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02.04.2025

Power-law adaptation in the presynaptic vesicle cycle

Authors Mikulasch FA, Georgiev SV, Rudelt L, Rizzoli SO, Priesemann V Journal Communications Biology Citation Commun Biol. 2025 Apr 2;8(1):542. Abstract After synaptic transmission, fused synaptic vesicles are recycled, enabling the synapse to recover its capacity for renewed release. The recovery steps, which range from endocytosis to vesicle docking and
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31.03.2025

Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light

Authors Zipf D, Vogt M, Sathyanarayanan U, Wagdi A, Riebeling J, Patejdl R, Bruegmann T Journal Neurogastroenterology and Motility Citation Neurogastroenterol Motil. 2025 Mar 31:e70028. Abstract Background: Optogenetics is a cutting-edge approach that can enable direct stimulation of gastric smooth muscle cells (SMC) by combining cell-specific overexpression of light-sensitive proteins
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31.03.2025

Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

Authors Solomon PAJ, Budde M, Kohshour MO, Adorjan K, Heilbronner M, Navarro-Flores A, Papiol S, Reich-Erkelenz D, Schulte EC, Senner F, Vogl T, Kaurani L, Krugger DM, Sananbenesi F, Pena T, Burkhardt S, Schutz AL, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter AJ, Figge C, Juckel
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27.03.2025

Understanding mitochondrial protein import: a revised model of the presequence translocase

Authors Jain N, Chacinska A, Rehling P Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2025 Mar 27:S0968-0004(25)00050-7. Abstract Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial
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26.03.2025

The inner nuclear layer in pediatric multiple sclerosis

Authors Hummel-Abmeier H, Naxer S, Kadas EM, Zimmermann H, Knaack B, Huppke P, Kowallick A, Meier K, Brandt AU, Paul F, Schittkowski M, Oertel FC, Gärtner J Journal Neurology: Neuroimmunology and Neuroinflammation Citation Neurol Neuroimmunol Neuroinflamm. 2025 May;12(3):e200387. Abstract Background and objectives: Pediatric onset multiple sclerosis (POMS) leads to optic
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26.03.2025

Microtubules as a versatile reference standard for expansion microscopy

Authors Chowdhury R, Mimoso T, Chouaib AA, Mougios N, Krah D, Opazo F, Köster S, Rizzoli SO, Shaib AH Journal Communications Biology Citation Commun Biol. 2025 Mar 26;8(1):499. Abstract Expansion microscopy (ExM) is continually improving, and new ExM variants need to be validated on well-defined biological structures. There is no
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25.03.2025

Tiling artifacts and trade-offs of feature normalization in the segmentation of large biological images

Authors Buglakova E, Archit A, D’Imprima E, Mahamid J, Pape C, Kreshuk A Journal Arxiv Citation arXiv:2503.19545. Abstract Segmentation of very large images is a common problem in microscopy, medical imaging or remote sensing. The problem is usually addressed by sliding window inference, which can theoretically lead to seamlessly stitched
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24.03.2025

XRCC4-related microcephalic primordial dwarfism: description of a clinical series of 7 cases, phenotype expansion and new diagnostic approaches

Authors Cuinat S, Chatron N, Petit F, Brunelle P, Dincuff E, Aubert Mucca M, Bieth E, Schmetz A, Rieder H, Wollnik B, Kaulfuß S, Yigit G, McKeown C, Savage T, Mulligan MR, Bicknell LS, Corsten-Janssen N, Edery P, Lesca G, de Villartay JP, Putoux A Journal European Journal of Human
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24.03.2025

PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exo- and endocytosis

Authors Georgiev SV, Rizzoli SO Journal Scientific Reports Citation Sci Rep 15, 10093 (2025). Abstract Neuronal communication relies on synaptic vesicle recycling, which has long been investigated by live imaging approaches. Synapto-pHluorins, genetically encoded reporters that incorporate a pH-sensitive variant of GFP within the lumen of the synaptic vesicle, have
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22.03.2025

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity

Authors Lin KH, Ranjan M, Lipstein N, Brose N, Neher E, Taschenberger H Journal The Journal of Physiology Citation J Physiol. 2025 Mar 22. Abstract Heterogeneity in synaptic strength and short-term plasticity (STP) was characterized in post-hearing rat calyx of Held synapses at near-physiological external [Ca2+] under control conditions and
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