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09.10.2020

Confocal Fluorescence-Lifetime Single-Molecule Localization Microscopy

Authors Thiele JC, Helmerich DA, Oleksiievets N, Tsukanov R, Butkevich E, Sauer M, Nevskyi O, Enderlein J Journal ACS Nano Citation ACS Nano. 2020 Oct 9. Abstract Fluorescence lifetime imaging microscopy is an important technique that adds another dimension to intensity and color acquired by conventional microscopy. In particular, it
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08.10.2020

Viral rhodopsins 1 are an unique family of light-gated cation channels

Authors Zabelskii D, Alekseev A, Kovalev K, Rankovic V, Balandin T, Soloviov D, Bratanov D, Savelyeva E, Podolyak E, Volkov D, Vaganova D, Astashkin R, Chizhov I, Yutin N, Rulev M, Popov A, Eria-Oliveira AS, Rokitskaya T, Mager T, Antonenko Y, Rosselli R, Armeev G, Shaitan K, Vivaudou M, Büldt
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07.10.2020

Time-resolved MIET measurements of blood platelet spreading and adhesion

Authors Zelená A, Isbaner S, Ruhlandt D, Chizhik A, Cassini C, Klymchenko AS, Enderlein J, Chizhik A, Köster S Journal Nanoscale Citation Nanoscale. 2020 Nov 7;12(41):21306-21315. Abstract Human blood platelets are non-nucleated fragments of megacaryocytes and of high importance for early hemostasis. To form a blood clot, platelets adhere to
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07.10.2020

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide

Authors Montiel V, Bella R, Michel LYM, Esfahani H, De Mulder D, Robinson EL, Deglasse JP, Tiburcy M, Chow PH, Jonas JC, Gilon P, Steinhorn B, Michel T, Beauloye C, Bertrand L, Farah C, Dei Zotti F, Debaix H, Bouzin C, Brusa D, Horman S, Vanoverschelde JL, Bergmann O, Gilis
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07.10.2020

Heterozygous truncating variants in SUFU cause congenital ocular motor apraxia

Authors Schröder S, Li Y, Yigit G, Altmüller J, Bader I, Bevot A, Biskup S, Dreha-Kulaczewski S, Christoph Korenke G, Kottke R, Mayr JA, Preisel M, Toelle SP, Wente-Schulz S, Wortmann SB, Hahn H, Boltshauser E, Uhmann A, Wollnik B, Brockmann K Journal Genetics in Medicine Citation Genet Med. 2020
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06.10.2020

Structural Biology of RNA Polymerase II Transcription: 20 Years On

Authors Osman S, Cramer P Journal Annual Review of Cell and Developmental Biology Citation Annu Rev Cell Dev Biol. 2020 Oct 6;36:1-34. Abstract Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the eukaryotic genome and a focal point for cellular regulation during
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06.10.2020

3d phase-contrast nanotomography of unstained human skin biopsies may identify morphological differences in the dermis and epidermis between subjects

Authors Eckermann M, Peruzzi N, Frohn J, Bech M, Englund E, Veress B, Salditt T, Dahlin LB, Ohlsson B Journal Skin Research and Technology Citation Skin Res Technol. 2020 Oct 6. Abstract BACKGROUND: Enteric neuropathy is described in most patients with gastrointestinal dysmotility and may be found together with reduced
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06.10.2020

X-ray structural analysis of single adult cardiomyocytes: tomographic imaging and micro-diffraction

Authors Reichardt M, Neuhaus C, Nicolas JD, Bernhardt M, Toischer K, Salditt T Journal Biophysical Journal Citation Biophys J. 2020 Oct 6;119(7):1309-1323. Abstract We present a multi-scale imaging approach to characterize the structure of isolated adult murine cardiomyocytes based on a combination of full-field three-dimensional (3d) coherent x-ray imaging and
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05.10.2020

Increased expression of myelin-associated genes in frontal cortex of SNCA overexpressing rats and Parkinson’s disease patients

Authors Hentrich T, Wassouf Z, Ehrhardt C, Haas E, Mills JD, Aronica E, Outeiro TF, Hübener-Schmid J, Riess O, Casadei N, Schulze-Hentrich JM Journal Aging Citation Aging (Albany NY). 2020 Oct 5;12. Abstract Parkinson’s disease (PD) is an age-dependent neurodegenerative disorder. Besides characteristic motor symptoms, patients suffer from cognitive impairments
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02.10.2020

Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations

Authors Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2020 Oct 2;21(19):E7298. Abstract Synapses play a central role for the processing of information in the brain and have been analyzed in countless biochemical, electrophysiological, imaging, and computational
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