Nature Communications

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28.08.2025

Translational repression by 4E-T is crucial to maintain the prophase-I arrest in vertebrate oocytes

Authors Heim A, Cheng S, Orth J, Stengel F, Schuh M, Mayer TU Journal Nature Communications Citation Nat Commun. 2025 Aug 28;16(1):8051. Abstract Meiotic maturation of vertebrate oocytes occurs in the near-absence of transcription. Thus, female fertility relies on timely translational activation of maternal transcripts stockpiled in full-grown prophase-I-arrested oocytes.
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12.07.2025

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis

Authors Chouaib AA, Chang HF, Khamis OM, Alawar N, Echeverry S, Demeersseman L, Elizarova S, Daniel JA, Tian Q, Lipp P, Fornasiero EF, Valitutti S, Barg S, Pape C, Shaib AH, Becherer U Journal Nature Communications Citation Nat Commun. 2025 Jul 12;16(1):6450. Abstract Activity recognition in live-cell imaging is labor-intensive
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10.07.2025

Super-resolution microscopy of mitochondrial mRNAs

Authors Stoldt S, Maass F, Weber M, Dennerlein S, Ilgen P, Gaertner J, Canfes A, Schweighofer SV, Jans DC, Rehling P, Jakobs S Journal Nature Communications Citation Nat Commun. 2025 Jul 10;16(1):6391. Abstract Mitochondria contain their own DNA (mtDNA) and a dedicated gene expression machinery. As the mitochondrial dimensions are
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17.04.2025

Coupling of ribosome biogenesis and translation initiation in human mitochondria

Authors Heinrichs M, Finke AF, Aibara S, Krempler A, Boshnakovska A, Rehling P, Hillen HS, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2025 Apr 17;16(1):3641. Abstract Biogenesis of mitoribosomes requires dedicated chaperones, RNA-modifying enzymes, and GTPases, and defects in mitoribosome assembly lead to severe mitochondriopathies in humans. Here, we
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13.03.2025

A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics

Authors Maupérin M, Sun Y, Glandorf T, Oswald TA, Klatt N, Geil B, Mutero-Maeda A, Méan I, Jond L, Janshoff A, Yan J, Citi S Journal Nature Communications Citation Nat Commun. 2025 Mar 13;16(1):2514. Abstract Cytoplasmic β- and γ-actin isoforms, along with non-muscle myosin 2 isoforms, are tightly regulated in
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06.03.2025

Structural basis of Nipah virus RNA synthesis

Authors Sala FA, Ditter K, Dybkov O, Urlaub H, Hillen HS Journal Nature Communications Citation Nat Commun. 2025 Mar 6;16(1):2261. Abstract Nipah virus (NiV) is a non-segmented negative-strand RNA virus (nsNSV) with high pandemic potential, as it frequently causes zoonotic outbreaks and can be transmitted from human to human. Its
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17.01.2025

Lipidic folding pathway of α-Synuclein via a toxic oligomer

Authors Sant V, Matthes D, Mazal H, Antonschmidt L, Wieser F, Movellan KT, Xue K, Nimerovsky E, Stampolaki M, Nathan M, Riedel D, Becker S, Sandoghdar V, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2025 Jan 17;16(1):760. Abstract Aggregation intermediates play a pivotal role
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20.11.2024

Two mechanisms repress cyclin B1 translation to maintain prophase arrest in mouse oocytes

Authors Cheng S, Schuh M Journal Nature Communications Citation Nat Commun. 2024 Nov 20;15(1):10044. Abstract In mammals, oocytes are arrested in prophase of meiosis I for long periods of time. Prophase arrest is critical for reproduction because it allows oocytes to grow to their full size to support meiotic maturation
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10.10.2024

NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals

Authors Mougios N, Cotroneo ER, Imse N, Setzke J, Rizzoli S, Simeth NA, Tsukanov R, Opazo F Journal Nature Communications Citation Nat Commun. 2024 Oct 10;15(1):8771. Abstract Fluorescence microscopy has long been a transformative technique in biological sciences. Nevertheless, most implementations are limited to a few targets, which have been
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31.08.2024

The heart is a resident tissue for hematopoietic stem and progenitor cells in zebrafish

Authors Bornhorst D, Hejjaji AV, Steuter L, Woodhead NM, Maier P, Gentile A, Alhajkadour A, Santis Larrain O, Weber M, Kikhi K, Guenther S, Huisken J, Tamplin OJ, Stainier DYR, Gunawan F Journal Nature Communications Citation Nat Commun. 2024 Aug 31;15(1):7589. Abstract The contribution of endocardial cells (EdCs) to the
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