2025

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27.10.2025

Leonardo: a toolset to correct sample-induced artifacts in light sheet microscopy images

Authors Liu Y, Mueller GF, Kowitz L, Chobola T, Weiss K, Maier P, Luo J, Roessing M, Stenzel M, Grueneboom A, Paetzold J, Erturk A, Navab N, Marr C, Chen J, Huisken J, Peng T Journal BioRxiv Citation bioRxiv 2025.10.26.684661. Abstract Selective plane illumination microscopy (SPIM, also known as light
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25.10.2025

The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility

Authors Zhao XT, Diep DTV, Percifull L, Fausten RM, Hugenroth M, Höhne P, Leite B, Esch BM, Collado J, Keller J, Wilmes S, Turhan MA, Wälte M, Becker T, Kümmel D, Schuberth C, Fernández-Busnadiego R, Fröhlich F, Wedlich-Söldner R, Bohnert M Journal Cell Reports Citation Cell Rep 44, 116475, Nov
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24.10.2025

EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling

Authors Ulmke PA, Sakib MS, Nguyen DT, Muchamedin A, Sokpor G, Pham L, Xie Y, Abbas E, Castro Hernandez R, Narayanan R, Wincent J, Liedén A, Harris E, Joss S, Fischer A, Staiger JF, Nguyen HP, Tuoc T Journal Brain Citation Brain. 2025 Oct 24:awaf405. Abstract The evolutionarily conserved RNA
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23.10.2025

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Authors Vasili E, König A, Al-Azzani M, Bosbach C, Gatzemeier LM, Thom S, Chegão A, Miranda HV, Steinem C, Erskine D, Outeiro TF Journal NPJ Parkinsons Disease Citation NPJ Parkinsons Dis. 2025 Oct 23;11(1):307. Abstract The risk of developing Parkinson’s disease (PD) is elevated in individuals with type 2 diabetes
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23.10.2025

International expert consensus on gene therapy for hereditary hearing loss: based on clinical trials

Authors Fan X, Gao Z, Zhong J, Chen Y, Chen X, Landegger LD, Moser T, Zeng FG, Sun Y, Jin X, Nash R, Chien WW, Jiang D, Greinwald JH, Bance M, Rodríguez MM, Lee SY, Feng G, Yang H, Wu CC, Xu L, Yuan W, Feng Y, Zhao Y, Vona
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22.10.2025

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Authors Asadollahi R, Ahmad A, Boonsawat P, Shahanoor Hinzen J, Lohse M, Bouazza-Arostegui B, Sun S, Utesch T, Sommer JD, Ilic D, Padmanarayana M, Fischermanns K, Ranjan M, Boll M, Ka C, Piton A, Mattioli F, Isidor B, Õunap K, Reinson K, Wojcik MH, Marshall CR, Mercimek-Andrews S, Matsumoto N,
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22.10.2025

Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions

Authors Avilov I, Horokhovskyi Y, Mehta P, Welp L, Jakobi J, Cai M, Orzechowski A, Urlaub H, Liepe J, Lenart P Journal Journal of Cell Biology Citation J Cell Biol. 2025 Dec 1;224(12):e202312140. Abstract The Mos kinase activates the ERK/MAPK pathway during oocyte meiosis, controlling essential meiotic functions in species
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20.10.2025

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Authors Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, Hua Y, Moser T, Bandtlow C Journal eLife Citation Elife. 2025 Oct 20;14:RP103481 Abstract Sound encoding depends on the precise and reliable neurotransmission at the afferent synapses between
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17.10.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Sciende Advances Citation Sci Adv. 2025 Oct 17;11(42):eady8532. Abstract Hearing
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16.10.2025

Nanoscale architecture and dynamics of CaV1.3 channel clusters in cardiac myocytes revealed by single channel nanoscopy

Authors Schwenzer N, Tsukanov R, Kohl T, Basak S, Sobitov I, Seibertz F, Kapoor R, Voigt N, Enderlein J, Lehnart SE   Journal Journal of Molecular and Cellular Cardiology Plus   Citation J Mol Cell Cardiol Plus. 14 (2025) 100490.   Abstract The clustering of L-type calcium channels (LTCC) for
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