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Study results open door to heart failure treatment with ‘heart patch’
29.01.2025

Study results open door to heart failure treatment with ‘heart patch’

Results from rhesus macaques provide solid ground for a first-in-human investigation of heart repair with stem cell-derived engineered heart muscle. The study is a milestone for the clinical application of the ‘heart patch’ as an innovative treatment option for patients with advanced heart failure at the University Medical Center Göttingen
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Restoring sensory and movement impairments. New Göttingen CRC investigates causes for better therapies
25.11.2024

Restoring sensory and movement impairments. New Göttingen CRC investigates causes for better therapies

German Research Foundation (DFG) approves new Collaborative Research Centre at the University Medical Center Göttingen (UMG) with more than twelve million euros.   The German Research Foundation (DFG) will fund a new Collaborative Research Centre (CRC) led by the University Medical Center Göttingen (UMG) from 1 April 2025. The new
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Ovulation filmed from start to finish for the first time
21.10.2024

Ovulation filmed from start to finish for the first time

Approximately 400 times in a woman’s life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh, Christopher Thomas, and Tabea Lilian Marx from the Max Planck Institute (MPI) for Multidisciplinary Sciences have now succeeded in
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Intra-molecular distances in biomolecules measured optically with Ångström precision
10.10.2024

Intra-molecular distances in biomolecules measured optically with Ångström precision

A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to 1 nanometer and with Ångström precision. The intra-molecular
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ONE microscopy: from molecule to 3D structure with conventional microscopy
09.10.2024

ONE microscopy: from molecule to 3D structure with conventional microscopy

Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or
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Defective ‘shock absorber’ in heart muscle cells contributes to the development of atrial fibrillation
10.09.2024

Defective ‘shock absorber’ in heart muscle cells contributes to the development of atrial fibrillation

Impaired calcium buffering in heart muscle cells promotes the progression and perpetuation of atrial fibrillation. This was discovered by researchers from the Heart Center of the University Medical Center Göttingen (UMG) and the German Centre for Cardiovascular Research (DZHK). The findings offer potential starting points for new therapies. The results
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Protein folding helpers in their natural environment
22.08.2024

Protein folding helpers in their natural environment

Scientists from Martinsried and Göttingen have analyzed protein folding helpers, so-called chaperonin complexes, in their natural environment using cryo-electron tomography.   Cryo-electron tomography, or cryo-ET for short, can be used to visualize and analyze cellular structures in their natural environment. Researchers at the Max Planck Institute of Biochemistry (MPIB) in
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Egg cell maintenance: Long-lived proteins may be essential
10.07.2024

Egg cell maintenance: Long-lived proteins may be essential

Female mammals – including humans – are born with all of their egg cells. Of a woman’s one to two million egg cells, about 400 mature before menopause and can be fertilized. Some egg cells therefore survive for several decades – and need to remain functional over this long time.
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Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence
22.03.2024

Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence

Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
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Heart & Brain – Understanding Together
13.03.2024

Heart & Brain – Understanding Together

New special exhibition at the Forum Wissen opens on 18 April 2024   How does a “patch” for the heart work? Can we hear with light? And how can insights from basic research be used to help diagnose and treat diseases? The “Heart & Brain – understanding together” exhibition examines
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Else Kröner Fresenius Center for Optogenetic Therapies approved
08.03.2024

Else Kröner Fresenius Center for Optogenetic Therapies approved

Else Kröner-Fresenius-Stiftung (EKFS) supports new research center for optogenetic therapies with 37.4 million euros over ten years at the University Medical Center Göttingen (UMG). The state of Lower Saxony is strongly supporting the establishment of the center and, together with the UMG, is holding out the prospect of up to
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Light into the darkness of photosynthesis: 3D insights into the copying machine of chloroplasts
01.03.2024

Light into the darkness of photosynthesis: 3D insights into the copying machine of chloroplasts

• A molecular 3D snapshot of the copying machine in chloroplasts, the RNA polymerase PEP, provides new insights into the evolution and function of plant photosynthesis. • Using a cryo-electron microscope, a high-resolution image of a 19-subunit PEP complex from white mustard (Sinapis alba) was taken. • Evolutionary analyses indicate
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New gene therapy for children born deaf in clinical trials
01.02.2024

New gene therapy for children born deaf in clinical trials

To date, hearing impairment can only be treated with medical devices such as hearing aids or cochlear implants. Gene therapy could offer an alternative in certain cases in the future. Building on pioneering work by researchers at the University Medical Center Göttingen (UMG), children suffering from a hearing impairment due
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Energy supply in human cells is subject to quality control
19.01.2024

Energy supply in human cells is subject to quality control

Researchers at the University Medical Center Göttingen (UMG) and members of the MBExC have discovered a new quality control mechanism that regulates the energy production in human cells. This process takes place in mitochondria, the power plants of the cell. Malfunctions of mitochondria lead to serious diseases of the nerves,
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New insights into sound coding in our ears
14.12.2023

New insights into sound coding in our ears

Sensory cells and neurons in the ear communicate by secreting neurotransmitter in response to sound stimuli. Scientists of the University Medical Center Göttingen, the Cluster of Excellence Multiscale Bioimaging, and the Max Planck Institute for Multidisciplinary Sciences describe new details of this process that regulates the release of neurotransmitters and
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Detecting side effects of new drugs on the heart more efficiently
05.12.2023

Detecting side effects of new drugs on the heart more efficiently

Scientists at the University Medical Center and the University of Göttingen have developed a new approach to keep intact heart tissue for about two weeks in culture for more efficient cardiotoxicity screening of new active substances and therapeutic approaches. The advantage: this method is already effective in a very early
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Protein stock for the beginning of a new life
06.11.2023

Protein stock for the beginning of a new life

How mysterious structures in the egg cell supply the early embryo as protein storage sites When mammals have offspring, they invest a lot. Unlike fish or frogs, the embryo cannot develop on its own. It has to implant in the uterus, where it is supplied with everything it needs to
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Heart and Brain Together in Focus – Public lecture series starting Nov. 7, 2023
13.10.2023

Heart and Brain Together in Focus – Public lecture series starting Nov. 7, 2023

„Herz und Hirn gemeinsam im Fokus“ (Heart and Brain Together in Focus) is the title of the public lecture series of the University of Göttingen and the Lower Saxony Academy of Sciences and Humanities in Göttingen in the winter semester 2023/2024. In the series, scientists of the Göttingen Cluster of
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