Nature Communications

Home >> Publications >> Journal >> Nature Communications >> Page 2
Feature image not available
11.10.2023

Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria

Authors Klein AD, Outeiro TF Journal Nature Communications Citation Nat Commun. 2023 Oct 11;14(1):6383. Abstract β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly
Learn More
Feature image not available
05.09.2023

Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm

Authors Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB Journal Nature Communications Citation Nat Commun. 2023 Sep 5;14(1):5395. Abstract The reaction of CO2 with H2O to form bicarbonate (HCO3−) and H+ controls sperm motility and fertilization via HCO3−-stimulated cAMP synthesis. A complex
Learn More
Feature image not available
08.08.2023

Modulation of translational decoding by m6A modification of mRNA

Authors Jain S, Koziej L, Poulis P, Kaczmarczyk I, Gaik M, Rawski M, Ranjan N, Glatt S, Rodnina MV Journal Nature Communications Citation Nat Commun. 2023 Aug 8;14(1):4784. Abstract N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding
Learn More
Feature image not available
14.04.2023

IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Authors Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Böckmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann
Learn More
Feature image not available
31.03.2023

Effects of cryo-EM cooling on structural ensembles

Authors Bock LV, Grubmüller H Journal Nature Communications Citation Nat Commun. 2022 Mar 31;13(1):1709. Abstract Structure determination by cryo electron microscopy (cryo-EM) provides information on structural heterogeneity and ensembles at atomic resolution. To obtain cryo-EM images of macromolecules, the samples are first rapidly cooled down to cryogenic temperatures. To what
Learn More
Feature image not available
02.02.2023

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

Authors Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS Journal Nature Communications Citation Nat Commun. 2023 Feb 2;14(1):560. Abstract Amyloid-like aggregates of the microtubule-associated protein Tau
Learn More
Feature image not available
10.11.2022

The 3D structure of lipidic fibrils of α-synuclein

Authors Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, de Groot BL, Andreas LB, Becker S, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2022 Nov 10;13(1):6810. Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-synucleinopathies, such as Parkinson’s disease,
Learn More
Feature image not available
27.10.2022

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

Authors Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2022 Oct 27;13(1):6406. Abstract Translation termination requires release factors that read a STOP codon in the decoding center and subsequently facilitate the hydrolysis of the nascent peptide chain from the peptidyl
Learn More
Feature image not available
14.09.2022

The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils

Authors Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB Journal Nature Communications Citation Nat Commun. 2022 Sep 14;13(1):5385. Abstract Aggregation of amyloidogenic proteins is a characteristic of
Learn More
Feature image not available
01.04.2022

Selective optogenetic control of Gq signaling using human Neuropsin

Authors Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T Journal Nature Communications Citation Nat Commun. 2022 Apr 1;13(1):1765. Author Correction: Nat Commun.
Learn More
X

Open Positions

EN DE
X
X