Authors
Pein F, Eltzner B, Munk A
Journal
European Biophysics Journal
Citation
Eur Biophys J. 2021 Apr 9.
Abstract
Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free multiscale idealization methodology JSMURF, JULES, and HILDE. We provide an operational manual how to use the accompanying software available as an R-package and as a graphical user interface. This includes selection of the right approach and tuning of parameters. We also discuss advantages and disadvantages of model-free approaches in comparison to hidden Markov model approaches and explain how they complement each other.
DOI
10.1007/s00249-021-01506-8
Pubmed Link
