Biomedical Optics Express

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25.08.2022

Combined optical fluorescence microscopy and X-ray tomography reveals substructures in cell nuclei in 3D

Authors Wittmeier A, Bernhardt M, Robisch A-L, Cassini C, Osterhoff M, Salditt T, Köster S Journal Biomedical Optics Express Citation Biomed. Opt. Express 13, 4954-4969 (2022) Abstract The function of a biological cell is fundamentally defined by the structural architecture of packaged DNA in the nucleus. Elucidating information about the
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15.11.2021

Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography

Authors Eckermann M, van der Meer F, Cloetens P, Ruhwedel T, Möbius W, Stadelmann C, Salditt T Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 7582-7598 (2021). Abstract In this work, we optimize the setups and experimental parameters of X-ray phase-contrast computed-tomography for the three-dimensional imaging of the cyto-
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19.10.2021

Label-free imaging of age-related cardiac structural changes in non-human primates using multiphoton nonlinear microscopy

Authors Khan A, Ramos-Gomes F, Markus A, Mietsch M, Hinkel R, Alves F Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 7009-7023 (2021). Abstract Heart failure is one of the most common causes of morbidity and mortality. Both maturational abnormalities and age-associated cardiac pathologies contribute to heart failure. Imaging-based
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07.05.2021

Rapid multi-plane phase-contrast microscopy reveals torsional dynamics in flagellar motion

Authors Mojiri S, Isbaner S, Mühle S, Jang H, Bae AJ, Gregor I, Golami A, Enderlein J Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 3169-3180 (2021). Abstract High speed volumetric optical microscopy is an important tool for observing rapid processes in living cells or for real-time tracking of
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19.05.2020

Tomographic STED microscopy

Authors Krüger JR, Keller-Findeisen J, Geisler C, Egner A Journal Biomedical Optics Express Citation Biomed. Opt. Express 11, 3139-3163 (2020). Abstract Stimulated emission depletion (STED) microscopy is a versatile imaging method with diffraction-unlimited resolution. Here, we present a novel STED microscopy variant that achieves either increased resolution at equal laser
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23.03.2020

Elemental quantification and analysis of structural abnormalities in neurons from Parkinson’s-diseased brains by X-ray fluorescence microscopy and diffraction

Authors Joppe K, Nicolas JD, Grünewald TA, Eckermann M, Salditt T, Lingor P Journal Biomedical Optics Express Citation Biomed. Opt. Express. 2020 11(4). Abstract In this work we use scanning X-ray microscopy to study the structure and elemental composition of neuromelanin-positive neurons in substantia nigra tissue of Parkinson patients (PD) and controls.
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18.03.2020

Multi-Scale X-Ray Phase-Contrast Tomography Of Murine Heart Tissue

Authors Reichardt M, Frohn J, Khan A, Alves F, Salditt T Journal Biomedical Optics Express Citation Biomed Opt Express. 2020 May 1; 11(5): 2633–2651. Abstract The spatial organization of cardiac muscle tissue exhibits a complex structure on multiple length scales, from the sarcomeric unit to the whole organ. Here we
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