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02.01.2024

Thermogenetics for cardiac pacing

Authors Balatskiy AV, Nesterenko AM, Lanin AA, Ovechkina VS, Sabinin SS, Fetisova ES, Moshchenko AA, Jappy D, Sokolov RA, Biglova DZ, Solius GM, Solyus EM, Korolev SV, Podgorny OV, Kelmanson IV, Rozov AV, Fedotov AB, Bruegmann T, Zheltikov AM, Mozhaev AA, Belousov VV Journal BioRxiv Citation bioRxiv 2024.01.02.573885. Abstract Cardiac
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28.11.2023

Structure and dynamics of human cardiac fibroblast nanotubes

Authors Schmid-Herbstritt SC, Stief G, Greiner J, Felekary A, Madl J, Zeidler V, Heer J, Iaconianni P, Koch M, Kollmar K, Walz C, Nubling S, Kok T, Pronto JR, Kutschka I, Voigt N, Morgan G, Dienert J, Brox T, Briquez P, Peyronnet R, Rohrbach A, Kohl P, Rog-Zielinska EA Journal
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17.11.2023

Prediction mismatch responses arise as corrections of a predictive spiking code

Authors van Driel K, Rudelt L, Priesemann V, Mikulasch FA Journal Biorxiv Citation bioRxiv 2023.11.16.567335. Abstract Prediction mismatch responses in cortex seem to signal the difference between an internal model of the animal and sensory observations. Often these responses are interpreted as evidence for the existence of error neurons, which
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19.08.2023

Bioengineering of a human innervated cardiac muscle model

Authors Schneider LV, Bao G, Methi A, Jensen O, Schmoll KA, Setya MG, Sakib MS, Fahud AL, Brockmoeller J, Fischer A, Liaw NY, Zimmermann WH, Zafeiriou MP Journal BioRxiv Citation bioRxiv 2023.08.18.552653. Abstract Cardiac autonomic neurons control cardiac contractility. Dysregulation of the autonomic nervous system can lead to sympathetic overdrive
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30.06.2023

Cryo-electron tomography of large biological specimens vitrified by plunge freezing

Authors Baeuerlein FJB, Renner M, El Chami D, Lehnart SE, Pastor-Pareja JC, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to voluminous biological specimens such
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14.05.2023

The role of structural vs cellular remodeling in arrhythmogenesis: personalized computer models of atrial fibrillation

Authors Pikunov AV, Syunyaev RA, Ali R, Prakosa A, Boyle PM, Steckmeister V, Kutschka I, Rytkin E, Voigt N, Trayanova N, Efimov IR Journal BioRxiv Citation bioRxiv 2023.05.13.540632. Abstract Atrial fibrillation (AF) is a progressive disease involving both structural and functional remodeling. To investigate the contribution of cell-scale functional remodeling
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11.04.2023

Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons

Authors Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J   Journal BioRxiv   Citation bioRxiv 2023.04.11.535831.   Abstract Pre- and postsynaptic forms of long-term potentiation (LTP) are candidate synaptic mechanisms underlying learning and memory. At layer
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12.03.2023

Impact of Phosphorylation on alpha-Synuclein Structural Determinants

Authors Dorn AE, de Bruyn E, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P   Journal BioRxiv   Citation bioRxiv 2023.03.10.531864.   Abstract Serine 129 and, to a lesser extent, serine 87 can appear phosphorylated in the intrinsically disordered protein human α-synuclein (AS), a key player in Parkinson’s
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28.02.2023

In vitro reconstitution of chromatin domains

Authors Quililan K, Oberbeckmann E, Cramer P, Oudelaar AM   Journal BioRxiv   Citation bioRxiv 2023.02.27.530214.   Abstract The spatial organization of the genome modulates nuclear processes, including transcription, replication, and DNA repair1,2. Eukaryotic genomes are organized into distinct 3D chromatin domains3. However, the molecular mechanisms that drive the formation
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23.12.2022

Dystrophin is a mechanical tension modulator

Authors Hofemeier AD, Muenker TM, Herkenrath F, Ristau M, Brandt M, Shahriyari M, Tiburcy M, Zimmermann WH, Lenz C, Mamchaoui K, Bigot A, Gilbert PM, Betz T Journal BioRxiv Citation bioRxiv 2022.12.23.521750. Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where increasing muscle weakness leads to
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