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10.04.2024

A novel subgroup of light-driven sodium pumps with an additional Schiff base counterion

Authors Podoliak E, Lamm GHU, Marin E, Schellbach AV, Fedotov DA, Stetsenko A, Asido M, Maliar N, Bourenkov G, Balandin T, Baeken C, Astashkin R, Schneider TR, Bateman A, Wachtveitl J, Schapiro I, Busskamp V, Guskov A, Gordeliy V, Alekseev A, Kovalev K Journal Nature Communications Citation Nat Commun. 2024
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19.03.2024

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

Authors Gersteuer F, Morici M, Gabrielli S, Fujiwara K, Safdari HA, Paternoga H, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2431.   Abstract Nascent polypeptide chains can induce translational stalling to regulate gene expression. This is exemplified by the E. coli
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19.03.2024

RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Authors Morici M, Gabrielli S, Fujiwara K, Paternoga H, Beckert B, Bock LV, Chiba S, Wilson DN   Journal Nature Communications   Citation Nat Commun. 2024 Mar 19;15(1):2432.   Abstract Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-positive and Gram-negative bacteria, where they are thought to
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13.03.2024

Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications

Authors Chelban V, Aksnes H, Maroofian R, LaMonica LC, Seabra L, Siggervåg A, Devic P, Shamseldin HE, Vandrovcova J, Murphy D, Richard AC, Quenez O, Bonnevalle A, Zanetti MN, Kaiyrzhanov R, Salpietro V, Efthymiou S, Schottlaender LV, Morsy H, Scardamaglia A, Tariq A, Pagnamenta AT, Pennavaria A, Krogstad LS, Bekkelund
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11.03.2024

The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3′-UTR and promoting Rag1 mRNA expression

Authors Xu M, Ito-Kureha T, Kang HS, Chernev A, Raj T, Hoefig KP, Hohn C, Giesert F, Wang Y, Pan W, Ziętara N, Straub T, Feederle R, Daniel C, Adler B, König J, Feske S, Tsokos GC, Wurst W, Urlaub H, Sattler M, Kisielow J, Wulczyn FG, Łyszkiewicz M, Heissmeyer
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27.02.2024

Measuring sub-nanometer undulations at microsecond temporal resolution with metal- and graphene-induced energy transfer spectroscopy

Authors Chen T, Karedla N, Enderlein J Journal Nature Communications Citation Nat Commun. 2024 Feb 27;15(1):1789. Abstract Out-of-plane fluctuations, also known as stochastic displacements, of biological membranes play a crucial role in regulating many essential life processes within cells and organelles. Despite the availability of various methods for quantifying membrane
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13.02.2024

Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)

Authors Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, Andreas LB, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2024 Feb 13;15(1):1297. Abstract Alzheimer’s disease (AD) is a progressive and incurable neurodegenerative disease characterized by the extracellular deposition of amyloid plaques. Investigation into the
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02.01.2024

Hijacking of internal calcium dynamics by intracellularly residing viral rhodopsins

Authors Eria-Oliveira AS, Folacci M, Chassot AA, Fedou S, Thézé N, Zabelskii D, Alekseev A, Bamberg E, Gordeliy V, Sandoz G, Vivaudou M Journal Nature Communications Citation Nat Commun. 2024 Jan 2;15(1):65. Abstract Rhodopsins are ubiquitous light-driven membrane proteins with diverse functions, including ion transport. Widely distributed, they are also
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23.10.2023

Synapsin condensation controls synaptic vesicle sequestering and dynamics

Authors Hoffmann C, Rentsch J, Tsunoyama TA, Chhabra A, Aguilar Perez G, Chowdhury R, Trnka F, Korobeinikov AA, Shaib AH, Ganzella M, Giannone G, Rizzoli SO, Kusumi A, Ewers H, Milovanovic D Journal Nature Communications Citation Nat Commun. 2023 Oct 23;14(1):6730. Abstract Neuronal transmission relies on the regulated secretion of
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11.10.2023

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

Authors Klein AD, Outeiro TF Journal Nature Communications Citation Nat Commun. 2023 Oct 11;14(1):6383. Abstract β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly
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