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28.08.2025

Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins

Authors Pikunov AV, Syunyaev RA, Ali R, Prakosa A, Gams A, Boyle PM, Steckmeister V, Kutschka I, Rytkin E, Voigt N, Trayanova N, Efimov IR Journal Circulation: Arrhythmia and Electrophysiology Citation Circ Arrhythm Electrophysiol. 2025 Aug 28:e013898. Abstract Background: Atrial fibrillation (AF) is a progressive disease involving both structural and
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25.08.2025

Blebbistatin reduces calcium buffering in cardiomyocytes: Consequences for cellular electrophysiology

Authors Sobitov I, Ritzenhoff K, Gaulrapp M, Becker L, Liutkute A, Seibertz F, Fakuade FE, Mason FE, Voigt N Journal The Journal of Physiology Citation J Physiol. 2025 Aug 25 Abstract Blebbistatin is an excitation-contraction uncoupling agent commonly used in cardiac optical mapping; however, it has been reported to influence
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22.08.2025

Seeing the heart in 3-D: Mapping arrhythmias across modalities

Authors Zgierski-Johnston CM, Huisken J Journal The Journal of Physiology Citation J Physiol. 2025 Aug 22 Abstract No abstract available. DOI 10.1113/JP289664   Pubmed Link  
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19.08.2025

Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses

Authors Voorn RA, Sternbach M, Bourien J, Komiyama N, Rankovic V, Wolf F, Grant SGN, Vogl C Journal BioRxiv Citation bioRxiv 2025.08.19.671016 Abstract Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that
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19.08.2025

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain

Authors Kumar NH, Kluever V, Kaufmann SV, Bergmann C, Mousaei K, Tomas M, Marrero MC, Chopra A, Hirose M, Pallas M, Sanfeliu C, Ibrahim SM, Fischer A, Outeiro TF, Urlaub H, Tchumatchenko T, Lopez Otin C, Fornasiero EF Journal BioRxiv Citation bioRxiv 2025.08.14.669896 Abstract Brain aging is a major risk
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18.08.2025

Introduction to photoswitches and photopharmacology

Authors Cacciarini M, Woolley GA, Szymanski W, Simeth NA Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2025 Aug 18. Abstract No abstract available. DOI 10.1039/d5ob90098k   Pubmed Link  
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18.08.2025

Super-Resolution Axial Imaging for Quantifying Piconewton Traction Forces in Live Cells

Authors Wang DX, Gallea JI, Kong DM, Enderlein J, Chen T Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2025 Aug 18:e202506864. Abstract Cell mechanics play a pivotal role in regulating numerous biological processes. Although super-resolution microscopy enables the imaging of cellular forces in the
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18.08.2025

Direct mechanical communication of cellular to nuclear shape in oocytes

Authors Vos BE, Vadapalli Y, Muenker TM, Astad Jentoft IM, Todisco E, Eskandari MA, Schuh M, Lenart P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Aug 18:S0006-3495(25)00524-7. Abstract The mechanical properties of the cytoplasm and nucleoplasm are crucial for the correct and robust functioning of a cell and
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11.08.2025

Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry

Authors Welp LM, Wulf A, Chernev A, Horokhovskyi Y, Moshkovskii S, Dybkov O, Neumann P, Pašen M, Siraj A, Raabe M, Göthert H, Walshe JL, Infante DA, de A P Schwarzer AC, Dickmanns A, Johannsson S, Schmitzová J, Wohlgemuth I, Netz E, He Y, Fritzemeier K, Delanghe B, Viner R,
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08.08.2025

Update on Gastric Pacemaking: Relevance for Gastroparesis

Authors Riebeling J, Patejdl R, Zipf D, Conradi LC, Ghadimi M, Gundling F, Bruegmann T. Journal Zentralblatt für Chirurgie Citation Zentralbl Chir. 2025 Aug;150(4):337-345. German. Abstract Gastroparesis is a disease in which gastric emptying is significantly decreased in the absence of a mechanical obstruction of the gastric outlet. In addition
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