29.01.2025
Study results open door to heart failure treatment with ‘heart patch’
Results from rhesus macaques provide solid ground for a first-in-human investigation of heart repair with stem cell-derived engineered heart muscle. The study is a milestone for the clinical application of the ‘heart patch’ as an innovative treatment option for patients with advanced heart failure at the University Medical Center Göttingen
25.11.2024
Restoring sensory and movement impairments. New Göttingen CRC investigates causes for better therapies
German Research Foundation (DFG) approves new Collaborative Research Centre at the University Medical Center Göttingen (UMG) with more than twelve million euros. The German Research Foundation (DFG) will fund a new Collaborative Research Centre (CRC) led by the University Medical Center Göttingen (UMG) from 1 April 2025. The new
21.10.2024
Ovulation filmed from start to finish for the first time
Approximately 400 times in a woman’s life, a mature egg makes the “leap.” It is released into the fallopian tube, ready for fertilization by the sperm. Researchers led by Melina Schuh, Christopher Thomas, and Tabea Lilian Marx from the Max Planck Institute (MPI) for Multidisciplinary Sciences have now succeeded in
10.10.2024
Intra-molecular distances in biomolecules measured optically with Ångström precision
A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute (MPI) for Multidisciplinary Sciences in Göttingen and the MPI for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to 1 nanometer and with Ångström precision. The intra-molecular
09.10.2024
ONE microscopy: from molecule to 3D structure with conventional microscopy
Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy enables the detection of structural changes in damaged or
10.09.2024
Defective ‘shock absorber’ in heart muscle cells contributes to the development of atrial fibrillation
Impaired calcium buffering in heart muscle cells promotes the progression and perpetuation of atrial fibrillation. This was discovered by researchers from the Heart Center of the University Medical Center Göttingen (UMG) and the German Centre for Cardiovascular Research (DZHK). The findings offer potential starting points for new therapies. The results
22.08.2024
Protein folding helpers in their natural environment
Scientists from Martinsried and Göttingen have analyzed protein folding helpers, so-called chaperonin complexes, in their natural environment using cryo-electron tomography. Cryo-electron tomography, or cryo-ET for short, can be used to visualize and analyze cellular structures in their natural environment. Researchers at the Max Planck Institute of Biochemistry (MPIB) in
10.07.2024
Egg cell maintenance: Long-lived proteins may be essential
Female mammals – including humans – are born with all of their egg cells. Of a woman’s one to two million egg cells, about 400 mature before menopause and can be fertilized. Some egg cells therefore survive for several decades – and need to remain functional over this long time.
22.03.2024
Minister of Science Falko Mohrs visits Göttingen Cluster of Excellence
Falko Mohrs, Minister of Science and Culture of Lower Saxony, visited the researchers of the Göttingen Cluster of Excellence “Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells” (MBExC) on Friday, 22 March 2024. The occasion was the continuation application to be submitted by MBExC in August to apply
13.03.2024
Heart & Brain – Understanding Together
New special exhibition at the Forum Wissen opens on 18 April 2024 How does a “patch” for the heart work? Can we hear with light? And how can insights from basic research be used to help diagnose and treat diseases? The “Heart & Brain – understanding together” exhibition examines
08.03.2024
Else Kröner Fresenius Center for Optogenetic Therapies approved
Else Kröner-Fresenius-Stiftung (EKFS) supports new research center for optogenetic therapies with 37.4 million euros over ten years at the University Medical Center Göttingen (UMG). The state of Lower Saxony is strongly supporting the establishment of the center and, together with the UMG, is holding out the prospect of up to
01.03.2024
Light into the darkness of photosynthesis: 3D insights into the copying machine of chloroplasts
• A molecular 3D snapshot of the copying machine in chloroplasts, the RNA polymerase PEP, provides new insights into the evolution and function of plant photosynthesis. • Using a cryo-electron microscope, a high-resolution image of a 19-subunit PEP complex from white mustard (Sinapis alba) was taken. • Evolutionary analyses indicate
01.02.2024
New gene therapy for children born deaf in clinical trials
To date, hearing impairment can only be treated with medical devices such as hearing aids or cochlear implants. Gene therapy could offer an alternative in certain cases in the future. Building on pioneering work by researchers at the University Medical Center Göttingen (UMG), children suffering from a hearing impairment due
19.01.2024
Energy supply in human cells is subject to quality control
Researchers at the University Medical Center Göttingen (UMG) and members of the MBExC have discovered a new quality control mechanism that regulates the energy production in human cells. This process takes place in mitochondria, the power plants of the cell. Malfunctions of mitochondria lead to serious diseases of the nerves,
14.12.2023
New insights into sound coding in our ears
Sensory cells and neurons in the ear communicate by secreting neurotransmitter in response to sound stimuli. Scientists of the University Medical Center Göttingen, the Cluster of Excellence Multiscale Bioimaging, and the Max Planck Institute for Multidisciplinary Sciences describe new details of this process that regulates the release of neurotransmitters and
05.12.2023
Detecting side effects of new drugs on the heart more efficiently
Scientists at the University Medical Center and the University of Göttingen have developed a new approach to keep intact heart tissue for about two weeks in culture for more efficient cardiotoxicity screening of new active substances and therapeutic approaches. The advantage: this method is already effective in a very early
06.11.2023
Protein stock for the beginning of a new life
How mysterious structures in the egg cell supply the early embryo as protein storage sites When mammals have offspring, they invest a lot. Unlike fish or frogs, the embryo cannot develop on its own. It has to implant in the uterus, where it is supplied with everything it needs to
13.10.2023
Heart and Brain Together in Focus – Public lecture series starting Nov. 7, 2023
„Herz und Hirn gemeinsam im Fokus“ (Heart and Brain Together in Focus) is the title of the public lecture series of the University of Göttingen and the Lower Saxony Academy of Sciences and Humanities in Göttingen in the winter semester 2023/2024. In the series, scientists of the Göttingen Cluster of