Release Date

Authors Jochheim FA, Tegunov D, Hillen HS, Schmitzova J, Kokic G, Dienemann C, Cramer P Journal Communications Biology Citation Commun Biol. 2021 Aug 24;4(1):999. Abstract The coronavirus SARS-CoV-2 uses an RNA-dependent RNA polymerase (RdRp) to replicate and transcribe its genome. Previous structures of the RdRp revealed a monomeric enzyme composed

Authors Santos GL, Meyer T, Tiburcy M, DeGrave A, Zimmermann WH, Lutz S Journal Journal of Visualized Experiments Citation J Vis Exp. 2021 Aug 20;(174). Abstract Fibroblasts are phenotypically highly dynamic cells, which quickly transdifferentiate into myofibroblasts in response to biochemical and biomechanical stimuli. The current understanding of fibrotic processes,

Authors Oestreicher D, Picher MM, Rankovic V, Moser T, Pangrsic T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 2021, 14:689415. Abstract Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. However, future gene therapy promises restoration of

Authors Khuller K, Yigit G, Grijalva CM, Altmüller J, Thiele H, Nürnberg P, Elcioglu NH, Yeter B, Hehr U, Stein A, Della Marina A, Köninger A, Depienne C, Kaiser FJ, Wollnik B, Kuechler A Journal European Journal of Medical Genetics Citation Eur J Med Genet. 2021 Aug 13:104310. Abstract MFSD2A,

Authors Steinmetz M, Stümpfig T, Seehase M, Schuster A, Kowallick J, Müller M, Unterberg-Buchwald C, Kutty S, Lotz J, Uecker M, Paul T Journal Circulation: Cardiovascular Imaging Citation Circ Cardiovasc Imaging. 2021 Aug;14(8):e011823. Abstract Background: Correction of tetralogy of Fallot (cTOF) often results in pulmonary valve pathology and right ventricular

Authors Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2021). 2021 Aug 11. Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of

Authors Bäuerlein FJB, Baumeister W Journal Journal of Molecular Biology Citation J Mol Biol. 2021 Aug 9:167187. Abstract Traditionally, structural biologists approach the complexity of cellular proteomes in a reductionist manner. Proteomes are fractionated, their molecular components purified and studied one-by-one using the experimental methods for structure determination at their

Authors Ghosh A, Enderlein J Journal Current Opinion in Structural Biology Citation Curr Opin Struct Biol. 2021 Aug 6;70:123-131. Abstract We present the recent developments and advances in fluorescence correlation spectroscopy (FCS) and their application to the investigation of biomolecular conformations. In particular, we present and discuss three techniques: multichannel

Authors Zimmermann WH Journal Cardiovascular Research Citation Cardiovasc Res. 2021 Aug 4:cvab229. Abstract No Abstract available. DOI 10.1093/cvr/cvab229 Pubmed Link  

Authors Kulaitis G, Munk A, Werner F Journal The Annals of Statistic Citation Ann. Statist. 49(4): 2292-2312 (August 2021). Abstract As a general rule of thumb the resolution of a light microscope (i.e., the ability to discern objects) is predominantly described by the full width at half maximum (FWHM) of