Authors Brinker T, Günther A, Kiszka KA, Rhee JS, Gregor C Journal Scientific Reports Citation Sci Rep. 2026 Apr 20;16(1):12892. Abstract The bacterial bioluminescence system, consisting of a luciferase and enzymes for intracellular luciferin synthesis, enables autonomous bioluminescence imaging of mammalian cells. Its continuous light emission without the need for

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18.04.2026

The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP

Authors Rout SR, Kulke M, Droemer M, Wendel M, Cheng TC, Mauck TA, Asgari S, Nemec AA, Shein M, Sato Y, Fukai S, Witte G, Tomko Jr. RJ, Stengel F, Zacharias M, Schuetz AK, Sakata E Journal BioRxiv Citation bioRxiv 2026.04.16.718620 Abstract The multifunctional AAA+ ATPase p97/VCP is a pivotal

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16.04.2026

Distributional Convergence of Empirical Entropic Optimal Transport and Statistical Applications

Authors Arenas-Velilla S, Munk A, Rodríguez LA Journal Arxiv Citation arXiv:2604.12940 Abstract Recently, the statistical properties of empirical Entropic Optimal Transport (EOT) have attracted great interest, as this quantity has been shown to be useful for complex data analysis, among other reasons due to its computational efficiency. In several applications,

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