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15.12.2021

Super-resolution imaging: when biophysics meets nanophotonics

Authors Koenderink AF, Tsukanov R, Enderlein J, Izeddin I, Krachmalnicoff V Journal Nanophotonics Citation Nanophotonics, vol. 11, no. 2, 2022, pp. 169-202. Abstract Probing light–matter interaction at the nanometer scale is one of the most fascinating topics of modern optics. Its importance is underlined by the large span of fields
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09.12.2021

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

Authors Wegener JW, Wagdi A, Wagner E, Katschinski DM, Hasenfuss G, Bruegmann T, Lehnart SE Journal Frontiers in Physiology Citation Front Physiol. 2021 Dec 9;12:777770. Abstract Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop
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08.12.2021

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

Authors Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO Journal Nature Communications Citation Nat Commun. 2021 Dec 8;12(1):7129. Abstract The brain extracellular matrix (ECM) consists of
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01.12.2021

Posterior analysis of n in the binomial (n,p) problem with both parameters unknown — with applications to quantitative nanoscopy

Authors Schmidt-Hieber J, Schneider LF, Staudt T, Krajina A, Aspelmeier T, Munk A Journal The Annals of Statistics Citation Ann. Statist. 49(6): 3534-3558 (December 2021). Abstract Estimation of the population size n from k i.i.d. binomial observations with unknown success probability p is relevant to a multitude of applications and
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30.11.2021

Three-dimensional virtual histology of the human hippocampus based on phase-contrast computed tomography

Authors Eckermann M, Schmitzer B, van der Meer F, Franz J, Hansen O, Stadelmann C, Salditt T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A . 2021 Nov 30;118(48):e2113835118 Abstract We have studied the three-dimensional (3D) cytoarchitecture of the human hippocampus in
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24.11.2021

The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels

Authors Brüser C, Keller-Findeisen J, Jakobs S Journal Cell Reports Citation Cell Reports 37, 110000, November 23, 2021. Abstract In human cells, generally a single mitochondrial DNA (mtDNA) is compacted into a nucleoprotein complex denoted the nucleoid. Each cell contains hundreds of nucleoids, which tend to cluster into small groups.
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19.11.2021

Advanced Data Analysis for Fluorescence-Lifetime Single-Molecule Localization Microscopy

Authors Thiele JC, Nevskyi O, Helmerich DA, Sauer M, Enderlein J Journal Frontiers in Bioinformatics Citation Frontiers Bioinformatics 1, 56, (2021). Abstract Fluorescence-lifetime single molecule localization microscopy (FL-SMLM) adds the lifetime dimension to the spatial super-resolution provided by SMLM. Independent of intensity and spectrum, this lifetime information can be used,
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18.11.2021

Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review

Authors Müllenbroich MC, Kelly A, Acker C, Bub G, Bruegmann T, Di Bona A, Entcheva E, Ferrantini C, Kohl P, Lehnart SE, Mongillo M, Parmeggiani C, Richter C, Sasse P, Zaglia T, Sacconi L, Smith GL Journal Frontiers in Physiology Citation Front Physiol. 2021 Nov 18;12:769586. Abstract Optical techniques for
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15.11.2021

Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography

Authors Eckermann M, van der Meer F, Cloetens P, Ruhwedel T, Möbius W, Stadelmann C, Salditt T Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 7582-7598 (2021). Abstract In this work, we optimize the setups and experimental parameters of X-ray phase-contrast computed-tomography for the three-dimensional imaging of the cyto-
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11.11.2021

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Authors Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer
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